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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZDHHC5

Summary for ZDHHC5

Gene information	Gene symbol	ZDHHC5
	Ensembl ID	ENSG00000156599
	Entrez ID	25921
	Gene name	zinc finger DHHC-type palmitoyltransferase 5
	Synonyms	DHHC5\|KIAA1748\|ZNF375
	Gene type	protein_coding
	UniProtAcc	Q9C0B5

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Dataset with differentially expressed gene: ZDHHC5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.295747	3.88e-29

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Expression of ZDHHC5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZDHHC5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZDHHC5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZDHHC5	hsa-miR-5011-5p	99.9988	NM_015457
ZDHHC5	hsa-miR-190a-3p	99.6381	NM_015457
ZDHHC5	hsa-miR-3145-3p	95.8909	NM_015457
ZDHHC5	hsa-miR-29b-1-5p	94.0886	NM_015457
ZDHHC5	hsa-miR-5196-3p	94.0065	NM_015457
ZDHHC5	hsa-miR-92a-3p	93.7338	NM_015457
ZDHHC5	hsa-miR-1290	92.2933	NM_015457
ZDHHC5	hsa-miR-1277-5p	91.8761	NM_015457
ZDHHC5	hsa-miR-367-3p	91.591	NM_015457
ZDHHC5	hsa-miR-92b-3p	91.591	NM_015457
ZDHHC5	hsa-miR-32-5p	91.591	NM_015457
ZDHHC5	hsa-miR-363-3p	91.591	NM_015457
ZDHHC5	hsa-miR-25-3p	91.591	NM_015457
ZDHHC5	hsa-miR-5692c	91.5746	NM_015457
ZDHHC5	hsa-miR-5692b	91.5746	NM_015457
ZDHHC5	hsa-miR-7113-5p	90.3842	NM_015457
ZDHHC5	hsa-miR-299-5p	89.884	NM_015457
ZDHHC5	hsa-miR-4747-5p	89.4112	NM_015457
ZDHHC5	hsa-miR-5196-5p	89.4112	NM_015457
ZDHHC5	hsa-miR-6840-3p	87.4992	NM_015457
ZDHHC5	hsa-miR-7152-3p	86.6345	NM_015457
ZDHHC5	hsa-miR-1226-3p	85.7475	NM_015457
ZDHHC5	hsa-miR-3074-5p	85.2765	NM_015457
ZDHHC5	hsa-miR-137-3p	84.9522	NM_015457
ZDHHC5	hsa-miR-374a-5p	84.907	NM_015457
ZDHHC5	hsa-miR-6825-5p	84.8024	NM_015457
ZDHHC5	hsa-miR-6893-3p	84.1034	NM_015457
ZDHHC5	hsa-miR-370-3p	84.1034	NM_015457
ZDHHC5	hsa-miR-374b-5p	82.9825	NM_015457
ZDHHC5	hsa-miR-3148	82.3108	NM_015457

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Motifs and transcription factors (TFs) regulating ZDHHC5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZDHHC5	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZDHHC5	cisbp__M00968	MTF2 (directAnnotation).
ZDHHC5	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ZDHHC5	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZDHHC5	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZDHHC5	cisbp__M00788	ZFY (inferredBy_Orthology).
ZDHHC5	hdpi__ZNF304	ZNF304 (directAnnotation).
ZDHHC5	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ZDHHC5	transfac_pro__M01199	TRIM28 (directAnnotation).
ZDHHC5	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZDHHC5	transfac_pro__M03806	ZBTB7C (directAnnotation).
ZDHHC5	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."