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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZIC3

Summary for ZIC3

Gene information	Gene symbol	ZIC3
	Ensembl ID	ENSG00000156925
	Entrez ID	7547
	Gene name	Zic family member 3
	Synonyms	HTX\|HTX1\|ZNF203
	Gene type	protein_coding
	UniProtAcc	O60481

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Dataset with differentially expressed gene: ZIC3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.397837	0.00e+00

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Expression of ZIC3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZIC3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZIC3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZIC3	hsa-miR-4262	98.8631	NM_003413
ZIC3	hsa-miR-181a-5p	98.7724	NM_003413
ZIC3	hsa-miR-181d-5p	98.7724	NM_003413
ZIC3	hsa-miR-181c-5p	98.7724	NM_003413
ZIC3	hsa-miR-181b-5p	98.7724	NM_003413
ZIC3	hsa-miR-155-5p	98.5039	NM_003413
ZIC3	hsa-miR-197-3p	98.0946	NM_003413
ZIC3	hsa-miR-4694-3p	97.9777	NM_003413
ZIC3	hsa-miR-3133	97.7733	NM_003413
ZIC3	hsa-miR-3658	96.7991	NM_003413
ZIC3	hsa-miR-587	96.4581	NM_003413
ZIC3	hsa-miR-4803	95.5985	NM_003413
ZIC3	hsa-miR-548an	95.0801	NM_003413
ZIC3	hsa-miR-3662	94.9372	NM_003413
ZIC3	hsa-miR-4297	94.3397	NM_003413
ZIC3	hsa-miR-6511a-5p	94.0612	NM_003413
ZIC3	hsa-miR-1910-3p	94.0612	NM_003413
ZIC3	hsa-miR-4324	94.024	NM_003413
ZIC3	hsa-miR-335-3p	93.9501	NM_003413
ZIC3	hsa-miR-133a-3p	93.8819	NM_003413
ZIC3	hsa-miR-133b	93.8819	NM_003413
ZIC3	hsa-miR-1200	93.6945	NM_003413
ZIC3	hsa-miR-302c-5p	93.6276	NM_003413
ZIC3	hsa-miR-3143	93.2499	NM_003413
ZIC3	hsa-miR-4700-3p	92.5589	NM_003413
ZIC3	hsa-miR-5581-5p	92.0459	NM_003413
ZIC3	hsa-miR-6513-3p	91.9314	NM_003413
ZIC3	hsa-miR-556-3p	91.7685	NM_003413
ZIC3	hsa-miR-4264	91.5836	NM_003413
ZIC3	hsa-miR-3613-3p	91.1004	NM_003413
ZIC3	hsa-miR-4699-5p	90.9376	NM_003413
ZIC3	hsa-miR-153-5p	90.6789	NM_003413
ZIC3	hsa-miR-12136	89.3327	NM_003413
ZIC3	hsa-miR-513b-5p	89.2635	NM_003413
ZIC3	hsa-miR-4420	88.9618	NM_003413
ZIC3	hsa-miR-181b-3p	88.9618	NM_003413
ZIC3	hsa-miR-181b-2-3p	88.9618	NM_003413
ZIC3	hsa-miR-4328	88.8603	NM_003413
ZIC3	hsa-miR-3924	88.8584	NM_003413
ZIC3	hsa-miR-524-5p	88.8032	NM_003413
ZIC3	hsa-miR-520d-5p	88.8032	NM_003413
ZIC3	hsa-miR-5002-3p	88.7389	NM_003413
ZIC3	hsa-miR-544b	88.7233	NM_003413
ZIC3	hsa-miR-374a-5p	87.8165	NM_003413
ZIC3	hsa-miR-4699-3p	87.795	NM_003413
ZIC3	hsa-miR-4725-3p	87.2072	NM_003413
ZIC3	hsa-miR-4271	87.2072	NM_003413
ZIC3	hsa-miR-6780b-5p	87.2072	NM_003413
ZIC3	hsa-miR-5000-3p	86.6245	NM_003413
ZIC3	hsa-miR-4436a	86.6245	NM_003413

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Motifs and transcription factors (TFs) regulating ZIC3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZIC3	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."