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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: ZMYM1

Summary for ZMYM1

Gene informationGene symbol

ZMYM1

Ensembl ID

ENSG00000197056

Entrez ID

79830

Gene namezinc finger MYM-type containing 1
SynonymsFLJ23151|MYM
Gene typeprotein_coding
UniProtAcc

Q5SVZ6


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Dataset with differentially expressed gene: ZMYM1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postEndothelial cells-0.7369661.10e-02

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Expression of ZMYM1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to ZMYM1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZMYM1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
ZMYM1hsa-miR-524-5p95.7885NM_001289091
ZMYM1hsa-miR-520d-5p95.7885NM_001289091
ZMYM1hsa-miR-616-5p94.115NM_001289091
ZMYM1hsa-miR-371b-5p94.115NM_001289091
ZMYM1hsa-miR-373-5p94.115NM_001289091
ZMYM1hsa-miR-1213591.184NM_001289091
ZMYM1hsa-miR-651-3p89.8807NM_001289091
ZMYM1hsa-miR-4477b87.1849NM_001289091
ZMYM1hsa-miR-6882-5p85.7138NM_001289091
ZMYM1hsa-miR-4711-3p83.3333NM_001289091
ZMYM1hsa-miR-1255b-2-3p82.8327NM_001289091
ZMYM1hsa-miR-154-5p81.6753NM_001289091
ZMYM1hsa-miR-6766-5p81.4184NM_001289091
ZMYM1hsa-miR-6756-5p81.4184NM_001289091
ZMYM1hsa-miR-5579-5p81.0369NM_001289091
ZMYM1hsa-miR-6509-5p80.5368NM_001289091
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Motifs and transcription factors (TFs) regulating ZMYM1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
ZMYM1taipale_tf_pairs__GCM1_PITX1_GGATTANNNNNNNTGCGGG_CAP_reprGCM1; PITX1 (directAnnotation).
ZMYM1transfac_pro__M06816ZNF263 (inferredBy_Orthology).
ZMYM1swissregulon__hs__PAX5PAX5 (directAnnotation).
ZMYM1transfac_pro__M05731ZNF660 (directAnnotation).
ZMYM1transfac_pro__M06164ZNF157 (directAnnotation).
ZMYM1taipale_tf_pairs__ELK1_TBX21_RAGGTSRNNNNNNNNNNNNNNNNCGGAAGYN_CAPELK1; TBX21 (directAnnotation).
ZMYM1tfdimers__MD00482POU5F1; RUNX3 (directAnnotation).
ZMYM1transfac_pro__M05298OVOL3 (directAnnotation).
ZMYM1metacluster_122.4CDC5L; ZNF382 (directAnnotation).
ZMYM1tfdimers__MD00586FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND; PPARG (directAnnotation).
ZMYM1tfdimers__MD00077MYCN; SREBF1 (directAnnotation).
ZMYM1transfac_pro__M06129GLI4 (directAnnotation).
ZMYM1metacluster_34.2IKZF1; IKZF1; ZNF143; ZNF143; ZNF143; ZNF282; ZNF282; ZNF282; ZNF76 (directAnnotation).
ZMYM1metacluster_103.2ZNF136; ZNF680 (directAnnotation).
ZMYM1metacluster_160.15ATF5; ATF5 (directAnnotation).
ZMYM1tfdimers__MD00455ETS1; MZF1 (directAnnotation).
ZMYM1transfac_pro__M07062RREB1 (directAnnotation).
ZMYM1transfac_pro__M05914ZIM3 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."