Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZHX3

Summary for ZHX3

Gene information	Gene symbol	ZHX3
	Ensembl ID	ENSG00000174306
	Entrez ID	23051
	Gene name	zinc fingers and homeoboxes 3
	Synonyms	KIAA0395\|TIX1
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: ZHX3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.341952	1.61e-24

Top

Expression of ZHX3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ZHX3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ZHX3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZHX3	hsa-miR-5011-5p	98.0573	NM_015035
ZHX3	hsa-miR-12113	96.6523	NM_015035
ZHX3	hsa-miR-29c-3p	95.3297	NM_015035
ZHX3	hsa-miR-29b-3p	95.3297	NM_015035
ZHX3	hsa-miR-29a-3p	95.3297	NM_015035
ZHX3	hsa-miR-4539	95.1868	NM_015035
ZHX3	hsa-miR-4311	92.5145	NM_015035
ZHX3	hsa-miR-190a-3p	91.1268	NM_015035
ZHX3	hsa-miR-4764-5p	90.9663	NM_015035
ZHX3	hsa-miR-153-5p	90.8501	NM_015035
ZHX3	hsa-miR-760	90.1369	NM_015035
ZHX3	hsa-miR-29b-2-5p	89.0825	NM_015035
ZHX3	hsa-miR-5008-5p	88.3674	NM_015035
ZHX3	hsa-miR-205-5p	88.023	NM_015035
ZHX3	hsa-miR-548e-5p	87.343	NM_015035
ZHX3	hsa-miR-7150	87.218	NM_015035
ZHX3	hsa-miR-3202	87.0496	NM_015035
ZHX3	hsa-miR-146a-3p	86.6378	NM_015035
ZHX3	hsa-miR-6867-5p	86.1799	NM_015035
ZHX3	hsa-miR-3127-5p	86.048	NM_015035
ZHX3	hsa-miR-302c-5p	85.7479	NM_015035
ZHX3	hsa-miR-6769b-5p	84.8967	NM_015035
ZHX3	hsa-miR-5682	84.521	NM_015035
ZHX3	hsa-miR-4736	84.3347	NM_015035
ZHX3	hsa-miR-3919	84.1818	NM_015035
ZHX3	hsa-miR-2110	83.9159	NM_015035
ZHX3	hsa-miR-4533	83.3621	NM_015035
ZHX3	hsa-miR-1207-5p	83.0533	NM_015035
ZHX3	hsa-miR-7106-5p	82.6416	NM_015035
ZHX3	hsa-miR-6810-5p	82.3288	NM_015035
ZHX3	hsa-miR-3065-3p	82.19	NM_015035
ZHX3	hsa-miR-3157-5p	81.9179	NM_015035
ZHX3	hsa-miR-196a-1-3p	80.6464	NM_015035
ZHX3	hsa-miR-1303	80.5923	NM_015035
ZHX3	hsa-miR-6871-3p	80.1143	NM_015035

Page: 1

Top

Motifs and transcription factors (TFs) regulating ZHX3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."