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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZFAND1

Summary for ZFAND1

Gene information	Gene symbol	ZFAND1
	Ensembl ID	ENSG00000104231
	Entrez ID	79752
	Gene name	zinc finger AN1-type containing 1
	Synonyms	FLJ14007
	Gene type	protein_coding
	UniProtAcc	Q8TCF1

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Dataset with differentially expressed gene: ZFAND1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.355086	1.72e-31
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.321592	1.40e-45
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.456143	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.386494	0.00e+00

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Expression of ZFAND1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZFAND1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZFAND1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZFAND1	hsa-miR-6888-3p	96.9275	NM_024699
ZFAND1	hsa-miR-367-3p	94.5649	NM_024699
ZFAND1	hsa-miR-25-3p	94.5649	NM_024699
ZFAND1	hsa-miR-363-3p	94.5649	NM_024699
ZFAND1	hsa-miR-6834-3p	94.3589	NM_024699
ZFAND1	hsa-miR-6751-5p	93.8901	NM_024699
ZFAND1	hsa-miR-32-5p	93.8839	NM_024699
ZFAND1	hsa-miR-92b-3p	93.8839	NM_024699
ZFAND1	hsa-miR-92a-3p	93.8839	NM_024699
ZFAND1	hsa-miR-6516-3p	93.5727	NM_024699
ZFAND1	hsa-miR-6803-5p	92.8904	NM_024699
ZFAND1	hsa-miR-548l	92.6448	NM_024699
ZFAND1	hsa-miR-942-5p	92.2589	NM_024699
ZFAND1	hsa-miR-618	89.5927	NM_024699
ZFAND1	hsa-miR-3121-3p	88.5333	NM_024699
ZFAND1	hsa-miR-891b	88.1375	NM_024699
ZFAND1	hsa-miR-374a-3p	88.01	NM_024699
ZFAND1	hsa-miR-4732-3p	87.9236	NM_024699
ZFAND1	hsa-miR-6783-5p	87.1784	NM_024699
ZFAND1	hsa-miR-149-5p	85.9103	NM_024699
ZFAND1	hsa-miR-4703-5p	85.6611	NM_024699
ZFAND1	hsa-miR-4766-3p	85.3589	NM_024699
ZFAND1	hsa-miR-5009-5p	84.5393	NM_024699
ZFAND1	hsa-miR-8058	84.5393	NM_024699
ZFAND1	hsa-miR-2115-3p	83.436	NM_001170796
ZFAND1	hsa-miR-30e-5p	82.1366	NM_024699
ZFAND1	hsa-miR-30c-5p	82.1366	NM_024699
ZFAND1	hsa-miR-30b-5p	82.1366	NM_024699
ZFAND1	hsa-miR-30a-5p	82.1366	NM_024699
ZFAND1	hsa-miR-30d-5p	82.1366	NM_024699
ZFAND1	hsa-miR-570-3p	80.9955	NM_024699
ZFAND1	hsa-miR-4501	80.9433	NM_024699
ZFAND1	hsa-miR-3942-5p	80.9197	NM_024699
ZFAND1	hsa-miR-19b-1-5p	80.3026	NM_024699
ZFAND1	hsa-miR-19b-2-5p	80.3026	NM_024699
ZFAND1	hsa-miR-19a-5p	80.3026	NM_024699

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Motifs and transcription factors (TFs) regulating ZFAND1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZFAND1	metacluster_7.13	ZFX (directAnnotation).
ZFAND1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZFAND1	metacluster_161.4	LHX9 (directAnnotation).
ZFAND1	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
ZFAND1	metacluster_161.3	LHX9 (directAnnotation).
ZFAND1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ZFAND1	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
ZFAND1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ZFAND1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ZFAND1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ZFAND1	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."