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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZCCHC10

Summary for ZCCHC10

Gene information	Gene symbol	ZCCHC10
	Ensembl ID	ENSG00000155329
	Entrez ID	54819
	Gene name	zinc finger CCHC-type containing 10
	Synonyms	FLJ20094
	Gene type	protein_coding
	UniProtAcc	Q8TBK6

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Dataset with differentially expressed gene: ZCCHC10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.285577	0.00e+00

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Expression of ZCCHC10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZCCHC10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZCCHC10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZCCHC10	hsa-miR-455-3p	98.4685	NM_001300822
ZCCHC10	hsa-miR-550a-5p	94.4549	NM_001308128
ZCCHC10	hsa-miR-1271-3p	94.4549	NM_001308128
ZCCHC10	hsa-miR-550a-3-5p	94.4549	NM_001308128
ZCCHC10	hsa-miR-520c-5p	91.8618	NM_001308128
ZCCHC10	hsa-miR-519a-5p	91.8618	NM_001308128
ZCCHC10	hsa-miR-518d-5p	91.8618	NM_001308128
ZCCHC10	hsa-miR-519b-5p	91.8618	NM_001308128
ZCCHC10	hsa-miR-522-5p	91.8618	NM_001308128
ZCCHC10	hsa-miR-526a-5p	91.8618	NM_001308128
ZCCHC10	hsa-miR-523-5p	91.8618	NM_001308128
ZCCHC10	hsa-miR-519c-5p	91.8618	NM_001308128
ZCCHC10	hsa-miR-518e-5p	91.8618	NM_001308128
ZCCHC10	hsa-miR-518f-5p	91.8618	NM_001308128
ZCCHC10	hsa-miR-3658	90.5309	NM_001308128
ZCCHC10	hsa-miR-6077	90.4256	NM_001300822
ZCCHC10	hsa-miR-148a-5p	88.5684	NM_001308128
ZCCHC10	hsa-miR-548f-3p	88.4625	NM_001300822
ZCCHC10	hsa-miR-548bc	88.4625	NM_001300822
ZCCHC10	hsa-miR-548a-3p	88.4625	NM_001300822
ZCCHC10	hsa-miR-1910-5p	87.9884	NM_001300822
ZCCHC10	hsa-miR-548ar-3p	87.6506	NM_001300822
ZCCHC10	hsa-miR-195-3p	87.0602	NM_001300822
ZCCHC10	hsa-miR-16-2-3p	87.0602	NM_001300822
ZCCHC10	hsa-miR-4778-3p	86.8928	NM_001308130
ZCCHC10	hsa-miR-410-3p	86.8146	NM_001308128
ZCCHC10	hsa-miR-548e-3p	84.9661	NM_001300822
ZCCHC10	hsa-miR-548az-3p	84.9661	NM_001300822
ZCCHC10	hsa-miR-30e-3p	84.3729	NM_001308128
ZCCHC10	hsa-miR-30d-3p	84.3729	NM_001308128
ZCCHC10	hsa-miR-30a-3p	84.3729	NM_001308128
ZCCHC10	hsa-miR-577	83.0947	NM_001300822
ZCCHC10	hsa-miR-5187-3p	83.0016	NM_001308130
ZCCHC10	hsa-miR-4639-3p	82.9571	NM_001308130
ZCCHC10	hsa-miR-335-3p	82.7036	NM_001308128
ZCCHC10	hsa-miR-3163	82.579	NM_001300822
ZCCHC10	hsa-miR-4495	81.8414	NM_001308128
ZCCHC10	hsa-miR-138-2-3p	81.7596	NM_001300822
ZCCHC10	hsa-miR-3928-3p	81.4473	NM_001308130
ZCCHC10	hsa-miR-4729	81.4334	NM_001300822
ZCCHC10	hsa-miR-204-5p	81.3997	NM_001308128
ZCCHC10	hsa-miR-211-5p	81.3997	NM_001308128
ZCCHC10	hsa-miR-3671	81.3628	NM_001300822
ZCCHC10	hsa-miR-4666b	81.0837	NM_001308128
ZCCHC10	hsa-miR-766-5p	80.9966	NM_001300822
ZCCHC10	hsa-miR-203a-3p	80.7188	NM_001308128
ZCCHC10	hsa-miR-4452	80.6524	NM_001308128
ZCCHC10	hsa-miR-548at-5p	80.6133	NM_001300822
ZCCHC10	hsa-miR-654-3p	80.0366	NM_001308128

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Motifs and transcription factors (TFs) regulating ZCCHC10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZCCHC10	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ZCCHC10	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."