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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WDR45B

Summary for WDR45B

Gene information	Gene symbol	WDR45B
	Ensembl ID	ENSG00000141580
	Entrez ID	56270
	Gene name	WD repeat domain 45B
	Synonyms	WDR45L\|WIPI3
	Gene type	protein_coding
	UniProtAcc	Q5MNZ6

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Dataset with differentially expressed gene: WDR45B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.302427	4.71e-11
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.434171	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.516201	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.268198	6.17e-44
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.456438	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.316861	1.55e-09
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.292614	1.57e-08
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.746065	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.770909	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.266353	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.405077	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.322752	0.00e+00

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Expression of WDR45B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WDR45B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WDR45B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WDR45B	hsa-miR-6873-3p	95.7564	NM_019613
WDR45B	hsa-miR-4645-3p	95.0978	NM_019613
WDR45B	hsa-miR-19a-3p	93.8042	NM_019613
WDR45B	hsa-miR-19b-3p	93.8042	NM_019613
WDR45B	hsa-miR-548aw	92.7975	NM_019613
WDR45B	hsa-miR-3529-3p	92.7024	NM_019613
WDR45B	hsa-miR-3065-5p	90.877	NM_019613
WDR45B	hsa-miR-648	90.5995	NM_019613
WDR45B	hsa-miR-4511	88.4414	NM_019613
WDR45B	hsa-miR-642b-5p	88.0879	NM_019613
WDR45B	hsa-miR-6734-3p	88.0421	NM_019613
WDR45B	hsa-miR-548aj-5p	87.2324	NM_019613
WDR45B	hsa-miR-548x-5p	87.2324	NM_019613
WDR45B	hsa-miR-548g-5p	87.2324	NM_019613
WDR45B	hsa-miR-548f-5p	87.2324	NM_019613
WDR45B	hsa-miR-3133	86.3593	NM_019613
WDR45B	hsa-miR-4643	86.1876	NM_019613
WDR45B	hsa-miR-1468-3p	85.6941	NM_019613
WDR45B	hsa-miR-323a-3p	84.1078	NM_019613
WDR45B	hsa-miR-12120	82.0007	NM_019613

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Motifs and transcription factors (TFs) regulating WDR45B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WDR45B	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
WDR45B	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
WDR45B	transfac_pro__M02843	BBX (inferredBy_Orthology).
WDR45B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
WDR45B	cisbp__M00249	WT1 (directAnnotation).
WDR45B	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
WDR45B	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
WDR45B	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
WDR45B	transfac_pro__M12697	ZNF142 (directAnnotation).
WDR45B	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
WDR45B	metacluster_143.13	ZBTB7A (directAnnotation).
WDR45B	swissregulon__hs__ELF2	ELF2 (directAnnotation).
WDR45B	jaspar__MA1933.1	SREBF2 (directAnnotation).
WDR45B	swissregulon__hs__ETV6	ETV6 (directAnnotation).
WDR45B	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
WDR45B	transfac_pro__M05976	ZNF223 (directAnnotation).
WDR45B	transfac_pro__M06249	ZNF616 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."