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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: YWHAQ

Summary for YWHAQ

Gene information	Gene symbol	YWHAQ
	Ensembl ID	ENSG00000134308
	Entrez ID	10971
	Gene name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
	Synonyms	14-3-3\|HS1
	Gene type	protein_coding
	UniProtAcc	P27348

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Dataset with differentially expressed gene: YWHAQ

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.405481	6.01e-05
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.319891	7.76e-28
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.871673	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.328807	2.80e-45
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.274583	8.45e-22
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.26119	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.389775	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.16053	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.342769	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.288904	1.12e-19
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.254274	7.38e-11
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.331904	2.34e-21
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.268016	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	CD4+ T cells	-0.308017	2.88e-02
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	CD8+ T cells	-0.332156	1.82e-44
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.459875	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.608276	0.00e+00

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Expression of YWHAQ in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to YWHAQ

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating YWHAQ

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YWHAQ	hsa-miR-6124	97.7732	NM_006826
YWHAQ	hsa-miR-651-3p	96.7131	NM_006826
YWHAQ	hsa-miR-3668	96.4622	NM_006826
YWHAQ	hsa-miR-4643	94.7963	NM_006826
YWHAQ	hsa-miR-548av-5p	94.7692	NM_006826
YWHAQ	hsa-miR-548k	94.7692	NM_006826
YWHAQ	hsa-miR-8054	94.7692	NM_006826
YWHAQ	hsa-miR-4491	94.3037	NM_006826
YWHAQ	hsa-miR-4657	94.3037	NM_006826
YWHAQ	hsa-miR-4496	93.8568	NM_006826
YWHAQ	hsa-miR-224-3p	93.8509	NM_006826
YWHAQ	hsa-miR-522-3p	93.8509	NM_006826
YWHAQ	hsa-miR-6785-5p	93.7321	NM_006826
YWHAQ	hsa-miR-4728-5p	93.7321	NM_006826
YWHAQ	hsa-miR-520d-5p	93.5124	NM_006826
YWHAQ	hsa-miR-524-5p	93.5124	NM_006826
YWHAQ	hsa-miR-3148	93.0831	NM_006826
YWHAQ	hsa-miR-6883-5p	92.6083	NM_006826
YWHAQ	hsa-miR-149-3p	92.6083	NM_006826
YWHAQ	hsa-miR-890	92.4396	NM_006826
YWHAQ	hsa-miR-587	92.2026	NM_006826
YWHAQ	hsa-miR-27b-3p	91.5177	NM_006826
YWHAQ	hsa-miR-27a-3p	91.5177	NM_006826
YWHAQ	hsa-miR-9985	91.5177	NM_006826
YWHAQ	hsa-miR-5003-3p	91.1054	NM_006826
YWHAQ	hsa-miR-6780a-5p	90.5275	NM_006826
YWHAQ	hsa-miR-3913-5p	90.502	NM_006826
YWHAQ	hsa-miR-548u	90.0693	NM_006826
YWHAQ	hsa-miR-7161-5p	90.0693	NM_006826
YWHAQ	hsa-miR-12124	89.4585	NM_006826
YWHAQ	hsa-miR-3609	89.3107	NM_006826
YWHAQ	hsa-miR-548ah-5p	89.3107	NM_006826
YWHAQ	hsa-miR-5586-3p	89.1626	NM_006826
YWHAQ	hsa-miR-30b-3p	88.3326	NM_006826
YWHAQ	hsa-miR-3122	87.5204	NM_006826
YWHAQ	hsa-miR-6830-5p	87.4523	NM_006826
YWHAQ	hsa-miR-449c-3p	87.0613	NM_006826
YWHAQ	hsa-miR-6779-5p	86.7756	NM_006826
YWHAQ	hsa-miR-3689c	86.7756	NM_006826
YWHAQ	hsa-miR-3689a-3p	86.7756	NM_006826
YWHAQ	hsa-miR-1273h-5p	86.7756	NM_006826
YWHAQ	hsa-miR-3689b-3p	86.7756	NM_006826
YWHAQ	hsa-miR-613	86.714	NM_006826
YWHAQ	hsa-miR-206	86.714	NM_006826
YWHAQ	hsa-miR-1-3p	86.714	NM_006826
YWHAQ	hsa-miR-4789-3p	86.6065	NM_006826
YWHAQ	hsa-miR-4457	86.397	NM_006826
YWHAQ	hsa-miR-12120	85.3877	NM_006826
YWHAQ	hsa-miR-223-5p	84.2073	NM_006826
YWHAQ	hsa-miR-8485	83.2538	NM_006826

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Motifs and transcription factors (TFs) regulating YWHAQ

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YWHAQ	metacluster_151.2	ZNF23 (directAnnotation).
YWHAQ	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
YWHAQ	transfac_pro__M05479	ZNF580 (directAnnotation).
YWHAQ	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
YWHAQ	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
YWHAQ	jaspar__MA0079.5	SP1 (directAnnotation).
YWHAQ	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
YWHAQ	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
YWHAQ	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
YWHAQ	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
YWHAQ	jaspar__MA1122.1	TFDP1 (directAnnotation).
YWHAQ	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
YWHAQ	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
YWHAQ	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
YWHAQ	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
YWHAQ	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
YWHAQ	transfac_pro__M07436	WT1 (directAnnotation).
YWHAQ	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
YWHAQ	transfac_pro__M00716	ZBTB14 (directAnnotation).
YWHAQ	swissregulon__hs__CHD1	CHD1 (directAnnotation).
YWHAQ	hdpi__HIP2	UBE2K (directAnnotation).
YWHAQ	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
YWHAQ	transfac_pro__M04893	TAF1 (directAnnotation).
YWHAQ	transfac_pro__M03876	ZBTB33 (directAnnotation).
YWHAQ	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
YWHAQ	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
YWHAQ	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
YWHAQ	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
YWHAQ	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
YWHAQ	transfac_pro__M05513	ZNF641 (inferredBy_Orthology).
YWHAQ	transfac_pro__M06363	ZNF730 (directAnnotation).
YWHAQ	metacluster_22.28	BACH1 (directAnnotation).
YWHAQ	transfac_pro__M12441	ZNF281 (inferredBy_Orthology).
YWHAQ	transfac_pro__M06353	ZNF782 (directAnnotation).
YWHAQ	hocomoco__HSF1_MOUSE.H11MO.1.A	HSF1 (inferredBy_Orthology).
YWHAQ	transfac_pro__M06763	ZNF225 (directAnnotation).
YWHAQ	transfac_pro__M06104	ZNF16 (directAnnotation).
YWHAQ	taipale_tf_pairs__MYBL1_HOXA13_CTCRTAAAWNNNNRMCGTTR_CAP_repr	HOXA13; MYBL1 (directAnnotation).
YWHAQ	transfac_pro__M06257	ZNF616 (directAnnotation).
YWHAQ	jaspar__MA0776.1	MYBL1 (directAnnotation).
YWHAQ	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
YWHAQ	transfac_pro__M05560	AEBP2 (directAnnotation).
YWHAQ	kznf__ZNF777_Isakova2017_SMiLE-seq	ZNF777 (directAnnotation).
YWHAQ	tfdimers__MD00456	E2F6; OVOL2 (directAnnotation).
YWHAQ	jaspar__MA0502.2	NFYB (directAnnotation).
YWHAQ	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
YWHAQ	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
YWHAQ	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
YWHAQ	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
YWHAQ	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
YWHAQ	"Phenethyl Isothiocyanate"	DB12695	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."