Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZCCHC2

Summary for ZCCHC2

Gene information	Gene symbol	ZCCHC2
	Ensembl ID	ENSG00000141664
	Entrez ID	54877
	Gene name	zinc finger CCHC-type containing 2
	Synonyms	C18orf49\|FLJ20222\|FLJ20281\|KIAA1744
	Gene type	protein_coding
	UniProtAcc	Q9C0B9

Top

Dataset with differentially expressed gene: ZCCHC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.431683	8.15e-26
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.251728	3.26e-33

Top

Expression of ZCCHC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ZCCHC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ZCCHC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZCCHC2	hsa-miR-3671	99.3326	NM_017742
ZCCHC2	hsa-miR-4520-2-3p	99.1372	NM_017742
ZCCHC2	hsa-miR-335-3p	98.3523	NM_017742
ZCCHC2	hsa-miR-217-5p	98.3081	NM_017742
ZCCHC2	hsa-miR-4438	97.9604	NM_017742
ZCCHC2	hsa-miR-6807-3p	97.9555	NM_017742
ZCCHC2	hsa-miR-6749-3p	96.9745	NM_017742
ZCCHC2	hsa-miR-6828-5p	95.6155	NM_017742
ZCCHC2	hsa-miR-26b-3p	95.5976	NM_017742
ZCCHC2	hsa-miR-144-3p	95.5363	NM_017742
ZCCHC2	hsa-miR-6790-5p	95.4312	NM_017742
ZCCHC2	hsa-miR-4658	95.4312	NM_017742
ZCCHC2	hsa-miR-101-3p	95.2281	NM_017742
ZCCHC2	hsa-miR-603	95.0177	NM_017742
ZCCHC2	hsa-miR-30a-5p	94.9363	NM_017742
ZCCHC2	hsa-miR-30d-5p	94.9363	NM_017742
ZCCHC2	hsa-miR-30e-5p	94.9363	NM_017742
ZCCHC2	hsa-miR-30b-5p	94.9363	NM_017742
ZCCHC2	hsa-miR-30c-5p	94.9363	NM_017742
ZCCHC2	hsa-miR-7850-5p	94.4696	NM_017742
ZCCHC2	hsa-miR-6830-5p	93.9366	NM_017742
ZCCHC2	hsa-miR-3163	93.5934	NM_017742
ZCCHC2	hsa-miR-107	93.5301	NM_017742
ZCCHC2	hsa-miR-103a-3p	93.5301	NM_017742
ZCCHC2	hsa-miR-5579-5p	93.4661	NM_017742
ZCCHC2	hsa-miR-4668-3p	92.5048	NM_017742
ZCCHC2	hsa-miR-154-3p	92.2493	NM_017742
ZCCHC2	hsa-miR-487a-3p	92.2493	NM_017742
ZCCHC2	hsa-miR-6508-5p	92.1119	NM_017742
ZCCHC2	hsa-miR-607	92.0867	NM_017742
ZCCHC2	hsa-miR-4712-5p	92.0231	NM_017742
ZCCHC2	hsa-miR-770-5p	92.0231	NM_017742
ZCCHC2	hsa-miR-4428	91.902	NM_017742
ZCCHC2	hsa-miR-561-5p	91.5773	NM_017742
ZCCHC2	hsa-miR-23c	90.3191	NM_017742
ZCCHC2	hsa-miR-23b-3p	90.3191	NM_017742
ZCCHC2	hsa-miR-23a-3p	90.3191	NM_017742
ZCCHC2	hsa-miR-3973	89.9694	NM_017742
ZCCHC2	hsa-miR-8067	89.7059	NM_017742
ZCCHC2	hsa-miR-150-3p	89.4201	NM_017742
ZCCHC2	hsa-miR-9-3p	89.0794	NM_017742
ZCCHC2	hsa-miR-7160-5p	88.7997	NM_017742
ZCCHC2	hsa-miR-4799-5p	88.7756	NM_017742
ZCCHC2	hsa-miR-137-3p	88.3644	NM_017742
ZCCHC2	hsa-miR-153-5p	88.335	NM_017742
ZCCHC2	hsa-miR-4325	88.2956	NM_017742
ZCCHC2	hsa-miR-1912-3p	86.5566	NM_017742
ZCCHC2	hsa-miR-379-5p	86.5235	NM_017742
ZCCHC2	hsa-miR-545-5p	85.9571	NM_017742
ZCCHC2	hsa-miR-5680	85.8665	NM_017742

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating ZCCHC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZCCHC2	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
ZCCHC2	jaspar__MA1125.1	ZNF384 (directAnnotation).
ZCCHC2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ZCCHC2	transfac_pro__M01253	CNOT3 (directAnnotation).
ZCCHC2	transfac_pro__M02089	E2F3 (directAnnotation).
ZCCHC2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ZCCHC2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ZCCHC2	transfac_pro__M04916	TAF1 (directAnnotation).
ZCCHC2	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
ZCCHC2	transfac_pro__M12697	ZNF142 (directAnnotation).
ZCCHC2	metacluster_111.5	E4F1; E4F1 (directAnnotation).
ZCCHC2	jaspar__MA0748.2	YY2 (directAnnotation).
ZCCHC2	metacluster_7.13	ZFX (directAnnotation).
ZCCHC2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ZCCHC2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZCCHC2	cisbp__M00788	ZFY (inferredBy_Orthology).
ZCCHC2	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
ZCCHC2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ZCCHC2	hdpi__TIMELESS	TIMELESS (directAnnotation).
ZCCHC2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZCCHC2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ZCCHC2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ZCCHC2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZCCHC2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZCCHC2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ZCCHC2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZCCHC2	transfac_pro__M01199	TRIM28 (directAnnotation).
ZCCHC2	hdpi__ELF2	ELF2 (directAnnotation).
ZCCHC2	tfdimers__MD00038	TFAP2C (directAnnotation).
ZCCHC2	transfac_pro__M01861	ATF1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."