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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: YAP1

Summary for YAP1

Gene information	Gene symbol	YAP1
	Ensembl ID	ENSG00000137693
	Entrez ID	10413
	Gene name	Yes1 associated transcriptional regulator
	Synonyms	YAP-1\|YAP65
	Gene type	protein_coding
	UniProtAcc	P46937

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Dataset with differentially expressed gene: YAP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.303744	4.47e-12
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.583567	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.250563	1.85e-13

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Expression of YAP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to YAP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
YAP1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating YAP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YAP1	hsa-miR-5011-5p	99.902	NM_001130145
YAP1	hsa-miR-190a-3p	98.3099	NM_001130145
YAP1	hsa-miR-548f-5p	96.8404	NM_001130145
YAP1	hsa-miR-548aj-5p	96.8404	NM_001130145
YAP1	hsa-miR-548x-5p	96.8404	NM_001130145
YAP1	hsa-miR-548g-5p	96.8404	NM_001130145
YAP1	hsa-miR-1277-5p	96.4263	NM_001130145
YAP1	hsa-miR-520e-5p	95.1974	NM_001130145
YAP1	hsa-miR-34a-3p	94.9331	NM_001130145
YAP1	hsa-miR-411-3p	94.7732	NM_001130145
YAP1	hsa-miR-379-3p	94.7732	NM_001130145
YAP1	hsa-miR-21-5p	94.4042	NM_001130145
YAP1	hsa-miR-590-5p	94.0742	NM_001130145
YAP1	hsa-miR-889-3p	92.953	NM_001282097
YAP1	hsa-miR-548p	92.3865	NM_001130145
YAP1	hsa-miR-3130-5p	92.2603	NM_001130145
YAP1	hsa-miR-570-3p	91.788	NM_001130145
YAP1	hsa-miR-6071	91.5982	NM_001130145
YAP1	hsa-miR-4780	91.4516	NM_001130145
YAP1	hsa-miR-4482-5p	90.2609	NM_001130145
YAP1	hsa-miR-205-5p	90.0641	NM_001130145
YAP1	hsa-miR-3617-3p	89.2938	NM_001130145
YAP1	hsa-miR-6515-3p	88.2504	NM_001130145
YAP1	hsa-miR-3529-3p	88.1389	NM_001282097
YAP1	hsa-miR-200a-3p	87.5815	NM_001130145
YAP1	hsa-miR-141-3p	87.5815	NM_001130145
YAP1	hsa-miR-1285-3p	87.1081	NM_001282097
YAP1	hsa-miR-509-3p	86.0928	NM_001282097
YAP1	hsa-miR-4293	86.086	NM_001130145
YAP1	hsa-miR-548e-5p	85.9894	NM_001282097
YAP1	hsa-miR-3688-5p	85.2409	NM_001130145
YAP1	hsa-miR-3662	84.9905	NM_001282097
YAP1	hsa-miR-3163	84.2308	NM_001130145
YAP1	hsa-miR-4310	83.1792	NM_001282097
YAP1	hsa-miR-5189-5p	83.1653	NM_001282097
YAP1	hsa-miR-3187-5p	83.1653	NM_001282097
YAP1	hsa-miR-6860	83.1653	NM_001282097
YAP1	hsa-miR-612	83.1653	NM_001282097
YAP1	hsa-miR-6738-3p	82.9751	NM_001130145
YAP1	hsa-miR-548m	82.9241	NM_001282097
YAP1	hsa-miR-429	82.3457	NM_001282097
YAP1	hsa-miR-1236-3p	82.2943	NM_001130145
YAP1	hsa-miR-648	81.7234	NM_001282097
YAP1	hsa-miR-520f-5p	81.6823	NM_001130145
YAP1	hsa-miR-12136	81.4243	NM_001282097
YAP1	hsa-miR-4477b	81.3021	NM_001282097
YAP1	hsa-miR-622	81.104	NM_001130145
YAP1	hsa-miR-340-5p	80.3129	NM_001130145
YAP1	hsa-miR-7157-5p	80.2484	NM_001282097
YAP1	hsa-miR-194-5p	80.1647	NM_001130145

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Motifs and transcription factors (TFs) regulating YAP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YAP1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
YAP1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
YAP1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
YAP1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
YAP1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
YAP1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
YAP1	transfac_pro__M00652	NRF1 (directAnnotation).
YAP1	hdpi__ETV4	ETV4 (directAnnotation).
YAP1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
YAP1	transfac_pro__M04866	HDAC2 (directAnnotation).
YAP1	jaspar__MA1122.1	TFDP1 (directAnnotation).
YAP1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
YAP1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
YAP1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
YAP1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
YAP1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
YAP1	metacluster_7.13	ZFX (directAnnotation).
YAP1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
YAP1	cisbp__M00968	MTF2 (directAnnotation).
YAP1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
YAP1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
YAP1	cisbp__M00341	PAX6 (directAnnotation).
YAP1	metacluster_198.3	ZFP64 (directAnnotation).
YAP1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
YAP1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
YAP1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
YAP1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
YAP1	cisbp__M00788	ZFY (inferredBy_Orthology).
YAP1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
YAP1	metacluster_175.1	ZNF283 (directAnnotation).
YAP1	hdpi__ZNF304	ZNF304 (directAnnotation).
YAP1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
YAP1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
YAP1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
YAP1	transfac_pro__M01199	TRIM28 (directAnnotation).
YAP1	metacluster_151.2	ZNF23 (directAnnotation).
YAP1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
YAP1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
YAP1	transfac_pro__M03806	ZBTB7C (directAnnotation).
YAP1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
YAP1	transfac_pro__M12697	ZNF142 (directAnnotation).
YAP1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
YAP1	jaspar__MA1650.1	ZBTB14 (directAnnotation).
YAP1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
YAP1	tfdimers__MD00483	ZBTB14 (directAnnotation).
YAP1	tfdimers__MD00364	WT1 (directAnnotation).
YAP1	transfac_pro__M04817	ZBTB33 (directAnnotation).
YAP1	transfac_pro__M01253	CNOT3 (directAnnotation).
YAP1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
YAP1	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."