Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: YY1AP1

Summary for YY1AP1

Gene information	Gene symbol	YY1AP1
	Ensembl ID	ENSG00000163374
	Entrez ID	55249
	Gene name	YY1 associated protein 1
	Synonyms	HCCA2\|YAP\|YY1AP
	Gene type	protein_coding
	UniProtAcc	Q9H869

Top

Dataset with differentially expressed gene: YY1AP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.382588	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.259625	4.22e-12

Top

Expression of YY1AP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to YY1AP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating YY1AP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YY1AP1	hsa-miR-4492	97.9018	NM_001198906
YY1AP1	hsa-miR-762	97.0541	NM_001198906
YY1AP1	hsa-miR-4498	97.0439	NM_001198906
YY1AP1	hsa-miR-2110	96.3811	NM_001198906
YY1AP1	hsa-miR-5001-5p	95.3606	NM_001198906
YY1AP1	hsa-miR-1193	94.1134	NM_001198906
YY1AP1	hsa-miR-7155-5p	92.9843	NM_001198902
YY1AP1	hsa-miR-4430	90.6527	NM_001198906
YY1AP1	hsa-miR-3652	90.6527	NM_001198906
YY1AP1	hsa-miR-450a-2-3p	89.6761	NM_001198906
YY1AP1	hsa-miR-6165	88.8547	NM_001198906
YY1AP1	hsa-miR-3059-5p	88.5255	NM_001198906
YY1AP1	hsa-miR-4725-3p	87.5793	NM_001198906
YY1AP1	hsa-miR-6780b-5p	87.5793	NM_001198906
YY1AP1	hsa-miR-4271	86.2655	NM_001198906
YY1AP1	hsa-miR-193b-5p	85.9858	NM_001198906
YY1AP1	hsa-miR-4283	84.1758	NM_001198906
YY1AP1	hsa-miR-486-3p	83.2125	NM_001198906
YY1AP1	hsa-miR-4651	82.1785	NM_001198906
YY1AP1	hsa-miR-608	82.1785	NM_001198906
YY1AP1	hsa-miR-6721-5p	82.0832	NM_001198906
YY1AP1	hsa-miR-219a-1-3p	81.937	NM_001198906
YY1AP1	hsa-miR-6835-3p	80.7892	NM_001198902

Page: 1

Top

Motifs and transcription factors (TFs) regulating YY1AP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."