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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WNT7B

Summary for WNT7B

Gene information	Gene symbol	WNT7B
	Ensembl ID	ENSG00000188064
	Entrez ID	7477
	Gene name	Wnt family member 7B
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P56706

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Dataset with differentially expressed gene: WNT7B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.866895	0.00e+00

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Expression of WNT7B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WNT7B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
WNT7B	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating WNT7B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WNT7B	hsa-miR-6757-5p	92.0959	NM_058238
WNT7B	hsa-miR-5187-5p	88.4703	NM_058238
WNT7B	hsa-miR-4803	87.2945	NM_058238
WNT7B	hsa-miR-6506-5p	86.5185	NM_058238
WNT7B	hsa-miR-619-5p	86.4602	NM_058238
WNT7B	hsa-miR-4314	84.0727	NM_058238
WNT7B	hsa-miR-1207-5p	82.3717	NM_058238
WNT7B	hsa-miR-330-5p	82.2615	NM_058238
WNT7B	hsa-miR-6127	82.1557	NM_058238
WNT7B	hsa-miR-196a-1-3p	81.4996	NM_058238
WNT7B	hsa-miR-4763-3p	81.4778	NM_058238
WNT7B	hsa-miR-570-3p	81.0981	NM_058238
WNT7B	hsa-miR-4525	80.2574	NM_058238
WNT7B	hsa-miR-5010-5p	80.2574	NM_058238

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Motifs and transcription factors (TFs) regulating WNT7B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WNT7B	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
WNT7B	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
WNT7B	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."