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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZC2HC1A

Summary for ZC2HC1A

Gene information	Gene symbol	ZC2HC1A
	Ensembl ID	ENSG00000104427
	Entrez ID	51101
	Gene name	zinc finger C2HC-type containing 1A
	Synonyms	C8orf70\|CGI-62\|FAM164A
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ZC2HC1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.377465	5.56e-10

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Expression of ZC2HC1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZC2HC1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZC2HC1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZC2HC1A	hsa-miR-3942-3p	96.0141	NM_016010
ZC2HC1A	hsa-miR-5692a	96.0017	NM_016010
ZC2HC1A	hsa-miR-511-5p	94.3636	NM_016010
ZC2HC1A	hsa-miR-577	94.2021	NM_016010
ZC2HC1A	hsa-miR-4526	93.9468	NM_016010
ZC2HC1A	hsa-miR-3660	93.9468	NM_016010
ZC2HC1A	hsa-miR-513a-3p	92.0662	NM_016010
ZC2HC1A	hsa-miR-513c-3p	92.0662	NM_016010
ZC2HC1A	hsa-miR-581	90.609	NM_016010
ZC2HC1A	hsa-miR-196a-1-3p	90.2915	NM_016010
ZC2HC1A	hsa-miR-8485	89.9033	NM_016010
ZC2HC1A	hsa-miR-3120-3p	89.8045	NM_016010
ZC2HC1A	hsa-miR-16-1-3p	89.2948	NM_016010
ZC2HC1A	hsa-miR-3606-3p	89.21	NM_016010
ZC2HC1A	hsa-miR-367-3p	89.0217	NM_016010
ZC2HC1A	hsa-miR-190a-3p	88.6735	NM_016010
ZC2HC1A	hsa-miR-4464	88.0384	NM_016010
ZC2HC1A	hsa-miR-4711-3p	87.5856	NM_016010
ZC2HC1A	hsa-miR-4637	87.5534	NM_016010
ZC2HC1A	hsa-miR-363-3p	86.6413	NM_016010
ZC2HC1A	hsa-miR-25-3p	86.6413	NM_016010
ZC2HC1A	hsa-miR-4748	86.4022	NM_016010
ZC2HC1A	hsa-miR-1185-2-3p	86.0555	NM_016010
ZC2HC1A	hsa-let-7f-2-3p	86.0555	NM_016010
ZC2HC1A	hsa-miR-1185-1-3p	86.0555	NM_016010
ZC2HC1A	hsa-miR-4712-3p	86.0376	NM_016010
ZC2HC1A	hsa-miR-32-5p	85.8838	NM_016010
ZC2HC1A	hsa-miR-92b-3p	85.8838	NM_016010
ZC2HC1A	hsa-miR-92a-3p	85.8838	NM_016010
ZC2HC1A	hsa-miR-3671	85.846	NM_016010
ZC2HC1A	hsa-miR-205-3p	85.6577	NM_016010
ZC2HC1A	hsa-miR-3688-3p	85.4197	NM_016010
ZC2HC1A	hsa-miR-892c-5p	84.9229	NM_016010
ZC2HC1A	hsa-miR-586	84.445	NM_016010
ZC2HC1A	hsa-miR-144-3p	83.8939	NM_016010
ZC2HC1A	hsa-miR-15b-5p	83.7092	NM_016010
ZC2HC1A	hsa-miR-3121-3p	83.2781	NM_016010
ZC2HC1A	hsa-miR-7155-5p	83.1498	NM_016010
ZC2HC1A	hsa-miR-374b-3p	83.0365	NM_016010
ZC2HC1A	hsa-miR-4753-3p	82.7058	NM_016010
ZC2HC1A	hsa-miR-1277-5p	81.6033	NM_016010
ZC2HC1A	hsa-miR-3129-3p	80.5569	NM_016010
ZC2HC1A	hsa-miR-5583-5p	80.5569	NM_016010
ZC2HC1A	hsa-miR-5585-3p	80.3011	NM_016010
ZC2HC1A	hsa-miR-424-5p	80.2415	NM_016010
ZC2HC1A	hsa-miR-6838-5p	80.2415	NM_016010
ZC2HC1A	hsa-miR-195-5p	80.2415	NM_016010
ZC2HC1A	hsa-miR-497-5p	80.2415	NM_016010
ZC2HC1A	hsa-miR-16-5p	80.2415	NM_016010
ZC2HC1A	hsa-miR-15a-5p	80.2415	NM_016010

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Motifs and transcription factors (TFs) regulating ZC2HC1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZC2HC1A	metacluster_136.2	RFX1; RFX2; RFX2; RFX3; RFX3; RFX4; RFX5; RFX5; RFX5; RFX5; RFX5; RFX5; RFX5; RFX7; RFX7; RFXANK; RFXAP (directAnnotation). RFX3; RFX3; RFX4 (inferredBy_Orthology).
ZC2HC1A	jaspar__MA1724.1	RFX6 (inferredBy_Orthology).
ZC2HC1A	transfac_pro__M05815	ZNF613 (directAnnotation).
ZC2HC1A	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
ZC2HC1A	tfdimers__MD00557	MZF1 (directAnnotation).
ZC2HC1A	transfac_pro__M06251	ZSCAN2 (inferredBy_Orthology).
ZC2HC1A	metacluster_136.3	MAX; MXI1; MXI1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX4; RFX4; RFX4; RFX4; RFX5; RFX5; RFX5; SREBF1; ZBTB7B (directAnnotation). RFX1; RFX1; RFX1; RFX1; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX3; RFX3; RFX3; RFX3; RFX3; RFX4; RFX4; RFX4; RFX6; RFX6; RFX6; RFX7; RFX8; RFX8 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."