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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZDHHC20

Summary for ZDHHC20

Gene information	Gene symbol	ZDHHC20
	Ensembl ID	ENSG00000180776
	Entrez ID	253832
	Gene name	zinc finger DHHC-type palmitoyltransferase 20
	Synonyms	DHHC20\|FLJ25952
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ZDHHC20

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.354472	0.00e+00

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Expression of ZDHHC20 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZDHHC20

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZDHHC20

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZDHHC20	hsa-miR-5187-3p	97.2838	NM_001286638
ZDHHC20	hsa-miR-1297	96.2732	NM_001286638
ZDHHC20	hsa-miR-3182	95.9553	NM_001286638
ZDHHC20	hsa-miR-561-3p	95.3296	NM_001286638
ZDHHC20	hsa-miR-4282	93.9044	NM_001286638
ZDHHC20	hsa-miR-5011-5p	93.8231	NM_001286638
ZDHHC20	hsa-miR-4795-3p	92.469	NM_001286638
ZDHHC20	hsa-miR-548l	91.9239	NM_001286638
ZDHHC20	hsa-miR-26b-5p	91.1873	NM_001286638
ZDHHC20	hsa-miR-26a-5p	91.1873	NM_001286638
ZDHHC20	hsa-miR-4760-5p	90.8587	NM_001286638
ZDHHC20	hsa-let-7a-3p	90.2582	NM_001286638
ZDHHC20	hsa-let-7f-1-3p	90.2582	NM_001286638
ZDHHC20	hsa-miR-98-3p	90.2582	NM_001286638
ZDHHC20	hsa-let-7b-3p	90.2582	NM_001286638
ZDHHC20	hsa-miR-12136	90.0911	NM_001286638
ZDHHC20	hsa-miR-4477a	89.9904	NM_001286638
ZDHHC20	hsa-miR-8061	89.713	NM_001286638
ZDHHC20	hsa-miR-494-3p	89.4891	NM_001286638
ZDHHC20	hsa-miR-3163	88.8956	NM_001286638
ZDHHC20	hsa-miR-5580-3p	88.5996	NM_001286638
ZDHHC20	hsa-miR-4465	86.71	NM_001286638
ZDHHC20	hsa-miR-190a-3p	86.5953	NM_001286638
ZDHHC20	hsa-miR-1250-3p	84.9327	NM_001286638
ZDHHC20	hsa-miR-3065-5p	84.0501	NM_001286638
ZDHHC20	hsa-miR-155-5p	83.6837	NM_001286638
ZDHHC20	hsa-miR-6867-5p	83.5545	NM_001286638
ZDHHC20	hsa-miR-101-3p	83.5213	NM_001286638
ZDHHC20	hsa-miR-653-5p	83.4201	NM_001286638
ZDHHC20	hsa-miR-659-3p	82.6281	NM_001286638
ZDHHC20	hsa-miR-5680	82.4051	NM_001286638
ZDHHC20	hsa-miR-153-5p	82.2937	NM_001286638
ZDHHC20	hsa-miR-548aw	81.9937	NM_001286638
ZDHHC20	hsa-miR-500a-5p	81.6954	NM_001286638
ZDHHC20	hsa-miR-126-5p	81.5906	NM_001286638
ZDHHC20	hsa-miR-4307	80.8558	NM_001286638
ZDHHC20	hsa-miR-7114-5p	80.3484	NM_001286638
ZDHHC20	hsa-miR-582-5p	80.2018	NM_001286638
ZDHHC20	hsa-miR-409-3p	80.181	NM_001286638
ZDHHC20	hsa-miR-190b-3p	80.0197	NM_001286638

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Motifs and transcription factors (TFs) regulating ZDHHC20

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZDHHC20	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ZDHHC20	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ZDHHC20	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ZDHHC20	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ZDHHC20	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ZDHHC20	jaspar__MA1721.1	ZNF93 (directAnnotation).
ZDHHC20	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZDHHC20	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ZDHHC20	transfac_pro__M01199	TRIM28 (directAnnotation).
ZDHHC20	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ZDHHC20	transfac_pro__M01253	CNOT3 (directAnnotation).
ZDHHC20	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ZDHHC20	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ZDHHC20	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ZDHHC20	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ZDHHC20	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ZDHHC20	cisbp__M00968	MTF2 (directAnnotation).
ZDHHC20	metacluster_7.13	ZFX (directAnnotation).
ZDHHC20	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ZDHHC20	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ZDHHC20	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ZDHHC20	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ZDHHC20	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ZDHHC20	transfac_pro__M00938	E2F1 (directAnnotation).
ZDHHC20	transfac_pro__M04893	TAF1 (directAnnotation).
ZDHHC20	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZDHHC20	transfac_pro__M04817	ZBTB33 (directAnnotation).
ZDHHC20	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ZDHHC20	metacluster_175.1	ZNF283 (directAnnotation).
ZDHHC20	cisbp__M00788	ZFY (inferredBy_Orthology).
ZDHHC20	tfdimers__MD00364	WT1 (directAnnotation).
ZDHHC20	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ZDHHC20	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
ZDHHC20	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ZDHHC20	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
ZDHHC20	transfac_pro__M01973	PLAG1 (directAnnotation).
ZDHHC20	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ZDHHC20	metacluster_198.3	ZFP64 (directAnnotation).
ZDHHC20	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ZDHHC20	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZDHHC20	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
ZDHHC20	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ZDHHC20	metacluster_144.13	HIC1; HIC1 (directAnnotation).
ZDHHC20	transfac_pro__M00665	SP3 (directAnnotation).
ZDHHC20	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZDHHC20	transfac_pro__M02898	SMAD3 (directAnnotation).
ZDHHC20	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
ZDHHC20	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
ZDHHC20	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
ZDHHC20	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."