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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: YME1L1

Summary for YME1L1

Gene information	Gene symbol	YME1L1
	Ensembl ID	ENSG00000136758
	Entrez ID	10730
	Gene name	YME1 like 1 ATPase
	Synonyms	YME1L
	Gene type	protein_coding
	UniProtAcc	Q96TA2

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Dataset with differentially expressed gene: YME1L1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.50641	1.46e-20
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.302246	2.22e-28
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.30953	2.42e-11
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.271287	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.326398	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.466005	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.349219	4.76e-42
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.276022	1.40e-45
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.291494	1.09e-13
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.393032	0.00e+00

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Expression of YME1L1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to YME1L1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating YME1L1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YME1L1	hsa-miR-590-3p	99.3765	NM_001253866
YME1L1	hsa-miR-4775	98.9009	NM_014263
YME1L1	hsa-miR-4495	97.6754	NM_014263
YME1L1	hsa-miR-4504	96.0681	NM_001253866
YME1L1	hsa-miR-5582-5p	96.0418	NM_001253866
YME1L1	hsa-miR-506-3p	95.9342	NM_001253866
YME1L1	hsa-miR-124-3p	95.9342	NM_001253866
YME1L1	hsa-miR-3935	92.5459	NM_014263
YME1L1	hsa-miR-4501	91.5903	NM_001253866
YME1L1	hsa-miR-3171	91.1522	NM_014263
YME1L1	hsa-miR-3126-5p	90.926	NM_014263
YME1L1	hsa-miR-6875-5p	90.926	NM_014263
YME1L1	hsa-miR-8061	90.7552	NM_014263
YME1L1	hsa-miR-4666b	90.0999	NM_014263
YME1L1	hsa-miR-1305	89.5037	NM_014263
YME1L1	hsa-miR-619-5p	89.4643	NM_014263
YME1L1	hsa-miR-548an	89.3884	NM_001253866
YME1L1	hsa-miR-5585-5p	89.311	NM_001253866
YME1L1	hsa-miR-4684-5p	87.7621	NM_014263
YME1L1	hsa-miR-6509-3p	87.7215	NM_014263
YME1L1	hsa-miR-6506-5p	87.3155	NM_014263
YME1L1	hsa-miR-542-3p	86.9584	NM_001253866
YME1L1	hsa-miR-4760-5p	86.8866	NM_014263
YME1L1	hsa-miR-323b-3p	86.7144	NM_001253866
YME1L1	hsa-miR-7112-5p	85.9112	NM_014263
YME1L1	hsa-miR-374a-5p	84.1509	NM_014263
YME1L1	hsa-miR-6738-3p	83.919	NM_014263
YME1L1	hsa-miR-3662	83.909	NM_014263
YME1L1	hsa-miR-3924	83.8632	NM_014263
YME1L1	hsa-miR-6502-3p	83.7332	NM_001253866
YME1L1	hsa-miR-1243	82.063	NM_014263
YME1L1	hsa-miR-10395-3p	81.5869	NM_014263
YME1L1	hsa-miR-875-5p	81.1387	NM_014263
YME1L1	hsa-miR-374b-5p	80.9491	NM_014263

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Motifs and transcription factors (TFs) regulating YME1L1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YME1L1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
YME1L1	jaspar__MA1483.2	ELF2 (directAnnotation).
YME1L1	hdpi__ETV4	ETV4 (directAnnotation).
YME1L1	transfac_pro__M04826	EP300 (directAnnotation).
YME1L1	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
YME1L1	hdpi__TIMELESS	TIMELESS (directAnnotation).
YME1L1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
YME1L1	hdpi__ELF2	ELF2 (directAnnotation).
YME1L1	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
YME1L1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
YME1L1	metacluster_191.5	SPDEF (inferredBy_Orthology).
YME1L1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."