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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZC3H6

Summary for ZC3H6

Gene information	Gene symbol	ZC3H6
	Ensembl ID	ENSG00000188177
	Entrez ID	376940
	Gene name	zinc finger CCCH-type containing 6
	Synonyms	FLJ41410\|FLJ45877\|KIAA2035\|ZC3HDC6
	Gene type	protein_coding
	UniProtAcc	P61129

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Dataset with differentially expressed gene: ZC3H6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	-0.304071	6.99e-09
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.251756	1.40e-44

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Expression of ZC3H6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZC3H6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZC3H6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZC3H6	hsa-miR-5011-5p	100	NM_198581
ZC3H6	hsa-miR-190a-3p	100	NM_198581
ZC3H6	hsa-miR-3163	99.9948	NM_198581
ZC3H6	hsa-miR-616-5p	99.931	NM_198581
ZC3H6	hsa-miR-373-5p	99.931	NM_198581
ZC3H6	hsa-miR-371b-5p	99.931	NM_198581
ZC3H6	hsa-miR-548t-5p	99.4829	NM_198581
ZC3H6	hsa-miR-548az-5p	99.4829	NM_198581
ZC3H6	hsa-miR-548c-3p	99.2053	NM_198581
ZC3H6	hsa-miR-335-3p	98.1267	NM_198581
ZC3H6	hsa-miR-3613-3p	98.0353	NM_198581
ZC3H6	hsa-miR-5692a	97.9429	NM_198581
ZC3H6	hsa-miR-371a-5p	97.7962	NM_198581
ZC3H6	hsa-miR-7159-3p	97.7648	NM_198581
ZC3H6	hsa-miR-1206	97.6261	NM_198581
ZC3H6	hsa-miR-7844-5p	96.5441	NM_198581
ZC3H6	hsa-miR-499b-3p	96.2779	NM_198581
ZC3H6	hsa-miR-499a-3p	96.2779	NM_198581
ZC3H6	hsa-miR-302f	95.9165	NM_198581
ZC3H6	hsa-miR-144-3p	94.6265	NM_198581
ZC3H6	hsa-miR-664b-3p	93.9472	NM_198581
ZC3H6	hsa-miR-579-3p	93.9472	NM_198581
ZC3H6	hsa-miR-656-3p	93.7681	NM_198581
ZC3H6	hsa-miR-548at-5p	93.7609	NM_198581
ZC3H6	hsa-miR-4801	93.6403	NM_198581
ZC3H6	hsa-miR-200c-3p	93.1843	NM_198581
ZC3H6	hsa-miR-429	93.1843	NM_198581
ZC3H6	hsa-miR-200b-3p	93.1843	NM_198581
ZC3H6	hsa-miR-3149	93.1825	NM_198581
ZC3H6	hsa-miR-4731-3p	92.1423	NM_198581
ZC3H6	hsa-miR-6766-3p	91.8171	NM_198581
ZC3H6	hsa-miR-4782-3p	91.8171	NM_198581
ZC3H6	hsa-miR-219a-5p	91.8171	NM_198581
ZC3H6	hsa-miR-4666a-3p	91.0541	NM_198581
ZC3H6	hsa-miR-95-5p	90.9169	NM_198581
ZC3H6	hsa-miR-340-5p	90.4379	NM_198581
ZC3H6	hsa-miR-3941	90.4043	NM_198581
ZC3H6	hsa-miR-6793-3p	90.3265	NM_198581
ZC3H6	hsa-miR-590-3p	90.1388	NM_198581
ZC3H6	hsa-miR-192-3p	88.8857	NM_198581
ZC3H6	hsa-miR-12136	88.4319	NM_198581
ZC3H6	hsa-miR-4320	88.3332	NM_198581
ZC3H6	hsa-miR-1279	88.326	NM_198581
ZC3H6	hsa-miR-6827-3p	88.1827	NM_198581
ZC3H6	hsa-miR-466	87.8709	NM_198581
ZC3H6	hsa-miR-510-3p	87.8073	NM_198581
ZC3H6	hsa-miR-203a-5p	87.8001	NM_198581
ZC3H6	hsa-miR-890	87.4537	NM_198581
ZC3H6	hsa-miR-433-3p	87.38	NM_198581
ZC3H6	hsa-miR-4282	86.7731	NM_198581

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Motifs and transcription factors (TFs) regulating ZC3H6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZC3H6	transfac_pro__M01861	ATF1 (directAnnotation).
ZC3H6	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
ZC3H6	jaspar__MA1596.1	ZNF460 (directAnnotation).
ZC3H6	metacluster_141.2	E2F2; E2F3 (directAnnotation).
ZC3H6	transfac_pro__M06115	ZNF28 (directAnnotation).
ZC3H6	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
ZC3H6	kznf__ZNF334_Imbeault2017_RP_RCADE	ZNF334 (directAnnotation).
ZC3H6	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
ZC3H6	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
ZC3H6	jaspar__MA1106.1	HIF1A (directAnnotation).
ZC3H6	metacluster_31.3	ZSCAN20; ZSCAN29 (directAnnotation).
ZC3H6	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."