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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WDR76

Summary for WDR76

Gene information	Gene symbol	WDR76
	Ensembl ID	ENSG00000092470
	Entrez ID	79968
	Gene name	WD repeat domain 76
	Synonyms	FLJ12973
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: WDR76

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.2111	2.69e-04
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.294995	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.305449	1.00e-23

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Expression of WDR76 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WDR76

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WDR76

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WDR76	hsa-miR-5011-5p	99.647	NM_001167941
WDR76	hsa-miR-6508-5p	98.1507	NM_001167941
WDR76	hsa-miR-8067	98.0336	NM_001167941
WDR76	hsa-miR-190a-3p	97.1285	NM_001167941
WDR76	hsa-miR-6830-5p	92.9718	NM_001167941
WDR76	hsa-miR-302f	92.9378	NM_001167941
WDR76	hsa-miR-211-5p	91.6885	NM_001167941
WDR76	hsa-miR-204-5p	91.6885	NM_001167941
WDR76	hsa-miR-7-1-3p	91.5811	NM_001167941
WDR76	hsa-miR-7-2-3p	91.5811	NM_001167941
WDR76	hsa-miR-330-3p	90.3845	NM_001167941
WDR76	hsa-miR-561-5p	88.5938	NM_001167941
WDR76	hsa-miR-182-5p	88.3114	NM_001167941
WDR76	hsa-miR-5680	86.6883	NM_001167941
WDR76	hsa-miR-199b-5p	86.4367	NM_001167941
WDR76	hsa-miR-199a-5p	86.4367	NM_001167941
WDR76	hsa-miR-34c-3p	86.1732	NM_001167941
WDR76	hsa-miR-3613-3p	86.1295	NM_001167941
WDR76	hsa-miR-3124-3p	83.8515	NM_001167941
WDR76	hsa-miR-373-5p	83.8218	NM_001167941
WDR76	hsa-miR-616-5p	83.8218	NM_001167941
WDR76	hsa-miR-371b-5p	83.8218	NM_001167941
WDR76	hsa-miR-625-3p	83.8056	NM_001167941
WDR76	hsa-miR-3059-5p	82.5713	NM_001167941
WDR76	hsa-miR-664a-3p	81.8812	NM_001167941
WDR76	hsa-miR-6882-5p	80.2795	NM_001167941
WDR76	hsa-miR-1827	80.1341	NM_001167941

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Motifs and transcription factors (TFs) regulating WDR76

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WDR76	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
WDR76	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
WDR76	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
WDR76	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
WDR76	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
WDR76	metacluster_55.5	ZNF541 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."