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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZKSCAN1

Summary for ZKSCAN1

Gene information	Gene symbol	ZKSCAN1
	Ensembl ID	ENSG00000106261
	Entrez ID	7586
	Gene name	zinc finger with KRAB and SCAN domains 1
	Synonyms	KOX18\|PHZ-37\|ZNF139\|ZNF36\|ZSCAN33
	Gene type	protein_coding
	UniProtAcc	P17029

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Dataset with differentially expressed gene: ZKSCAN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.388492	3.15e-28
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.36654	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.410053	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.321579	1.43e-19
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.334664	4.77e-15

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Expression of ZKSCAN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZKSCAN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
ZKSCAN1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating ZKSCAN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZKSCAN1	hsa-miR-302e	97.337	NM_001287054
ZKSCAN1	hsa-miR-6809-3p	95.538	NM_001287054
ZKSCAN1	hsa-miR-4659a-3p	95.0176	NM_001287054
ZKSCAN1	hsa-miR-4659b-3p	95.0176	NM_001287054
ZKSCAN1	hsa-miR-9-5p	94.1697	NM_001287054
ZKSCAN1	hsa-miR-6778-3p	93.1882	NM_001287055
ZKSCAN1	hsa-miR-302c-3p	92.0517	NM_001287054
ZKSCAN1	hsa-miR-302a-3p	92.0517	NM_001287054
ZKSCAN1	hsa-miR-302d-3p	92.0517	NM_001287054
ZKSCAN1	hsa-miR-302b-3p	92.0517	NM_001287054
ZKSCAN1	hsa-miR-146a-3p	91.7772	NM_001287054
ZKSCAN1	hsa-miR-520f-3p	90.9645	NM_001287054
ZKSCAN1	hsa-miR-12118	90.8623	NM_001287055
ZKSCAN1	hsa-miR-3173-3p	90.8623	NM_001287055
ZKSCAN1	hsa-miR-1250-3p	90.5981	NM_001287054
ZKSCAN1	hsa-miR-6891-5p	90.4307	NM_001287055
ZKSCAN1	hsa-miR-520a-3p	90.074	NM_001287054
ZKSCAN1	hsa-miR-520b-3p	90.074	NM_001287054
ZKSCAN1	hsa-miR-520e-3p	90.074	NM_001287054
ZKSCAN1	hsa-miR-373-3p	90.074	NM_001287054
ZKSCAN1	hsa-miR-372-3p	90.074	NM_001287054
ZKSCAN1	hsa-miR-520c-3p	90.074	NM_001287054
ZKSCAN1	hsa-miR-520d-3p	90.074	NM_001287054
ZKSCAN1	hsa-miR-1208	89.3223	NM_001287055
ZKSCAN1	hsa-miR-6853-3p	89.1162	NM_001287055
ZKSCAN1	hsa-miR-1266-5p	88.8668	NM_001287054
ZKSCAN1	hsa-miR-4518	88.8668	NM_001287054
ZKSCAN1	hsa-miR-4743-3p	88.1857	NM_001287054
ZKSCAN1	hsa-miR-5680	88.1082	NM_001287055
ZKSCAN1	hsa-miR-3059-5p	87.5297	NM_001287054
ZKSCAN1	hsa-miR-3163	87.4515	NM_001287055
ZKSCAN1	hsa-miR-4311	87.3447	NM_001287055
ZKSCAN1	hsa-miR-3164	87.2692	NM_001287055
ZKSCAN1	hsa-miR-6820-3p	87.2692	NM_001287055
ZKSCAN1	hsa-miR-670-3p	86.5699	NM_001287054
ZKSCAN1	hsa-miR-302f	85.8454	NM_001287055
ZKSCAN1	hsa-miR-4534	85.4756	NM_001287055
ZKSCAN1	hsa-miR-4687-5p	84.9852	NM_001287055
ZKSCAN1	hsa-miR-371a-5p	84.3959	NM_001287055
ZKSCAN1	hsa-miR-504-3p	83.8217	NM_001287055
ZKSCAN1	hsa-miR-218-1-3p	83.663	NM_001287055
ZKSCAN1	hsa-miR-196a-1-3p	83.0925	NM_001287054
ZKSCAN1	hsa-miR-4446-5p	81.7986	NM_001287055
ZKSCAN1	hsa-miR-548c-3p	81.4929	NM_001287054
ZKSCAN1	hsa-miR-208b-5p	81.0395	NM_001287054
ZKSCAN1	hsa-miR-208a-5p	81.0395	NM_001287054
ZKSCAN1	hsa-miR-4271	80.6687	NM_001287055
ZKSCAN1	hsa-miR-548p	80.613	NM_001287054

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Motifs and transcription factors (TFs) regulating ZKSCAN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZKSCAN1	transfac_pro__M06035	ZNF749 (directAnnotation).
ZKSCAN1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
ZKSCAN1	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
ZKSCAN1	metacluster_98.1	ZNF524 (directAnnotation).
ZKSCAN1	jaspar__MA1483.2	ELF2 (directAnnotation).
ZKSCAN1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ZKSCAN1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ZKSCAN1	cisbp__M08198	ELF1 (directAnnotation).
ZKSCAN1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
ZKSCAN1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
ZKSCAN1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ZKSCAN1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ZKSCAN1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
ZKSCAN1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
ZKSCAN1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
ZKSCAN1	jaspar__MA1708.1	ETV7 (directAnnotation).
ZKSCAN1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
ZKSCAN1	cisbp__M02645	ETS1 (directAnnotation).
ZKSCAN1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
ZKSCAN1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ZKSCAN1	hdpi__ETV4	ETV4 (directAnnotation).
ZKSCAN1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ZKSCAN1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
ZKSCAN1	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
ZKSCAN1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
ZKSCAN1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
ZKSCAN1	jaspar__MA0079.5	SP1 (directAnnotation).
ZKSCAN1	metacluster_134.3	FOXA1; FOXA1; FOXC1; FOXG1; FOXG1; FOXI1; FOXJ3; FOXJ3; FOXJ3; FOXK2; FOXL2; FOXO1; FOXO1; FOXO1; FOXO3; FOXO3; FOXO4; FOXO4; FOXO4; FOXP1; FOXP1; FOXP2; FOXP2; FOXP2 (directAnnotation). FOXD1; FOXJ2; FOXJ2; FOXJ3; FOXK1; FOXL2; FOXL2; FOXL2; FOXO1; FOXO3; FOXO3; FOXP2 (inferredBy_Orthology).
ZKSCAN1	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."