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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: XPNPEP3

Summary for XPNPEP3

Gene information	Gene symbol	XPNPEP3
	Ensembl ID	ENSG00000196236
	Entrez ID	63929
	Gene name	X-prolyl aminopeptidase 3
	Synonyms	APP3\|ICP55\|NPHPL1
	Gene type	protein_coding
	UniProtAcc	Q9NQH7

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Dataset with differentially expressed gene: XPNPEP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.324153	0.00e+00

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Expression of XPNPEP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to XPNPEP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating XPNPEP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
XPNPEP3	hsa-miR-3613-3p	98.0491	NM_022098
XPNPEP3	hsa-miR-616-5p	96.4737	NM_022098
XPNPEP3	hsa-miR-373-5p	96.4737	NM_022098
XPNPEP3	hsa-miR-371b-5p	96.4737	NM_022098
XPNPEP3	hsa-miR-3658	95.6555	NM_022098
XPNPEP3	hsa-miR-9902	95.546	NM_001204827
XPNPEP3	hsa-miR-802	94.4495	NM_022098
XPNPEP3	hsa-miR-183-5p	93.7818	NM_001204827
XPNPEP3	hsa-miR-302b-5p	93.7271	NM_001204827
XPNPEP3	hsa-miR-4261	93.703	NM_022098
XPNPEP3	hsa-miR-1827	93.1808	NM_022098
XPNPEP3	hsa-miR-4768-3p	92.492	NM_022098
XPNPEP3	hsa-miR-302d-5p	91.2723	NM_001204827
XPNPEP3	hsa-miR-6895-3p	91.1739	NM_001204827
XPNPEP3	hsa-miR-147b-5p	91.1725	NM_022098
XPNPEP3	hsa-miR-302c-5p	90.9131	NM_001204827
XPNPEP3	hsa-miR-30d-3p	90.7001	NM_022098
XPNPEP3	hsa-miR-30e-3p	90.7001	NM_022098
XPNPEP3	hsa-miR-30a-3p	90.7001	NM_022098
XPNPEP3	hsa-miR-4441	89.8938	NM_022098
XPNPEP3	hsa-miR-4742-3p	89.5521	NM_022098
XPNPEP3	hsa-miR-92a-3p	89.0144	NM_022098
XPNPEP3	hsa-miR-92b-3p	89.0144	NM_022098
XPNPEP3	hsa-miR-32-5p	89.0144	NM_022098
XPNPEP3	hsa-miR-4803	88.7618	NM_001204827
XPNPEP3	hsa-miR-367-3p	88.4435	NM_022098
XPNPEP3	hsa-miR-363-3p	88.4435	NM_022098
XPNPEP3	hsa-miR-25-3p	88.4435	NM_022098
XPNPEP3	hsa-miR-4478	86.4791	NM_022098
XPNPEP3	hsa-miR-7151-3p	85.6188	NM_022098
XPNPEP3	hsa-miR-6719-3p	85.4661	NM_001204827
XPNPEP3	hsa-miR-4439	84.5692	NM_001204827
XPNPEP3	hsa-miR-3136-5p	84.5692	NM_001204827
XPNPEP3	hsa-miR-194-5p	84.4194	NM_022098
XPNPEP3	hsa-miR-4310	83.9387	NM_022098
XPNPEP3	hsa-miR-4270	83.2533	NM_022098
XPNPEP3	hsa-miR-150-5p	83.102	NM_022098
XPNPEP3	hsa-miR-3689d	82.9933	NM_022098
XPNPEP3	hsa-miR-6851-5p	82.973	NM_022098
XPNPEP3	hsa-miR-544b	82.4039	NM_001204827
XPNPEP3	hsa-miR-133a-5p	81.628	NM_022098
XPNPEP3	hsa-miR-7160-5p	80.7798	NM_022098
XPNPEP3	hsa-miR-6771-3p	80.2421	NM_022098
XPNPEP3	hsa-miR-4728-5p	80.0546	NM_022098

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Motifs and transcription factors (TFs) regulating XPNPEP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."