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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: YPEL2

Summary for YPEL2

Gene information	Gene symbol	YPEL2
	Ensembl ID	ENSG00000175155
	Entrez ID	388403
	Gene name	yippee like 2
	Synonyms	FKSG4
	Gene type	protein_coding
	UniProtAcc	Q96QA6

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Dataset with differentially expressed gene: YPEL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.295566	3.33e-15

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Expression of YPEL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to YPEL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating YPEL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YPEL2	hsa-miR-30c-5p	96.8526	NM_001005404
YPEL2	hsa-miR-30a-5p	96.8526	NM_001005404
YPEL2	hsa-miR-30d-5p	96.8526	NM_001005404
YPEL2	hsa-miR-30e-5p	96.8526	NM_001005404
YPEL2	hsa-miR-30b-5p	96.8526	NM_001005404
YPEL2	hsa-miR-3663-3p	94.4639	NM_001005404
YPEL2	hsa-miR-498-5p	93.6005	NM_001005404
YPEL2	hsa-let-7c-3p	92.7742	NM_001005404
YPEL2	hsa-miR-6809-3p	92.713	NM_001005404
YPEL2	hsa-miR-202-3p	92.2647	NM_001005404
YPEL2	hsa-miR-656-3p	92.2272	NM_001005404
YPEL2	hsa-miR-5680	91.8862	NM_001005404
YPEL2	hsa-miR-570-3p	91.6317	NM_001005404
YPEL2	hsa-miR-4639-3p	91.5603	NM_001005404
YPEL2	hsa-miR-4524a-3p	91.4969	NM_001005404
YPEL2	hsa-miR-3157-5p	91.3896	NM_001005404
YPEL2	hsa-miR-432-3p	91.2238	NM_001005404
YPEL2	hsa-miR-4755-5p	90.5209	NM_001005404
YPEL2	hsa-miR-5006-3p	90.5209	NM_001005404
YPEL2	hsa-miR-4753-3p	89.9978	NM_001005404
YPEL2	hsa-miR-12125	89.9207	NM_001005404
YPEL2	hsa-miR-548g-3p	89.7843	NM_001005404
YPEL2	hsa-miR-6071	89.7522	NM_001005404
YPEL2	hsa-miR-330-3p	89.4514	NM_001005404
YPEL2	hsa-miR-6782-3p	88.6599	NM_001005404
YPEL2	hsa-miR-511-3p	88.3712	NM_001005404
YPEL2	hsa-miR-2355-3p	88.2109	NM_001005404
YPEL2	hsa-miR-627-3p	88.0732	NM_001005404
YPEL2	hsa-miR-520e-5p	87.8119	NM_001005404
YPEL2	hsa-miR-200b-3p	87.7855	NM_001005404
YPEL2	hsa-miR-200c-3p	87.7855	NM_001005404
YPEL2	hsa-miR-429	87.7855	NM_001005404
YPEL2	hsa-miR-223-5p	87.3602	NM_001005404
YPEL2	hsa-miR-659-3p	86.7403	NM_001005404
YPEL2	hsa-miR-4251	86.7247	NM_001005404
YPEL2	hsa-miR-6866-5p	86.2481	NM_001005404
YPEL2	hsa-miR-4446-5p	86.1822	NM_001005404
YPEL2	hsa-miR-204-5p	85.6618	NM_001005404
YPEL2	hsa-miR-211-5p	85.6618	NM_001005404
YPEL2	hsa-miR-4715-3p	85.1333	NM_001005404
YPEL2	hsa-miR-6513-5p	84.9104	NM_001005404
YPEL2	hsa-miR-623	84.8793	NM_001005404
YPEL2	hsa-miR-4773	84.5844	NM_001005404
YPEL2	hsa-miR-29b-2-5p	83.8854	NM_001005404
YPEL2	hsa-miR-133b	83.0537	NM_001005404
YPEL2	hsa-miR-133a-3p	83.0537	NM_001005404
YPEL2	hsa-miR-4500	82.8583	NM_001005404
YPEL2	hsa-miR-12129	82.1043	NM_001005404
YPEL2	hsa-miR-10396a-3p	81.8392	NM_001005404
YPEL2	hsa-miR-10396b-3p	81.8392	NM_001005404

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Motifs and transcription factors (TFs) regulating YPEL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YPEL2	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
YPEL2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
YPEL2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
YPEL2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
YPEL2	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
YPEL2	transfac_pro__M12686	ZBTB10 (directAnnotation).
YPEL2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
YPEL2	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
YPEL2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
YPEL2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
YPEL2	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
YPEL2	transfac_pro__M04617	ZBTB7A (directAnnotation).
YPEL2	metacluster_151.2	ZNF23 (directAnnotation).
YPEL2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
YPEL2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
YPEL2	cisbp__M01864	EGR1 (inferredBy_Orthology).
YPEL2	tfdimers__MD00391	KLF4 (directAnnotation).
YPEL2	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
YPEL2	tfdimers__MD00151	CHURC1 (directAnnotation).
YPEL2	transfac_pro__M04817	ZBTB33 (directAnnotation).
YPEL2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
YPEL2	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
YPEL2	metacluster_3.10	KLF2; KLF4 (directAnnotation).
YPEL2	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
YPEL2	transfac_pro__M01253	CNOT3 (directAnnotation).
YPEL2	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
YPEL2	cisbp__M00968	MTF2 (directAnnotation).
YPEL2	tfdimers__MD00038	TFAP2C (directAnnotation).
YPEL2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
YPEL2	transfac_pro__M01199	TRIM28 (directAnnotation).
YPEL2	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
YPEL2	metacluster_3.14	WT1; WT1 (directAnnotation).
YPEL2	transfac_pro__M12697	ZNF142 (directAnnotation).
YPEL2	transfac_pro__M01122	ZNF219 (directAnnotation).
YPEL2	transfac_pro__M07387	ZBTB7A (directAnnotation).
YPEL2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
YPEL2	transfac_pro__M04893	TAF1 (directAnnotation).
YPEL2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
YPEL2	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
YPEL2	kznf__EGR2_Barrera2016.3_PBM	EGR2 (directAnnotation).
YPEL2	transfac_pro__M00986	CHURC1 (directAnnotation).
YPEL2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
YPEL2	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
YPEL2	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
YPEL2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
YPEL2	transfac_public__M00373	PAX4 (directAnnotation).
YPEL2	cisbp__M00135	ZBTB7B (inferredBy_Orthology).
YPEL2	tfdimers__MD00366	MTF1; OVOL2 (directAnnotation).
YPEL2	transfac_pro__M00938	E2F1 (directAnnotation).
YPEL2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."