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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZMPSTE24

Summary for ZMPSTE24

Gene information	Gene symbol	ZMPSTE24
	Ensembl ID	ENSG00000084073
	Entrez ID	10269
	Gene name	zinc metallopeptidase STE24
	Synonyms	FACE-1\|HGPS\|PRO1\|STE24\|Ste24p
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ZMPSTE24

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.00471	3.53e-08

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Expression of ZMPSTE24 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZMPSTE24

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZMPSTE24

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZMPSTE24	hsa-miR-5582-5p	98.9839	NM_005857
ZMPSTE24	hsa-miR-12122	98.5933	NM_005857
ZMPSTE24	hsa-miR-5680	96.5389	NM_005857
ZMPSTE24	hsa-miR-3658	95.0821	NM_005857
ZMPSTE24	hsa-miR-153-5p	93.9671	NM_005857
ZMPSTE24	hsa-miR-4668-5p	91.258	NM_005857
ZMPSTE24	hsa-miR-548d-3p	90.9158	NM_005857
ZMPSTE24	hsa-miR-548ac	90.9158	NM_005857
ZMPSTE24	hsa-miR-548bb-3p	90.9158	NM_005857
ZMPSTE24	hsa-miR-548z	90.9158	NM_005857
ZMPSTE24	hsa-miR-548h-3p	90.9158	NM_005857
ZMPSTE24	hsa-miR-577	90.0895	NM_005857
ZMPSTE24	hsa-miR-506-3p	89.9862	NM_005857
ZMPSTE24	hsa-miR-124-3p	89.9862	NM_005857
ZMPSTE24	hsa-miR-548x-3p	89.8591	NM_005857
ZMPSTE24	hsa-miR-548aj-3p	89.8591	NM_005857
ZMPSTE24	hsa-miR-4659b-3p	88.8636	NM_005857
ZMPSTE24	hsa-miR-4659a-3p	88.8636	NM_005857
ZMPSTE24	hsa-miR-495-3p	86.3493	NM_005857
ZMPSTE24	hsa-miR-5688	86.3493	NM_005857
ZMPSTE24	hsa-miR-548ah-3p	85.874	NM_005857
ZMPSTE24	hsa-miR-548ae-3p	85.874	NM_005857
ZMPSTE24	hsa-miR-548am-3p	85.874	NM_005857
ZMPSTE24	hsa-miR-548aq-3p	85.874	NM_005857
ZMPSTE24	hsa-miR-548j-3p	85.874	NM_005857
ZMPSTE24	hsa-miR-451b	85.2231	NM_005857
ZMPSTE24	hsa-miR-9500	84.6309	NM_005857
ZMPSTE24	hsa-miR-7844-5p	84.2294	NM_005857
ZMPSTE24	hsa-miR-335-5p	83.511	NM_005857
ZMPSTE24	hsa-miR-10395-3p	81.9593	NM_005857
ZMPSTE24	hsa-miR-18a-3p	81.1537	NM_005857
ZMPSTE24	hsa-miR-6505-5p	80.8384	NM_005857

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Motifs and transcription factors (TFs) regulating ZMPSTE24

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."