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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WIPI1

Summary for WIPI1

Gene information	Gene symbol	WIPI1
	Ensembl ID	ENSG00000070540
	Entrez ID	55062
	Gene name	WD repeat domain, phosphoinositide interacting 1
	Synonyms	ATG18\|ATG18A\|FLJ10055\|WIPI49
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: WIPI1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.12563	4.47e-05
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.281256	1.70e-13
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.292998	1.28e-06
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.789607	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-1.52176	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.36438	0.00e+00

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Expression of WIPI1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WIPI1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WIPI1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WIPI1	hsa-miR-300	96.916	NM_001320772
WIPI1	hsa-miR-381-3p	96.916	NM_001320772
WIPI1	hsa-miR-380-3p	94.6008	NM_017983
WIPI1	hsa-miR-4659b-5p	93.4089	NM_017983
WIPI1	hsa-miR-7110-3p	91.8534	NM_017983
WIPI1	hsa-miR-4659a-5p	91.2731	NM_017983
WIPI1	hsa-miR-3163	89.3903	NM_001320772
WIPI1	hsa-miR-4666a-3p	89.316	NM_001320772
WIPI1	hsa-miR-4795-3p	86.9978	NM_001320772
WIPI1	hsa-let-7f-1-3p	86.1616	NM_001320772
WIPI1	hsa-let-7a-3p	86.1616	NM_001320772
WIPI1	hsa-miR-98-3p	86.1616	NM_001320772
WIPI1	hsa-let-7b-3p	86.1616	NM_001320772
WIPI1	hsa-miR-1277-5p	85.9665	NM_001320772
WIPI1	hsa-miR-6776-3p	85.1382	NM_001320772
WIPI1	hsa-miR-7162-3p	82.9588	NM_017983
WIPI1	hsa-miR-4710	80.3651	NM_017983

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Motifs and transcription factors (TFs) regulating WIPI1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WIPI1	metacluster_7.13	ZFX (directAnnotation).
WIPI1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
WIPI1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
WIPI1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
WIPI1	transfac_pro__M05479	ZNF580 (directAnnotation).
WIPI1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
WIPI1	jaspar__MA0079.5	SP1 (directAnnotation).
WIPI1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
WIPI1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
WIPI1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
WIPI1	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
WIPI1	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
WIPI1	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
WIPI1	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
WIPI1	metacluster_52.11	ZNF184 (directAnnotation).
WIPI1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
WIPI1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
WIPI1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
WIPI1	transfac_pro__M07387	ZBTB7A (directAnnotation).
WIPI1	transfac_pro__M03876	ZBTB33 (directAnnotation).
WIPI1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
WIPI1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
WIPI1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
WIPI1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
WIPI1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
WIPI1	transfac_pro__M05804	ZBTB41 (inferredBy_Orthology).
WIPI1	transfac_pro__M05513	ZNF641 (inferredBy_Orthology).
WIPI1	jaspar__MA0502.2	NFYB (directAnnotation).
WIPI1	jaspar__MA1562.1	SOX14 (directAnnotation).
WIPI1	transfac_pro__M06601	ZNF501 (directAnnotation).
WIPI1	metacluster_14.23	TFE3 (directAnnotation).
WIPI1	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."