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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WIZ

Summary for WIZ

Gene information	Gene symbol	WIZ
	Ensembl ID	ENSG00000011451
	Entrez ID	58525
	Gene name	WIZ zinc finger
	Synonyms	ZNF803
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: WIZ

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.286049	3.74e-28
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.40447	0.00e+00

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Expression of WIZ in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WIZ

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WIZ

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WIZ	hsa-miR-6867-5p	99.1598	NM_021241
WIZ	hsa-miR-4723-5p	98.9215	NM_021241
WIZ	hsa-miR-6870-5p	98.9215	NM_021241
WIZ	hsa-miR-7111-5p	98.9215	NM_021241
WIZ	hsa-miR-5698	98.9215	NM_021241
WIZ	hsa-miR-132-5p	96.6147	NM_021241
WIZ	hsa-miR-1275	93.1471	NM_021241
WIZ	hsa-miR-7108-5p	92.0524	NM_021241
WIZ	hsa-miR-548aw	91.462	NM_021241
WIZ	hsa-miR-874-5p	90.3257	NM_021241
WIZ	hsa-miR-1468-3p	89.6807	NM_021241
WIZ	hsa-miR-4437	89.2639	NM_021241
WIZ	hsa-miR-3180-5p	88.2801	NM_021241
WIZ	hsa-miR-12136	87.5215	NM_021241
WIZ	hsa-miR-10398-5p	86.9818	NM_021241
WIZ	hsa-miR-4684-5p	86.6128	NM_021241
WIZ	hsa-miR-6772-3p	86.4812	NM_021241
WIZ	hsa-miR-6873-5p	85.3842	NM_021241
WIZ	hsa-miR-520b-5p	84.3797	NM_021241
WIZ	hsa-miR-519a-2-5p	84.3797	NM_021241
WIZ	hsa-miR-328-5p	84.2229	NM_021241
WIZ	hsa-miR-6885-5p	84.2229	NM_021241
WIZ	hsa-miR-4665-5p	83.6983	NM_021241
WIZ	hsa-miR-625-5p	82.2714	NM_021241
WIZ	hsa-miR-5572	81.8004	NM_021241
WIZ	hsa-miR-4296	80.4618	NM_021241

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Motifs and transcription factors (TFs) regulating WIZ

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WIZ	hdpi__FLI1	FLI1 (directAnnotation).
WIZ	jaspar__MA1708.1	ETV7 (directAnnotation).
WIZ	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."