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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZHX1

Summary for ZHX1

Gene information	Gene symbol	ZHX1
	Ensembl ID	ENSG00000165156
	Entrez ID	11244
	Gene name	zinc fingers and homeoboxes 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9UKY1

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Dataset with differentially expressed gene: ZHX1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.305377	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.276747	9.85e-07

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Expression of ZHX1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZHX1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZHX1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZHX1	hsa-miR-12136	99.6994	NM_001017926
ZHX1	hsa-miR-4282	99.3882	NM_001017926
ZHX1	hsa-miR-5587-5p	97.7475	NM_001017926
ZHX1	hsa-miR-4650-5p	96.2985	NM_001017926
ZHX1	hsa-miR-181b-2-3p	95.683	NM_001017926
ZHX1	hsa-miR-181b-3p	95.683	NM_001017926
ZHX1	hsa-miR-4420	95.683	NM_001017926
ZHX1	hsa-miR-27a-3p	95.6007	NM_001017926
ZHX1	hsa-miR-9985	95.6007	NM_001017926
ZHX1	hsa-miR-27b-3p	95.6007	NM_001017926
ZHX1	hsa-miR-4671-3p	95.5765	NM_001017926
ZHX1	hsa-miR-103a-3p	94.1832	NM_001017926
ZHX1	hsa-miR-107	94.1832	NM_001017926
ZHX1	hsa-miR-561-3p	94.0912	NM_001017926
ZHX1	hsa-miR-96-5p	93.8901	NM_001017926
ZHX1	hsa-miR-12133	93.8703	NM_001017926
ZHX1	hsa-miR-1271-5p	93.7134	NM_001017926
ZHX1	hsa-miR-199a-3p	93.6093	NM_001017926
ZHX1	hsa-miR-199b-3p	93.6093	NM_001017926
ZHX1	hsa-miR-3129-5p	93.1073	NM_001017926
ZHX1	hsa-miR-335-3p	92.9657	NM_001017926
ZHX1	hsa-miR-513a-5p	92.9069	NM_001017926
ZHX1	hsa-miR-641	92.1911	NM_001017926
ZHX1	hsa-miR-3617-5p	92.1911	NM_001017926
ZHX1	hsa-miR-5197-3p	92.1731	NM_001017926
ZHX1	hsa-miR-9-3p	92.0474	NM_001017926
ZHX1	hsa-miR-3163	90.761	NM_001017926
ZHX1	hsa-miR-607	90.7163	NM_001017926
ZHX1	hsa-miR-203b-5p	90.5994	NM_001017926
ZHX1	hsa-miR-4528	90.4892	NM_001017926
ZHX1	hsa-miR-5699-5p	89.3579	NM_001017926
ZHX1	hsa-miR-2681-5p	89.327	NM_001017926
ZHX1	hsa-miR-4740-5p	88.8973	NM_001017926
ZHX1	hsa-miR-6718-5p	88.4376	NM_001017926
ZHX1	hsa-miR-335-5p	87.5485	NM_001017926
ZHX1	hsa-miR-5690	86.0558	NM_001017926
ZHX1	hsa-miR-212-3p	85.8858	NM_001017926
ZHX1	hsa-miR-132-3p	85.8858	NM_001017926
ZHX1	hsa-miR-4797-5p	85.6111	NM_001017926
ZHX1	hsa-miR-10395-3p	85.4205	NM_001017926
ZHX1	hsa-miR-27b-5p	84.8624	NM_001017926
ZHX1	hsa-miR-6868-3p	84.7779	NM_001017926
ZHX1	hsa-miR-8055	84.6474	NM_001017926
ZHX1	hsa-miR-103a-2-5p	83.3952	NM_001017926
ZHX1	hsa-miR-103a-1-5p	83.3952	NM_001017926
ZHX1	hsa-miR-182-5p	83.0009	NM_001017926
ZHX1	hsa-miR-16-1-3p	82.7507	NM_001017926
ZHX1	hsa-miR-3065-3p	82.7188	NM_001017926
ZHX1	hsa-miR-576-5p	82.4485	NM_001017926
ZHX1	hsa-miR-3919	82.1398	NM_001017926

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Motifs and transcription factors (TFs) regulating ZHX1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZHX1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ZHX1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ZHX1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
ZHX1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ZHX1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ZHX1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ZHX1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ZHX1	transfac_pro__M00652	NRF1 (directAnnotation).
ZHX1	hdpi__ETV4	ETV4 (directAnnotation).
ZHX1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ZHX1	transfac_pro__M04866	HDAC2 (directAnnotation).
ZHX1	jaspar__MA1122.1	TFDP1 (directAnnotation).
ZHX1	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
ZHX1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ZHX1	metacluster_135.11	NR2C2 (directAnnotation).
ZHX1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZHX1	tfdimers__MD00038	TFAP2C (directAnnotation).
ZHX1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ZHX1	metacluster_7.13	ZFX (directAnnotation).
ZHX1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZHX1	cisbp__M00968	MTF2 (directAnnotation).
ZHX1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZHX1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ZHX1	cisbp__M00341	PAX6 (directAnnotation).
ZHX1	metacluster_198.3	ZFP64 (directAnnotation).
ZHX1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZHX1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZHX1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ZHX1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZHX1	cisbp__M00788	ZFY (inferredBy_Orthology).
ZHX1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ZHX1	metacluster_175.1	ZNF283 (directAnnotation).
ZHX1	hdpi__ZNF304	ZNF304 (directAnnotation).
ZHX1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ZHX1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ZHX1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ZHX1	transfac_pro__M01199	TRIM28 (directAnnotation).
ZHX1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ZHX1	metacluster_151.2	ZNF23 (directAnnotation).
ZHX1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZHX1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZHX1	transfac_pro__M03806	ZBTB7C (directAnnotation).
ZHX1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."