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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: YIPF4

Summary for YIPF4

Gene information	Gene symbol	YIPF4
	Ensembl ID	ENSG00000119820
	Entrez ID	84272
	Gene name	Yip1 domain family member 4
	Synonyms	FinGER4\|MGC11061
	Gene type	protein_coding
	UniProtAcc	Q9BSR8

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Dataset with differentially expressed gene: YIPF4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.337783	4.51e-25
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.276265	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.292624	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.265322	6.47e-17
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.631679	8.41e-45
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.867685	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.539854	0.00e+00

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Expression of YIPF4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to YIPF4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating YIPF4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YIPF4	hsa-miR-1277-5p	98.8271	NM_032312
YIPF4	hsa-miR-3140-3p	98.2242	NM_032312
YIPF4	hsa-miR-8485	98.1721	NM_032312
YIPF4	hsa-miR-3926	97.591	NM_032312
YIPF4	hsa-miR-138-1-3p	97.5077	NM_032312
YIPF4	hsa-miR-548aj-3p	97.0828	NM_032312
YIPF4	hsa-miR-548x-3p	97.0828	NM_032312
YIPF4	hsa-miR-5011-5p	96.8239	NM_032312
YIPF4	hsa-miR-4325	96.6416	NM_032312
YIPF4	hsa-miR-548ae-3p	96.5443	NM_032312
YIPF4	hsa-miR-548aq-3p	96.5443	NM_032312
YIPF4	hsa-miR-548s	96.0507	NM_032312
YIPF4	hsa-miR-548ah-3p	95.9028	NM_032312
YIPF4	hsa-miR-548j-3p	95.9028	NM_032312
YIPF4	hsa-miR-548am-3p	95.9028	NM_032312
YIPF4	hsa-miR-1244	94.8255	NM_032312
YIPF4	hsa-miR-96-5p	94.4034	NM_032312
YIPF4	hsa-miR-1255b-2-3p	93.905	NM_032312
YIPF4	hsa-miR-12133	93.8781	NM_032312
YIPF4	hsa-miR-1271-5p	93.8781	NM_032312
YIPF4	hsa-miR-4711-5p	93.8507	NM_032312
YIPF4	hsa-miR-7703	92.3887	NM_032312
YIPF4	hsa-miR-12132	92.2737	NM_032312
YIPF4	hsa-miR-6772-3p	91.8146	NM_032312
YIPF4	hsa-miR-568	91.7749	NM_032312
YIPF4	hsa-miR-6128	91.0195	NM_032312
YIPF4	hsa-miR-548c-3p	89.4911	NM_032312
YIPF4	hsa-miR-2115-3p	89.4663	NM_032312
YIPF4	hsa-miR-889-3p	89.0852	NM_032312
YIPF4	hsa-miR-92a-3p	88.9838	NM_032312
YIPF4	hsa-miR-25-3p	88.9838	NM_032312
YIPF4	hsa-miR-32-5p	88.9838	NM_032312
YIPF4	hsa-miR-367-3p	88.9838	NM_032312
YIPF4	hsa-miR-363-3p	88.9838	NM_032312
YIPF4	hsa-miR-92b-3p	88.9838	NM_032312
YIPF4	hsa-miR-653-3p	88.1591	NM_032312
YIPF4	hsa-miR-125b-2-3p	87.7817	NM_032312
YIPF4	hsa-miR-1537-5p	87.4871	NM_032312
YIPF4	hsa-miR-6801-5p	87.4233	NM_032312
YIPF4	hsa-miR-10393-3p	87.4233	NM_032312
YIPF4	hsa-miR-190a-3p	86.8987	NM_032312
YIPF4	hsa-miR-3613-3p	86.0984	NM_032312
YIPF4	hsa-miR-6793-3p	86.0213	NM_032312
YIPF4	hsa-miR-3924	85.8886	NM_032312
YIPF4	hsa-miR-493-5p	85.6478	NM_032312
YIPF4	hsa-miR-6715a-3p	85.6435	NM_032312
YIPF4	hsa-miR-374a-3p	85.3949	NM_032312
YIPF4	hsa-miR-4666a-3p	85.067	NM_032312
YIPF4	hsa-miR-4256	84.5055	NM_032312
YIPF4	hsa-miR-11181-5p	84.5055	NM_032312

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Motifs and transcription factors (TFs) regulating YIPF4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YIPF4	metacluster_7.13	ZFX (directAnnotation).
YIPF4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
YIPF4	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
YIPF4	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
YIPF4	transfac_pro__M06035	ZNF749 (directAnnotation).
YIPF4	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
YIPF4	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
YIPF4	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
YIPF4	metacluster_52.11	ZNF184 (directAnnotation).
YIPF4	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
YIPF4	jaspar__MA1483.2	ELF2 (directAnnotation).
YIPF4	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
YIPF4	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
YIPF4	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
YIPF4	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
YIPF4	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
YIPF4	swissregulon__hs__ELF2	ELF2 (directAnnotation).
YIPF4	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
YIPF4	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
YIPF4	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
YIPF4	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
YIPF4	transfac_pro__M04826	EP300 (directAnnotation).
YIPF4	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
YIPF4	transfac_pro__M04944	GABPA (directAnnotation).
YIPF4	hdpi__FLI1	FLI1 (directAnnotation).
YIPF4	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
YIPF4	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
YIPF4	hdpi__ETV4	ETV4 (directAnnotation).
YIPF4	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
YIPF4	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
YIPF4	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
YIPF4	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
YIPF4	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
YIPF4	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
YIPF4	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
YIPF4	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
YIPF4	transfac_public__M00373	PAX4 (directAnnotation).
YIPF4	metacluster_135.11	NR2C2 (directAnnotation).
YIPF4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
YIPF4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
YIPF4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
YIPF4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
YIPF4	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
YIPF4	jaspar__MA0502.2	NFYB (directAnnotation).
YIPF4	cisbp__M01863	ZNF711 (inferredBy_Orthology).
YIPF4	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."