Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: YWHAG

Summary for YWHAG

Gene information	Gene symbol	YWHAG
	Ensembl ID	ENSG00000170027
	Entrez ID	7532
	Gene name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
	Synonyms	14-3-3GAMMA\|PPP1R170
	Gene type	protein_coding
	UniProtAcc	P61981

Top

Dataset with differentially expressed gene: YWHAG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.490104	4.66e-02
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.726289	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.80505	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.29263	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.63739	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.499239	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.490534	1.48e-42
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.440266	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.65234	0.00e+00

Top

Expression of YWHAG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to YWHAG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating YWHAG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YWHAG	hsa-miR-3148	99.789	NM_012479
YWHAG	hsa-miR-4420	98.9257	NM_012479
YWHAG	hsa-miR-1288-5p	98.8488	NM_012479
YWHAG	hsa-miR-181b-2-3p	98.7714	NM_012479
YWHAG	hsa-miR-181b-3p	98.7714	NM_012479
YWHAG	hsa-miR-651-3p	98.6356	NM_012479
YWHAG	hsa-miR-653-3p	98.3055	NM_012479
YWHAG	hsa-miR-135b-5p	97.906	NM_012479
YWHAG	hsa-miR-135a-5p	97.906	NM_012479
YWHAG	hsa-miR-548av-3p	97.4212	NM_012479
YWHAG	hsa-miR-182-5p	95.8988	NM_012479
YWHAG	hsa-miR-889-5p	95.733	NM_012479
YWHAG	hsa-miR-4703-5p	94.8995	NM_012479
YWHAG	hsa-miR-3919	94.3392	NM_012479
YWHAG	hsa-miR-34b-3p	94.3248	NM_012479
YWHAG	hsa-miR-3942-5p	94.0339	NM_012479
YWHAG	hsa-miR-4524a-3p	93.975	NM_012479
YWHAG	hsa-miR-3684	93.8531	NM_012479
YWHAG	hsa-miR-4668-5p	93.6554	NM_012479
YWHAG	hsa-miR-6739-5p	93.5056	NM_012479
YWHAG	hsa-miR-200a-3p	93.364	NM_012479
YWHAG	hsa-miR-141-3p	93.364	NM_012479
YWHAG	hsa-miR-4470	92.6245	NM_012479
YWHAG	hsa-miR-96-5p	92.0826	NM_012479
YWHAG	hsa-miR-4687-3p	91.6663	NM_012479
YWHAG	hsa-miR-190a-3p	91.6656	NM_012479
YWHAG	hsa-miR-7158-5p	91.4107	NM_012479
YWHAG	hsa-miR-140-3p	91.1469	NM_012479
YWHAG	hsa-miR-5011-5p	91.1145	NM_012479
YWHAG	hsa-miR-6733-5p	91.0841	NM_012479
YWHAG	hsa-miR-429	90.6049	NM_012479
YWHAG	hsa-miR-200b-3p	90.6049	NM_012479
YWHAG	hsa-miR-200c-3p	90.6049	NM_012479
YWHAG	hsa-miR-1271-5p	90.5359	NM_012479
YWHAG	hsa-miR-12133	90.5359	NM_012479
YWHAG	hsa-miR-7974	89.9363	NM_012479
YWHAG	hsa-miR-122b-5p	89.9273	NM_012479
YWHAG	hsa-miR-6798-3p	89.8528	NM_012479
YWHAG	hsa-miR-3153	89.7265	NM_012479
YWHAG	hsa-miR-4451	89.6694	NM_012479
YWHAG	hsa-miR-144-3p	89.5818	NM_012479
YWHAG	hsa-miR-4306	89.4572	NM_012479
YWHAG	hsa-miR-7161-5p	88.6784	NM_012479
YWHAG	hsa-miR-5002-5p	87.9686	NM_012479
YWHAG	hsa-miR-765	87.8746	NM_012479
YWHAG	hsa-miR-4644	87.5961	NM_012479
YWHAG	hsa-miR-185-5p	87.5961	NM_012479
YWHAG	hsa-miR-3925-5p	87.2659	NM_012479
YWHAG	hsa-miR-6884-3p	86.3865	NM_012479
YWHAG	hsa-miR-6804-3p	86.1648	NM_012479

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating YWHAG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YWHAG	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
YWHAG	jaspar__MA0079.5	SP1 (directAnnotation).
YWHAG	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
YWHAG	transfac_pro__M04950	EGR1 (directAnnotation).
YWHAG	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
YWHAG	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
YWHAG	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
YWHAG	jaspar__MA1122.1	TFDP1 (directAnnotation).
YWHAG	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
YWHAG	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
YWHAG	transfac_pro__M04617	ZBTB7A (directAnnotation).
YWHAG	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
YWHAG	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
YWHAG	transfac_pro__M07387	ZBTB7A (directAnnotation).
YWHAG	transfac_pro__M07436	WT1 (directAnnotation).
YWHAG	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
YWHAG	swissregulon__hs__CHD1	CHD1 (directAnnotation).
YWHAG	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
YWHAG	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
YWHAG	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
YWHAG	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
YWHAG	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
YWHAG	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
YWHAG	transfac_pro__M01122	ZNF219 (directAnnotation).
YWHAG	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
YWHAG	cisbp__M00249	WT1 (directAnnotation).
YWHAG	swissregulon__hs__KLF6	KLF6 (directAnnotation).
YWHAG	transfac_pro__M01303	SP1 (directAnnotation).
YWHAG	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
YWHAG	transfac_pro__M07397	ZNF148 (directAnnotation).
YWHAG	transfac_pro__M12686	ZBTB10 (directAnnotation).
YWHAG	transfac_pro__M01104	OVOL2 (directAnnotation).
YWHAG	transfac_pro__M00986	CHURC1 (directAnnotation).
YWHAG	transfac_pro__M04918	EGR1 (directAnnotation).
YWHAG	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
YWHAG	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
YWHAG	transfac_pro__M04748	GABPA (directAnnotation).
YWHAG	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
YWHAG	transfac_pro__M01253	CNOT3 (directAnnotation).
YWHAG	transfac_pro__M05697	ZNF235 (directAnnotation).
YWHAG	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
YWHAG	transfac_pro__M06249	ZNF616 (directAnnotation).
YWHAG	metacluster_102.2	ZBED1 (directAnnotation).
YWHAG	transfac_pro__M05711	ZNF37A (directAnnotation).
YWHAG	metacluster_112.5	HOXA4; PAX3; PAX7; PAX7 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."