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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZC3H11A

Summary for ZC3H11A

Gene information	Gene symbol	ZC3H11A
	Ensembl ID	ENSG00000058673
	Entrez ID	9877
	Gene name	zinc finger CCCH-type containing 11A
	Synonyms	KIAA0663\|ZC3HDC11A
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ZC3H11A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.260335	0.00e+00

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Expression of ZC3H11A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZC3H11A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZC3H11A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZC3H11A	hsa-miR-186-5p	99.6962	NM_014827
ZC3H11A	hsa-miR-4328	97.8699	NM_014827
ZC3H11A	hsa-miR-133b	94.8398	NM_001319238
ZC3H11A	hsa-miR-133a-3p	94.8398	NM_001319238
ZC3H11A	hsa-miR-7854-3p	93.9185	NM_001319238
ZC3H11A	hsa-miR-3529-3p	93.3463	NM_014827
ZC3H11A	hsa-miR-548e-5p	93.0255	NM_001319238
ZC3H11A	hsa-miR-660-3p	92.2797	NM_014827
ZC3H11A	hsa-miR-3685	91.6254	NM_001319238
ZC3H11A	hsa-miR-101-3p	91.5365	NM_001319238
ZC3H11A	hsa-miR-582-5p	90.8966	NM_001319238
ZC3H11A	hsa-miR-144-3p	89.8914	NM_001319238
ZC3H11A	hsa-miR-4666a-3p	87.8997	NM_001319238
ZC3H11A	hsa-miR-9-3p	87.7585	NM_001319238
ZC3H11A	hsa-miR-503-3p	87.638	NM_014827
ZC3H11A	hsa-miR-6856-3p	87.3027	NM_014827
ZC3H11A	hsa-miR-4257	85.9313	NM_014827
ZC3H11A	hsa-miR-6507-5p	84.85	NM_014827
ZC3H11A	hsa-miR-3185	84.626	NM_014827
ZC3H11A	hsa-miR-3671	84.5844	NM_001319238
ZC3H11A	hsa-miR-4260	83.467	NM_014827
ZC3H11A	hsa-miR-4460	83.4602	NM_001319238
ZC3H11A	hsa-miR-3120-3p	82.9901	NM_014827
ZC3H11A	hsa-miR-335-3p	82.5919	NM_001319238
ZC3H11A	hsa-miR-218-2-3p	82.4165	NM_014827
ZC3H11A	hsa-miR-153-5p	82.3233	NM_014827
ZC3H11A	hsa-miR-5002-5p	81.4167	NM_001319238
ZC3H11A	hsa-miR-10527-5p	80.898	NM_014827
ZC3H11A	hsa-miR-3059-5p	80.8888	NM_001319238
ZC3H11A	hsa-let-7f-1-3p	80.7932	NM_001319238
ZC3H11A	hsa-let-7b-3p	80.7932	NM_001319238
ZC3H11A	hsa-let-7a-3p	80.7932	NM_001319238
ZC3H11A	hsa-miR-98-3p	80.7932	NM_001319238
ZC3H11A	hsa-miR-9900	80.5811	NM_014827
ZC3H11A	hsa-miR-4750-3p	80.3977	NM_001319238
ZC3H11A	hsa-miR-4306	80.2181	NM_014827

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Motifs and transcription factors (TFs) regulating ZC3H11A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZC3H11A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZC3H11A	transfac_pro__M07397	ZNF148 (directAnnotation).
ZC3H11A	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ZC3H11A	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
ZC3H11A	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ZC3H11A	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ZC3H11A	transfac_pro__M01175	ZBTB7B (directAnnotation).
ZC3H11A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ZC3H11A	tfdimers__MD00151	CHURC1 (directAnnotation).
ZC3H11A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ZC3H11A	transfac_pro__M01303	SP1 (directAnnotation).
ZC3H11A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZC3H11A	transfac_pro__M01714	KLF15 (directAnnotation).
ZC3H11A	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ZC3H11A	metacluster_3.14	WT1; WT1 (directAnnotation).
ZC3H11A	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ZC3H11A	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ZC3H11A	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ZC3H11A	transfac_pro__M02281	SP1 (directAnnotation).
ZC3H11A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZC3H11A	transfac_public__M00491	PATZ1 (directAnnotation).
ZC3H11A	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."