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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: WDHD1

Summary for WDHD1

Gene informationGene symbol

WDHD1

Ensembl ID

ENSG00000198554

Entrez ID

11169

Gene nameWD repeat and HMG-box DNA binding protein 1
SynonymsAND-1|CHTF4|CTF4
Gene typeprotein_coding
UniProtAcc

O75717


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Dataset with differentially expressed gene: WDHD1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells-0.9913912.62e-04

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells-0.4091568.92e-19

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Expression of WDHD1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to WDHD1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WDHD1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
WDHD1hsa-miR-5011-5p99.3646NM_007086
WDHD1hsa-miR-316398.8742NM_001008396
WDHD1hsa-miR-190a-3p95.3033NM_007086
WDHD1hsa-miR-875-3p94.9939NM_007086
WDHD1hsa-miR-5699-3p93.7962NM_007086
WDHD1hsa-miR-1213192.967NM_007086
WDHD1hsa-miR-442192.5481NM_007086
WDHD1hsa-miR-505-3p92.1169NM_007086
WDHD1hsa-miR-126-5p91.2281NM_007086
WDHD1hsa-miR-314889.8748NM_007086
WDHD1hsa-miR-4666a-5p86.9296NM_007086
WDHD1hsa-miR-1277-5p86.3821NM_007086
WDHD1hsa-miR-444386.2492NM_007086
WDHD1hsa-miR-4714-3p85.2742NM_007086
WDHD1hsa-miR-892a85.1253NM_007086
WDHD1hsa-miR-474884.9658NM_007086
WDHD1hsa-miR-446484.9658NM_007086
WDHD1hsa-miR-4665-5p84.3544NM_007086
WDHD1hsa-miR-127584.3544NM_007086
WDHD1hsa-miR-5589-3p84.022NM_007086
WDHD1hsa-miR-3191-5p83.7482NM_007086
WDHD1hsa-miR-442283.3966NM_007086
WDHD1hsa-miR-519d-5p83.1846NM_007086
WDHD1hsa-miR-29a-5p81.8425NM_007086
WDHD1hsa-miR-518c-5p81.6389NM_007086
WDHD1hsa-miR-4777-3p81.4794NM_007086
WDHD1hsa-miR-361-5p81.4121NM_007086
WDHD1hsa-miR-60781.2181NM_007086
WDHD1hsa-miR-453181.204NM_007086
WDHD1hsa-miR-4796-5p80.5614NM_007086
WDHD1hsa-miR-942-5p80.5509NM_007086
WDHD1hsa-miR-472980.2424NM_001008396
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Motifs and transcription factors (TFs) regulating WDHD1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."