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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WDR82

Summary for WDR82

Gene information	Gene symbol	WDR82
	Ensembl ID	ENSG00000164091
	Entrez ID	80335
	Gene name	WD repeat domain 82
	Synonyms	MST107\|MSTP107\|PRO2730\|PRO34047\|SWD2\|TMEM113\|WDR82A
	Gene type	protein_coding
	UniProtAcc	Q6UXN9

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Dataset with differentially expressed gene: WDR82

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.32203	8.28e-24
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.346612	1.66e-25

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Expression of WDR82 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WDR82

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WDR82

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WDR82	hsa-miR-4470	98.9211	NM_025222
WDR82	hsa-miR-22-3p	96.305	NM_025222
WDR82	hsa-miR-4493	96.2031	NM_025222
WDR82	hsa-miR-33a-3p	95.593	NM_025222
WDR82	hsa-miR-30c-5p	94.8631	NM_025222
WDR82	hsa-miR-30d-5p	94.8631	NM_025222
WDR82	hsa-miR-30b-5p	94.8631	NM_025222
WDR82	hsa-miR-30e-5p	94.8631	NM_025222
WDR82	hsa-miR-30a-5p	94.8631	NM_025222
WDR82	hsa-miR-509-5p	94.0554	NM_025222
WDR82	hsa-miR-509-3-5p	94.0554	NM_025222
WDR82	hsa-miR-4262	93.8983	NM_025222
WDR82	hsa-miR-181c-5p	93.3022	NM_025222
WDR82	hsa-miR-181d-5p	93.3022	NM_025222
WDR82	hsa-miR-181a-5p	93.3022	NM_025222
WDR82	hsa-miR-181b-5p	93.3022	NM_025222
WDR82	hsa-miR-3148	91.8833	NM_025222
WDR82	hsa-miR-429	91.1262	NM_025222
WDR82	hsa-miR-200c-3p	91.1262	NM_025222
WDR82	hsa-miR-200b-3p	91.1262	NM_025222
WDR82	hsa-miR-4418	90.7308	NM_025222
WDR82	hsa-miR-1185-2-3p	90.5537	NM_025222
WDR82	hsa-miR-1185-1-3p	90.5537	NM_025222
WDR82	hsa-let-7f-2-3p	90.0492	NM_025222
WDR82	hsa-miR-12133	90.0437	NM_025222
WDR82	hsa-miR-1271-5p	90.0437	NM_025222
WDR82	hsa-miR-96-5p	89.1046	NM_025222
WDR82	hsa-miR-6768-5p	88.2686	NM_025222
WDR82	hsa-miR-4747-5p	88.0835	NM_025222
WDR82	hsa-miR-5196-5p	88.0835	NM_025222
WDR82	hsa-miR-654-5p	87.4611	NM_025222
WDR82	hsa-miR-541-3p	87.4611	NM_025222
WDR82	hsa-miR-766-3p	87.4085	NM_025222
WDR82	hsa-miR-193b-3p	87.2385	NM_025222
WDR82	hsa-miR-193a-3p	87.2385	NM_025222
WDR82	hsa-miR-3163	84.9849	NM_025222
WDR82	hsa-miR-224-5p	84.9484	NM_025222
WDR82	hsa-miR-3686	84.8179	NM_025222
WDR82	hsa-miR-6760-3p	84.5689	NM_025222
WDR82	hsa-miR-6499-3p	83.9871	NM_025222
WDR82	hsa-miR-8055	83.6937	NM_025222
WDR82	hsa-miR-122b-3p	82.8538	NM_025222
WDR82	hsa-miR-21-3p	82.8538	NM_025222
WDR82	hsa-miR-8485	82.6532	NM_025222
WDR82	hsa-miR-4802-3p	82.6499	NM_025222
WDR82	hsa-miR-4301	82.6484	NM_025222
WDR82	hsa-miR-1237-3p	82.0434	NM_025222
WDR82	hsa-miR-4495	81.5342	NM_025222
WDR82	hsa-miR-8069	80.9716	NM_025222
WDR82	hsa-miR-29b-2-5p	80.7374	NM_025222

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Motifs and transcription factors (TFs) regulating WDR82

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WDR82	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
WDR82	cisbp__M00968	MTF2 (directAnnotation).
WDR82	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
WDR82	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
WDR82	metacluster_175.1	ZNF283 (directAnnotation).
WDR82	hdpi__ZNF304	ZNF304 (directAnnotation).
WDR82	transfac_pro__M01199	TRIM28 (directAnnotation).
WDR82	metacluster_151.2	ZNF23 (directAnnotation).
WDR82	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
WDR82	metacluster_7.13	ZFX (directAnnotation).
WDR82	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
WDR82	cisbp__M01863	ZNF711 (inferredBy_Orthology).
WDR82	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
WDR82	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."