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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: ZBTB38

Summary for ZBTB38

Gene informationGene symbol

ZBTB38

Ensembl ID

ENSG00000177311

Entrez ID

253461

Gene namezinc finger and BTB domain containing 38
SynonymsCIBZ|FLJ35036|PPP1R171|ZNF921
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: ZBTB38

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD8+ T cells0.2918212.41e-38

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMalignant cells0.603490.00e+00

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreCD8+ T cells0.3841180.00e+00

GSE131984_Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapypalbociclibNAMalignant cells0.2873957.87e-08

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepreMalignant cells0.259350.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.7492490.00e+00

GSE164897_VemCob

A375 cell lineCell lineMelanomaBRAFV600E-mutant melanomaTargeted therapyvemurafenib + combimetinibNAMalignant cells-0.3728740.00e+00

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Expression of ZBTB38 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to ZBTB38

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZBTB38

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
ZBTB38hsa-miR-548as-3p98.7838NM_001080412
ZBTB38hsa-miR-568398.3186NM_001080412
ZBTB38hsa-miR-4684-5p97.8204NM_001080412
ZBTB38hsa-miR-469896.4018NM_001080412
ZBTB38hsa-miR-493-5p93.0195NM_001080412
ZBTB38hsa-miR-3160-5p92.9608NM_001080412
ZBTB38hsa-miR-316392.6931NM_001080412
ZBTB38hsa-miR-4778-3p89.1591NM_001080412
ZBTB38hsa-miR-590-3p87.9225NM_001080412
ZBTB38hsa-miR-200c-3p87.3596NM_001080412
ZBTB38hsa-miR-200b-3p87.3596NM_001080412
ZBTB38hsa-miR-42987.3596NM_001080412
ZBTB38hsa-miR-135b-3p86.5276NM_001080412
ZBTB38hsa-miR-135a-2-3p86.5276NM_001080412
ZBTB38hsa-miR-190a-3p85.9264NM_001080412
ZBTB38hsa-miR-155-5p85.7659NM_001080412
ZBTB38hsa-miR-364684.9537NM_001080412
ZBTB38hsa-miR-20a-3p84.6871NM_001080412
ZBTB38hsa-miR-60183.4654NM_001080412
ZBTB38hsa-miR-323b-3p83.3999NM_001080412
ZBTB38hsa-miR-452883.1099NM_001080412
ZBTB38hsa-miR-374b-3p82.9185NM_001080412
ZBTB38hsa-miR-4661-3p81.6366NM_001080412
ZBTB38hsa-miR-4766-3p81.0767NM_001080412
ZBTB38hsa-miR-129980.654NM_001080412
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Motifs and transcription factors (TFs) regulating ZBTB38

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
ZBTB38taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_CAPHOXB13; ONECUT2 (directAnnotation).
ZBTB38hocomoco__PATZ1_HUMAN.H11MO.1.CPATZ1 (directAnnotation).
ZBTB38jaspar__MA1483.2ELF2 (directAnnotation).
ZBTB38taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAPETV4; HOXB2 (directAnnotation).
ZBTB38taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAPETV1; HOXB2 (directAnnotation).
ZBTB38dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1GMEB1 (directAnnotation).
ZBTB38taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAPETV2; TEF (directAnnotation).
ZBTB38jaspar__MA1955.1FOXO1 (directAnnotation).
ZBTB38jaspar__MA1954.1FOXO1 (directAnnotation).
ZBTB38jaspar__MA1953.1FOXO1 (directAnnotation).
ZBTB38jaspar__MA1956.1FOXO1 (directAnnotation).
ZBTB38taipale_tf_pairs__FOXO1_ETV4_RWMAACAGGAARNN_CAPETV4; FOXO1 (directAnnotation).
ZBTB38homer__ACAGGATGTGGT_ETS_RUNXRUNX1 (directAnnotation).
ZBTB38transfac_pro__M05791ZNF517 (directAnnotation).
ZBTB38swissregulon__mm__Elf3ELF3 (inferredBy_Orthology).
ZBTB38jaspar__MA0776.1MYBL1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."