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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZDHHC3

Summary for ZDHHC3

Gene information	Gene symbol	ZDHHC3
	Ensembl ID	ENSG00000163812
	Entrez ID	51304
	Gene name	zinc finger DHHC-type palmitoyltransferase 3
	Synonyms	DHHC3\|GODZ\|ZNF373
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ZDHHC3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.615194	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.277424	0.00e+00

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Expression of ZDHHC3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZDHHC3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZDHHC3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZDHHC3	hsa-miR-6867-5p	97.4946	NM_016598
ZDHHC3	hsa-miR-3179	96.2545	NM_016598
ZDHHC3	hsa-miR-3148	94.6688	NM_016598
ZDHHC3	hsa-miR-4731-5p	94.1642	NM_016598
ZDHHC3	hsa-miR-4524a-3p	93.7981	NM_016598
ZDHHC3	hsa-miR-561-3p	92.9251	NM_016598
ZDHHC3	hsa-miR-4262	92.3676	NM_016598
ZDHHC3	hsa-miR-3190-3p	92.0847	NM_016598
ZDHHC3	hsa-miR-3910	91.7857	NM_016598
ZDHHC3	hsa-miR-4441	91.7705	NM_016598
ZDHHC3	hsa-miR-6721-5p	91.2056	NM_016598
ZDHHC3	hsa-miR-4649-3p	90.7731	NM_016598
ZDHHC3	hsa-miR-124-3p	89.8884	NM_016598
ZDHHC3	hsa-miR-506-3p	89.8884	NM_016598
ZDHHC3	hsa-miR-3147	89.7428	NM_016598
ZDHHC3	hsa-miR-185-3p	89.4351	NM_016598
ZDHHC3	hsa-miR-543	89.1082	NM_016598
ZDHHC3	hsa-miR-568	89.0462	NM_016598
ZDHHC3	hsa-miR-4726-3p	88.9087	NM_016598
ZDHHC3	hsa-miR-4291	88.9036	NM_016598
ZDHHC3	hsa-miR-508-3p	88.0201	NM_016598
ZDHHC3	hsa-miR-3662	87.2829	NM_016598
ZDHHC3	hsa-miR-4270	86.8353	NM_016598
ZDHHC3	hsa-miR-4481	86.7707	NM_016598
ZDHHC3	hsa-miR-1972	86.2973	NM_016598
ZDHHC3	hsa-miR-6770-5p	86.2462	NM_016598
ZDHHC3	hsa-miR-3714	85.8188	NM_016598
ZDHHC3	hsa-miR-5589-5p	85.5562	NM_016598
ZDHHC3	hsa-miR-371a-5p	85.472	NM_016598
ZDHHC3	hsa-miR-6833-3p	85.3198	NM_016598
ZDHHC3	hsa-miR-181a-5p	85.2896	NM_016598
ZDHHC3	hsa-miR-181b-5p	85.2896	NM_016598
ZDHHC3	hsa-miR-181c-5p	85.2896	NM_016598
ZDHHC3	hsa-miR-181d-5p	85.2896	NM_016598
ZDHHC3	hsa-miR-4725-3p	85.2769	NM_016598
ZDHHC3	hsa-miR-6780b-5p	85.2769	NM_016598
ZDHHC3	hsa-miR-6825-5p	85.2603	NM_016598
ZDHHC3	hsa-miR-3125	85.1291	NM_016598
ZDHHC3	hsa-miR-6828-5p	85.1034	NM_016598
ZDHHC3	hsa-miR-3916	85.0093	NM_016598
ZDHHC3	hsa-miR-6859-5p	84.9905	NM_016598
ZDHHC3	hsa-miR-589-3p	84.9248	NM_016598
ZDHHC3	hsa-miR-6799-3p	84.6631	NM_016598
ZDHHC3	hsa-miR-3173-5p	84.6631	NM_016598
ZDHHC3	hsa-miR-4640-5p	83.9931	NM_016598
ZDHHC3	hsa-miR-8075	83.7853	NM_016598
ZDHHC3	hsa-miR-6747-5p	83.7415	NM_016598
ZDHHC3	hsa-miR-6809-3p	83.6061	NM_016598
ZDHHC3	hsa-miR-4758-5p	83.5573	NM_016598
ZDHHC3	hsa-miR-320b	83.4604	NM_016598

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Motifs and transcription factors (TFs) regulating ZDHHC3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZDHHC3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."