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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: YES1

Summary for YES1

Gene information	Gene symbol	YES1
	Ensembl ID	ENSG00000176105
	Entrez ID	7525
	Gene name	YES proto-oncogene 1, Src family tyrosine kinase
	Synonyms	c-yes\|HsT441\|Yes
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: YES1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.503753	1.62e-29
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.510457	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.417301	1.56e-24

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Expression of YES1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to YES1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
YES1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating YES1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YES1	hsa-miR-2110	99.4632	NM_005433
YES1	hsa-miR-6512-5p	98.7633	NM_005433
YES1	hsa-miR-133b	96.1562	NM_005433
YES1	hsa-miR-133a-3p	96.1562	NM_005433
YES1	hsa-miR-892c-5p	95.8824	NM_005433
YES1	hsa-miR-2113	95.7692	NM_005433
YES1	hsa-miR-580-3p	95.484	NM_005433
YES1	hsa-miR-4668-5p	95.4403	NM_005433
YES1	hsa-miR-450a-2-3p	95.3124	NM_005433
YES1	hsa-miR-548az-5p	94.3261	NM_005433
YES1	hsa-miR-12123	93.9515	NM_005433
YES1	hsa-miR-548t-5p	93.4939	NM_005433
YES1	hsa-miR-6828-3p	93.055	NM_005433
YES1	hsa-miR-938	93.0418	NM_005433
YES1	hsa-miR-4724-3p	93.0123	NM_005433
YES1	hsa-miR-150-3p	92.1825	NM_005433
YES1	hsa-miR-4760-5p	91.5129	NM_005433
YES1	hsa-miR-5696	90.9568	NM_005433
YES1	hsa-miR-8061	90.2721	NM_005433
YES1	hsa-miR-129-2-3p	90.2575	NM_005433
YES1	hsa-miR-129-1-3p	90.2575	NM_005433
YES1	hsa-miR-548aj-3p	90.0083	NM_005433
YES1	hsa-miR-548x-3p	90.0083	NM_005433
YES1	hsa-miR-4659b-3p	89.6002	NM_005433
YES1	hsa-miR-4659a-3p	89.6002	NM_005433
YES1	hsa-miR-548c-3p	89.204	NM_005433
YES1	hsa-miR-548am-3p	89.0225	NM_005433
YES1	hsa-miR-548ah-3p	89.0225	NM_005433
YES1	hsa-miR-548j-3p	89.0225	NM_005433
YES1	hsa-miR-548aq-3p	89.0225	NM_005433
YES1	hsa-miR-548ae-3p	89.0225	NM_005433
YES1	hsa-miR-5195-3p	88.5707	NM_005433
YES1	hsa-miR-145-5p	88.5707	NM_005433
YES1	hsa-miR-182-5p	88.4466	NM_005433
YES1	hsa-miR-630	87.6702	NM_005433
YES1	hsa-miR-125b-2-3p	87.4584	NM_005433
YES1	hsa-miR-548f-5p	87.0677	NM_005433
YES1	hsa-miR-548g-5p	87.0677	NM_005433
YES1	hsa-miR-548x-5p	87.0677	NM_005433
YES1	hsa-miR-548aj-5p	87.0677	NM_005433
YES1	hsa-miR-122b-5p	87.03	NM_005433
YES1	hsa-miR-4328	87.0037	NM_005433
YES1	hsa-miR-4775	86.9381	NM_005433
YES1	hsa-miR-648	86.8487	NM_005433
YES1	hsa-miR-624-5p	86.5721	NM_005433
YES1	hsa-miR-217-3p	86.5506	NM_005433
YES1	hsa-miR-7849-3p	86.4862	NM_005433
YES1	hsa-miR-5692a	86.425	NM_005433
YES1	hsa-miR-584-3p	86.0394	NM_005433
YES1	hsa-miR-340-5p	85.9995	NM_005433

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Motifs and transcription factors (TFs) regulating YES1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YES1	metacluster_135.11	NR2C2 (directAnnotation).
YES1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
YES1	tfdimers__MD00038	TFAP2C (directAnnotation).
YES1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
YES1	metacluster_7.13	ZFX (directAnnotation).
YES1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
YES1	cisbp__M00968	MTF2 (directAnnotation).
YES1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
YES1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
YES1	cisbp__M00341	PAX6 (directAnnotation).
YES1	metacluster_198.3	ZFP64 (directAnnotation).
YES1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
YES1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
YES1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
YES1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
YES1	cisbp__M00788	ZFY (inferredBy_Orthology).
YES1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
YES1	metacluster_175.1	ZNF283 (directAnnotation).
YES1	hdpi__ZNF304	ZNF304 (directAnnotation).
YES1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
YES1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
YES1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
YES1	transfac_pro__M01199	TRIM28 (directAnnotation).
YES1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
YES1	metacluster_151.2	ZNF23 (directAnnotation).
YES1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
YES1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
YES1	transfac_pro__M03806	ZBTB7C (directAnnotation).
YES1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
YES1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
YES1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
YES1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
YES1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
YES1	jaspar__MA1483.2	ELF2 (directAnnotation).
YES1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
YES1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
YES1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
YES1	cisbp__M02645	ETS1 (directAnnotation).
YES1	hdpi__ETV4	ETV4 (directAnnotation).
YES1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
YES1	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
YES1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
YES1	cisbp__M08198	ELF1 (directAnnotation).
YES1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
YES1	jaspar__MA1708.1	ETV7 (directAnnotation).
YES1	transfac_pro__M04794	TAF1 (directAnnotation).
YES1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
YES1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
YES1	transfac_pro__M04862	NRF1 (directAnnotation).
YES1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
YES1	"Dasatinib"	DB01254	small molecule
YES1	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."