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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: YTHDF1

Summary for YTHDF1

Gene information	Gene symbol	YTHDF1
	Ensembl ID	ENSG00000149658
	Entrez ID	54915
	Gene name	YTH N6-methyladenosine RNA binding protein 1
	Synonyms	C20orf21\|FLJ20391
	Gene type	protein_coding
	UniProtAcc	Q9BYJ9

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Dataset with differentially expressed gene: YTHDF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.276602	9.01e-42
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.326867	0.00e+00

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Expression of YTHDF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to YTHDF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating YTHDF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YTHDF1	hsa-miR-4727-5p	97.5725	NM_017798
YTHDF1	hsa-miR-622	97.4161	NM_017798
YTHDF1	hsa-miR-369-3p	96.7143	NM_017798
YTHDF1	hsa-miR-1285-3p	96.0237	NM_017798
YTHDF1	hsa-miR-5189-5p	96.0237	NM_017798
YTHDF1	hsa-miR-6882-5p	95.0797	NM_017798
YTHDF1	hsa-miR-612	94.9671	NM_017798
YTHDF1	hsa-miR-6860	94.9671	NM_017798
YTHDF1	hsa-miR-3187-5p	94.9671	NM_017798
YTHDF1	hsa-miR-6847-5p	94.8999	NM_017798
YTHDF1	hsa-miR-376c-3p	94.7346	NM_017798
YTHDF1	hsa-miR-4310	94.6875	NM_017798
YTHDF1	hsa-miR-7157-5p	94.6514	NM_017798
YTHDF1	hsa-miR-548aj-3p	94.4252	NM_017798
YTHDF1	hsa-miR-548x-3p	94.4252	NM_017798
YTHDF1	hsa-miR-6817-5p	93.7258	NM_017798
YTHDF1	hsa-miR-4769-3p	93.7258	NM_017798
YTHDF1	hsa-miR-6738-3p	93.594	NM_017798
YTHDF1	hsa-miR-548j-3p	92.6053	NM_017798
YTHDF1	hsa-miR-548am-3p	92.6053	NM_017798
YTHDF1	hsa-miR-548ah-3p	92.6053	NM_017798
YTHDF1	hsa-miR-548ae-3p	92.6053	NM_017798
YTHDF1	hsa-miR-548aq-3p	92.6053	NM_017798
YTHDF1	hsa-miR-3613-3p	91.5375	NM_017798
YTHDF1	hsa-miR-1305	90.2754	NM_017798
YTHDF1	hsa-miR-193a-5p	89.9049	NM_017798
YTHDF1	hsa-miR-346	89.7863	NM_017798
YTHDF1	hsa-miR-4257	88.8573	NM_017798
YTHDF1	hsa-miR-1182	87.5652	NM_017798
YTHDF1	hsa-miR-12136	86.804	NM_017798
YTHDF1	hsa-miR-548z	86.2178	NM_017798
YTHDF1	hsa-miR-548bb-3p	86.2178	NM_017798
YTHDF1	hsa-miR-548h-3p	86.2178	NM_017798
YTHDF1	hsa-miR-548d-3p	86.2178	NM_017798
YTHDF1	hsa-miR-548ac	86.2178	NM_017798
YTHDF1	hsa-miR-921	85.68	NM_017798
YTHDF1	hsa-miR-421	85.15	NM_017798
YTHDF1	hsa-miR-9-3p	85.1261	NM_017798
YTHDF1	hsa-miR-3692-3p	84.5625	NM_017798
YTHDF1	hsa-miR-3606-5p	84.4773	NM_017798
YTHDF1	hsa-miR-374a-5p	84.407	NM_017798
YTHDF1	hsa-miR-548k	83.9034	NM_017798
YTHDF1	hsa-miR-8054	83.9034	NM_017798
YTHDF1	hsa-miR-548av-5p	83.9034	NM_017798
YTHDF1	hsa-miR-1255b-5p	83.0234	NM_017798
YTHDF1	hsa-miR-1255a	83.0234	NM_017798
YTHDF1	hsa-miR-548c-3p	82.997	NM_017798
YTHDF1	hsa-miR-374b-5p	82.8955	NM_017798
YTHDF1	hsa-miR-194-5p	82.8879	NM_017798
YTHDF1	hsa-miR-6505-3p	82.7233	NM_017798

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Motifs and transcription factors (TFs) regulating YTHDF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YTHDF1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
YTHDF1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
YTHDF1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
YTHDF1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
YTHDF1	cisbp__M08198	ELF1 (directAnnotation).
YTHDF1	hdpi__ETV4	ETV4 (directAnnotation).
YTHDF1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
YTHDF1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."