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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WASL

Summary for WASL

Gene information	Gene symbol	WASL
	Ensembl ID	ENSG00000106299
	Entrez ID	8976
	Gene name	WASP like actin nucleation promoting factor
	Synonyms	N-WASP\|NWASP\|WASPB
	Gene type	protein_coding
	UniProtAcc	O00401

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Dataset with differentially expressed gene: WASL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.352893	2.52e-07
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.348879	1.29e-16

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Expression of WASL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WASL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WASL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WASL	hsa-miR-190a-3p	99.9595	NM_003941
WASL	hsa-miR-5011-5p	99.9556	NM_003941
WASL	hsa-miR-3658	99.5879	NM_003941
WASL	hsa-miR-4282	96.4616	NM_003941
WASL	hsa-miR-543	96.3012	NM_003941
WASL	hsa-miR-142-3p	94.4775	NM_003941
WASL	hsa-miR-186-5p	94.328	NM_003941
WASL	hsa-miR-3120-3p	93.9199	NM_003941
WASL	hsa-miR-182-5p	93.8865	NM_003941
WASL	hsa-miR-590-3p	93.2609	NM_003941
WASL	hsa-miR-1468-3p	92.7113	NM_003941
WASL	hsa-miR-4775	92.0359	NM_003941
WASL	hsa-miR-449b-3p	91.7711	NM_003941
WASL	hsa-miR-10395-3p	91.0742	NM_003941
WASL	hsa-miR-6073	89.528	NM_003941
WASL	hsa-miR-4732-5p	88.1311	NM_003941
WASL	hsa-miR-10395-5p	87.636	NM_003941
WASL	hsa-miR-92a-3p	87.4298	NM_003941
WASL	hsa-miR-92b-3p	87.4298	NM_003941
WASL	hsa-miR-32-5p	87.4298	NM_003941
WASL	hsa-miR-12132	87.4172	NM_003941
WASL	hsa-miR-367-3p	87.1904	NM_003941
WASL	hsa-miR-363-3p	87.1904	NM_003941
WASL	hsa-miR-25-3p	87.1904	NM_003941
WASL	hsa-miR-4666a-5p	87.1879	NM_003941
WASL	hsa-miR-7702	86.5165	NM_003941
WASL	hsa-miR-3613-3p	86.1119	NM_003941
WASL	hsa-miR-7856-5p	85.0804	NM_003941
WASL	hsa-miR-4514	84.3384	NM_003941
WASL	hsa-miR-4692	84.3384	NM_003941
WASL	hsa-miR-4659a-3p	83.7073	NM_003941
WASL	hsa-miR-4659b-3p	83.7073	NM_003941
WASL	hsa-miR-1324	83.5095	NM_003941
WASL	hsa-miR-4720-5p	83.4238	NM_003941
WASL	hsa-miR-5588-5p	83.4238	NM_003941
WASL	hsa-miR-4799-3p	83.4238	NM_003941
WASL	hsa-miR-1277-5p	83.3311	NM_003941
WASL	hsa-miR-139-5p	82.7786	NM_003941
WASL	hsa-miR-622	82.524	NM_003941
WASL	hsa-miR-3646	82.3382	NM_003941
WASL	hsa-miR-3143	82.257	NM_003941
WASL	hsa-miR-8062	82.2094	NM_003941
WASL	hsa-miR-4262	81.8094	NM_003941
WASL	hsa-miR-1207-3p	81.3901	NM_003941
WASL	hsa-miR-3130-3p	81.3857	NM_003941
WASL	hsa-miR-196a-3p	80.8215	NM_003941

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Motifs and transcription factors (TFs) regulating WASL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WASL	metacluster_135.11	NR2C2 (directAnnotation).
WASL	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
WASL	tfdimers__MD00038	TFAP2C (directAnnotation).
WASL	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
WASL	metacluster_7.13	ZFX (directAnnotation).
WASL	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
WASL	cisbp__M00968	MTF2 (directAnnotation).
WASL	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
WASL	metacluster_160.20	JUND; PRDM15 (directAnnotation).
WASL	cisbp__M00341	PAX6 (directAnnotation).
WASL	metacluster_198.3	ZFP64 (directAnnotation).
WASL	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
WASL	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
WASL	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
WASL	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
WASL	cisbp__M00788	ZFY (inferredBy_Orthology).
WASL	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
WASL	metacluster_175.1	ZNF283 (directAnnotation).
WASL	hdpi__ZNF304	ZNF304 (directAnnotation).
WASL	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
WASL	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
WASL	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
WASL	transfac_pro__M01199	TRIM28 (directAnnotation).
WASL	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
WASL	metacluster_151.2	ZNF23 (directAnnotation).
WASL	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
WASL	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
WASL	transfac_pro__M03806	ZBTB7C (directAnnotation).
WASL	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
WASL	transfac_pro__M12697	ZNF142 (directAnnotation).
WASL	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
WASL	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
WASL	jaspar__MA1650.1	ZBTB14 (directAnnotation).
WASL	transfac_pro__M02089	E2F3 (directAnnotation).
WASL	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
WASL	transfac_pro__M00322	MAX; MYC (directAnnotation).
WASL	tfdimers__MD00483	ZBTB14 (directAnnotation).
WASL	transfac_pro__M06085	ZNF26 (directAnnotation).
WASL	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
WASL	tfdimers__MD00364	WT1 (directAnnotation).
WASL	transfac_pro__M04817	ZBTB33 (directAnnotation).
WASL	transfac_public__M00114	CREB1 (directAnnotation).
WASL	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
WASL	transfac_pro__M01253	CNOT3 (directAnnotation).
WASL	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
WASL	metacluster_175.5	IRX3; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP63; TP63; TP63; TP63; TP63; TP63; TP73; TP73; TP73; TP73; TP73; TP73 (directAnnotation). TP53; TP53; TP53; TP73 (inferredBy_Orthology).
WASL	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."