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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WWP1

Summary for WWP1

Gene information	Gene symbol	WWP1
	Ensembl ID	ENSG00000123124
	Entrez ID	11059
	Gene name	WW domain containing E3 ubiquitin protein ligase 1
	Synonyms	AIP5\|DKFZP434D2111
	Gene type	protein_coding
	UniProtAcc	Q9H0M0

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Dataset with differentially expressed gene: WWP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.400046	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.565056	0.00e+00

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Expression of WWP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WWP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WWP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WWP1	hsa-miR-3973	99.2022	NM_007013
WWP1	hsa-miR-142-5p	96.3853	NM_007013
WWP1	hsa-miR-5590-3p	96.3853	NM_007013
WWP1	hsa-miR-6750-5p	93.569	NM_007013
WWP1	hsa-miR-6822-5p	93.569	NM_007013
WWP1	hsa-miR-448	93.244	NM_007013
WWP1	hsa-miR-190a-3p	92.9076	NM_007013
WWP1	hsa-miR-6889-3p	92.8593	NM_007013
WWP1	hsa-miR-6737-3p	92.8593	NM_007013
WWP1	hsa-miR-7157-3p	92.8593	NM_007013
WWP1	hsa-miR-95-5p	92.0731	NM_007013
WWP1	hsa-miR-3190-3p	91.5981	NM_007013
WWP1	hsa-miR-3680-3p	91.518	NM_007013
WWP1	hsa-miR-5787	91.1262	NM_007013
WWP1	hsa-miR-4505	91.1262	NM_007013
WWP1	hsa-miR-8063	90.6624	NM_007013
WWP1	hsa-miR-4698	90.6624	NM_007013
WWP1	hsa-miR-3977	89.9824	NM_007013
WWP1	hsa-miR-12132	89.679	NM_007013
WWP1	hsa-miR-6529-3p	88.7456	NM_007013
WWP1	hsa-miR-5008-3p	88.7456	NM_007013
WWP1	hsa-miR-507	88.5587	NM_007013
WWP1	hsa-miR-194-5p	87.8724	NM_007013
WWP1	hsa-miR-3121-3p	87.4482	NM_007013
WWP1	hsa-miR-19a-5p	86.2297	NM_007013
WWP1	hsa-miR-19b-2-5p	86.2297	NM_007013
WWP1	hsa-miR-19b-1-5p	86.2297	NM_007013
WWP1	hsa-miR-885-5p	85.813	NM_007013
WWP1	hsa-miR-557	85.6946	NM_007013
WWP1	hsa-miR-30c-5p	85.3848	NM_007013
WWP1	hsa-miR-30e-5p	85.3848	NM_007013
WWP1	hsa-miR-30a-5p	85.3848	NM_007013
WWP1	hsa-miR-30d-5p	85.3848	NM_007013
WWP1	hsa-miR-30b-5p	85.3848	NM_007013
WWP1	hsa-miR-590-5p	84.7726	NM_007013
WWP1	hsa-miR-21-5p	84.7726	NM_007013
WWP1	hsa-miR-7853-5p	84.6412	NM_007013
WWP1	hsa-miR-105-5p	84.6412	NM_007013
WWP1	hsa-miR-4282	84.1129	NM_007013
WWP1	hsa-miR-450b-5p	84.0439	NM_007013
WWP1	hsa-miR-153-3p	84.029	NM_007013
WWP1	hsa-miR-7114-5p	82.9072	NM_007013
WWP1	hsa-miR-559	82.7129	NM_007013
WWP1	hsa-miR-548ac	82.4995	NM_007013
WWP1	hsa-miR-548h-3p	82.4995	NM_007013
WWP1	hsa-miR-548d-3p	82.4995	NM_007013
WWP1	hsa-miR-548z	82.4995	NM_007013
WWP1	hsa-miR-548bb-3p	82.4995	NM_007013
WWP1	hsa-miR-8054	81.843	NM_007013
WWP1	hsa-miR-323a-3p	80.9319	NM_007013

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Motifs and transcription factors (TFs) regulating WWP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WWP1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
WWP1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
WWP1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
WWP1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
WWP1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
WWP1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
WWP1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
WWP1	transfac_pro__M00652	NRF1 (directAnnotation).
WWP1	hdpi__ETV4	ETV4 (directAnnotation).
WWP1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
WWP1	transfac_pro__M04866	HDAC2 (directAnnotation).
WWP1	jaspar__MA1122.1	TFDP1 (directAnnotation).
WWP1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
WWP1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
WWP1	metacluster_135.11	NR2C2 (directAnnotation).
WWP1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
WWP1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
WWP1	metacluster_7.13	ZFX (directAnnotation).
WWP1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
WWP1	cisbp__M00968	MTF2 (directAnnotation).
WWP1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
WWP1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
WWP1	cisbp__M00341	PAX6 (directAnnotation).
WWP1	metacluster_198.3	ZFP64 (directAnnotation).
WWP1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
WWP1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
WWP1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
WWP1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
WWP1	cisbp__M00788	ZFY (inferredBy_Orthology).
WWP1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
WWP1	metacluster_175.1	ZNF283 (directAnnotation).
WWP1	hdpi__ZNF304	ZNF304 (directAnnotation).
WWP1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
WWP1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
WWP1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
WWP1	transfac_pro__M01199	TRIM28 (directAnnotation).
WWP1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
WWP1	metacluster_151.2	ZNF23 (directAnnotation).
WWP1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
WWP1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
WWP1	transfac_pro__M03806	ZBTB7C (directAnnotation).
WWP1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."