Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WIPF2

Summary for WIPF2

Gene information	Gene symbol	WIPF2
	Ensembl ID	ENSG00000171475
	Entrez ID	147179
	Gene name	WAS/WASL interacting protein family member 2
	Synonyms	WICH\|WIRE
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: WIPF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.252017	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.267355	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.26035	2.17e-12
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.580383	0.00e+00

Top

Expression of WIPF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to WIPF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating WIPF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WIPF2	hsa-miR-3714	96.8279	NM_133264
WIPF2	hsa-miR-657	94.8702	NM_133264
WIPF2	hsa-miR-122b-5p	94.6856	NM_133264
WIPF2	hsa-miR-4768-3p	93.2423	NM_133264
WIPF2	hsa-miR-4708-5p	91.4569	NM_133264
WIPF2	hsa-miR-124-3p	91.2401	NM_133264
WIPF2	hsa-miR-506-3p	91.2401	NM_133264
WIPF2	hsa-miR-1253	90.974	NM_133264
WIPF2	hsa-miR-4772-5p	90.2872	NM_133264
WIPF2	hsa-miR-605-3p	89.1571	NM_133264
WIPF2	hsa-miR-3665	88.6155	NM_133264
WIPF2	hsa-miR-6839-3p	88.2325	NM_133264
WIPF2	hsa-miR-6126	88.1658	NM_133264
WIPF2	hsa-miR-153-3p	87.9789	NM_133264
WIPF2	hsa-miR-525-5p	87.6535	NM_133264
WIPF2	hsa-miR-515-5p	87.2563	NM_133264
WIPF2	hsa-miR-519e-5p	87.2563	NM_133264
WIPF2	hsa-miR-4294	87.1724	NM_133264
WIPF2	hsa-miR-6511a-5p	87.1407	NM_133264
WIPF2	hsa-miR-1910-3p	87.0228	NM_133264
WIPF2	hsa-miR-6759-3p	87.01	NM_133264
WIPF2	hsa-miR-608	86.8964	NM_133264
WIPF2	hsa-miR-4651	86.8964	NM_133264
WIPF2	hsa-miR-6765-3p	86.7627	NM_133264
WIPF2	hsa-miR-27a-3p	86.577	NM_133264
WIPF2	hsa-miR-27b-3p	86.577	NM_133264
WIPF2	hsa-miR-3611	86.384	NM_133264
WIPF2	hsa-miR-3168	86.2643	NM_133264
WIPF2	hsa-miR-6770-5p	86.2119	NM_133264
WIPF2	hsa-miR-520a-5p	84.806	NM_133264
WIPF2	hsa-miR-6798-3p	84.7019	NM_133264
WIPF2	hsa-miR-924	84.6571	NM_133264
WIPF2	hsa-miR-4290	84.502	NM_133264
WIPF2	hsa-miR-206	83.7369	NM_133264
WIPF2	hsa-miR-1-3p	83.7369	NM_133264
WIPF2	hsa-miR-4251	83.5859	NM_133264
WIPF2	hsa-miR-766-5p	83.5318	NM_133264
WIPF2	hsa-miR-9985	83.3074	NM_133264
WIPF2	hsa-miR-10522-5p	82.7038	NM_133264
WIPF2	hsa-miR-4531	82.5867	NM_133264
WIPF2	hsa-miR-6867-5p	82.2768	NM_133264
WIPF2	hsa-miR-4476	82.259	NM_133264
WIPF2	hsa-miR-6876-5p	82.259	NM_133264
WIPF2	hsa-miR-613	82.1639	NM_133264
WIPF2	hsa-miR-1236-3p	81.4206	NM_133264
WIPF2	hsa-miR-2355-5p	80.6425	NM_133264

Page: 1

Top

Motifs and transcription factors (TFs) regulating WIPF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WIPF2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
WIPF2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
WIPF2	transfac_pro__M07397	ZNF148 (directAnnotation).
WIPF2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
WIPF2	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
WIPF2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
WIPF2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
WIPF2	transfac_pro__M01175	ZBTB7B (directAnnotation).
WIPF2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
WIPF2	tfdimers__MD00151	CHURC1 (directAnnotation).
WIPF2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
WIPF2	transfac_pro__M01303	SP1 (directAnnotation).
WIPF2	transfac_pro__M01714	KLF15 (directAnnotation).
WIPF2	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
WIPF2	metacluster_3.14	WT1; WT1 (directAnnotation).
WIPF2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
WIPF2	transfac_pro__M07436	WT1 (directAnnotation).
WIPF2	transfac_pro__M02281	SP1 (directAnnotation).
WIPF2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
WIPF2	transfac_public__M00491	PATZ1 (directAnnotation).
WIPF2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
WIPF2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
WIPF2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
WIPF2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
WIPF2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
WIPF2	transfac_pro__M01973	PLAG1 (directAnnotation).
WIPF2	metacluster_143.13	ZBTB7A (directAnnotation).
WIPF2	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
WIPF2	jaspar__MA0079.5	SP1 (directAnnotation).
WIPF2	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."