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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZC3H14

Summary for ZC3H14

Gene information	Gene symbol	ZC3H14
	Ensembl ID	ENSG00000100722
	Entrez ID	79882
	Gene name	zinc finger CCCH-type containing 14
	Synonyms	FLJ11806\|NY-REN-37\|UKp68
	Gene type	protein_coding
	UniProtAcc	Q6PJT7

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Dataset with differentially expressed gene: ZC3H14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.317465	1.83e-09
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.259466	2.30e-16

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Expression of ZC3H14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZC3H14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZC3H14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZC3H14	hsa-miR-497-3p	98.9418	NM_001160104
ZC3H14	hsa-miR-3942-3p	97.3139	NM_001160103
ZC3H14	hsa-miR-4775	95.3969	NM_001160103
ZC3H14	hsa-miR-6874-3p	94.6936	NM_001160104
ZC3H14	hsa-miR-148b-5p	94.6936	NM_001160104
ZC3H14	hsa-miR-3182	94.6411	NM_001160103
ZC3H14	hsa-miR-6739-3p	93.9806	NM_001160104
ZC3H14	hsa-miR-133b	93.8562	NM_001160103
ZC3H14	hsa-miR-133a-3p	93.8562	NM_001160103
ZC3H14	hsa-miR-5699-5p	92.233	NM_001160104
ZC3H14	hsa-miR-215-3p	92.0362	NM_001160104
ZC3H14	hsa-miR-6074	89.5785	NM_001160103
ZC3H14	hsa-miR-3613-3p	88.9968	NM_001160104
ZC3H14	hsa-miR-3149	88.3673	NM_001160103
ZC3H14	hsa-miR-30d-3p	87.1849	NM_001160103
ZC3H14	hsa-miR-30e-3p	87.1849	NM_001160103
ZC3H14	hsa-miR-30a-3p	87.1849	NM_001160103
ZC3H14	hsa-miR-488-5p	83.3518	NM_001160104
ZC3H14	hsa-miR-5010-3p	82.9907	NM_001160103
ZC3H14	hsa-miR-4659b-3p	82.7531	NM_001160103
ZC3H14	hsa-miR-4659a-3p	82.7531	NM_001160103
ZC3H14	hsa-miR-607	82.6153	NM_001160104
ZC3H14	hsa-miR-4713-5p	81.339	NM_001160104

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Motifs and transcription factors (TFs) regulating ZC3H14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZC3H14	transfac_public__M00024	E2F1 (directAnnotation).
ZC3H14	transfac_pro__M04950	EGR1 (directAnnotation).
ZC3H14	transfac_pro__M04862	NRF1 (directAnnotation).
ZC3H14	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ZC3H14	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ZC3H14	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."