Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WDR43

Summary for WDR43

Gene information	Gene symbol	WDR43
	Ensembl ID	ENSG00000163811
	Entrez ID	23160
	Gene name	WD repeat domain 43
	Synonyms	KIAA0007\|NET12\|UTP5
	Gene type	protein_coding
	UniProtAcc	Q15061

Top

Dataset with differentially expressed gene: WDR43

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.735501	1.00e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.293974	2.00e-14
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.381199	7.25e-17
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.264488	3.92e-07
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.392334	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.345141	2.86e-20
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.344515	6.51e-13
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.276128	1.10e-08
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.370706	8.33e-15
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.342554	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.432474	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.431793	0.00e+00

Top

Expression of WDR43 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to WDR43

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating WDR43

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WDR43	hsa-miR-548c-3p	98.557	NM_015131
WDR43	hsa-miR-340-5p	96.2857	NM_015131
WDR43	hsa-miR-656-3p	94.5312	NM_015131
WDR43	hsa-miR-4469	93.9498	NM_015131
WDR43	hsa-miR-892a	93.0968	NM_015131
WDR43	hsa-miR-3148	93.0526	NM_015131
WDR43	hsa-miR-646	92.772	NM_015131
WDR43	hsa-miR-4672	91.8885	NM_015131
WDR43	hsa-miR-6890-3p	91.2063	NM_015131
WDR43	hsa-miR-889-3p	90.9343	NM_015131
WDR43	hsa-miR-548ap-3p	89.4242	NM_015131
WDR43	hsa-miR-548t-3p	89.4242	NM_015131
WDR43	hsa-miR-548aa	89.4242	NM_015131
WDR43	hsa-miR-561-3p	89.0918	NM_015131
WDR43	hsa-miR-6739-5p	88.6785	NM_015131
WDR43	hsa-miR-6733-5p	88.6785	NM_015131
WDR43	hsa-miR-640	87.54	NM_015131
WDR43	hsa-miR-524-5p	87.2133	NM_015131
WDR43	hsa-miR-520d-5p	87.2133	NM_015131
WDR43	hsa-miR-3143	87.0502	NM_015131
WDR43	hsa-miR-12123	86.6478	NM_015131
WDR43	hsa-miR-4743-3p	86.6237	NM_015131
WDR43	hsa-miR-4311	86.2869	NM_015131
WDR43	hsa-miR-3163	86.2776	NM_015131
WDR43	hsa-miR-149-5p	86.098	NM_015131
WDR43	hsa-miR-513a-5p	85.6613	NM_015131
WDR43	hsa-miR-4324	85.3574	NM_015131
WDR43	hsa-miR-382-3p	84.5472	NM_015131
WDR43	hsa-miR-4668-5p	83.5458	NM_015131
WDR43	hsa-miR-3153	83.4706	NM_015131
WDR43	hsa-miR-223-3p	83.1318	NM_015131
WDR43	hsa-miR-4697-3p	83.1318	NM_015131
WDR43	hsa-miR-5590-5p	82.5988	NM_015131
WDR43	hsa-miR-215-3p	81.5804	NM_015131
WDR43	hsa-miR-508-5p	81.4398	NM_015131
WDR43	hsa-miR-4790-3p	80.237	NM_015131

Page: 1

Top

Motifs and transcription factors (TFs) regulating WDR43

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WDR43	metacluster_7.13	ZFX (directAnnotation).
WDR43	cisbp__M01863	ZNF711 (inferredBy_Orthology).
WDR43	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
WDR43	metacluster_151.2	ZNF23 (directAnnotation).
WDR43	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
WDR43	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
WDR43	metacluster_182.10	ZFX (directAnnotation).
WDR43	hdpi__ETV4	ETV4 (directAnnotation).
WDR43	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
WDR43	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
WDR43	swissregulon__hs__ETV6	ETV6 (directAnnotation).
WDR43	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
WDR43	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
WDR43	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
WDR43	jaspar__MA0748.2	YY2 (directAnnotation).
WDR43	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
WDR43	cisbp__M00788	ZFY (inferredBy_Orthology).
WDR43	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
WDR43	hdpi__TIMELESS	TIMELESS (directAnnotation).
WDR43	metacluster_191.5	SPDEF (inferredBy_Orthology).
WDR43	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
WDR43	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
WDR43	transfac_pro__M02913	SP140 (inferredBy_Orthology).
WDR43	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
WDR43	hocomoco__ZFX_MOUSE.H11MO.1.B	ZFY (inferredBy_Orthology).
WDR43	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
WDR43	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
WDR43	hdpi__ELF2	ELF2 (directAnnotation).
WDR43	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
WDR43	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
WDR43	swissregulon__hs__ELK1	ELK1 (directAnnotation).
WDR43	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
WDR43	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
WDR43	metacluster_81.7	CREB1 (directAnnotation).
WDR43	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
WDR43	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
WDR43	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
WDR43	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
WDR43	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
WDR43	transfac_pro__M04950	EGR1 (directAnnotation).
WDR43	transfac_pro__M04886	ETS1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."