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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WASF2

Summary for WASF2

Gene information	Gene symbol	WASF2
	Ensembl ID	ENSG00000158195
	Entrez ID	10163
	Gene name	WASP family member 2
	Synonyms	SCAR2\|WAVE2
	Gene type	protein_coding
	UniProtAcc	Q9Y6W5

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Dataset with differentially expressed gene: WASF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.367717	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.492852	1.63e-34
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.261516	1.50e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.477382	1.71e-15
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	0.296102	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.05409	1.81e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.307603	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	Malignant cells	-0.321546	2.33e-16
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.379224	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.428663	0.00e+00

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Expression of WASF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WASF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WASF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WASF2	hsa-miR-4436b-3p	98.2497	NM_001201404
WASF2	hsa-miR-6828-5p	97.7265	NM_001201404
WASF2	hsa-miR-6735-5p	97.313	NM_001201404
WASF2	hsa-miR-7843-5p	97.313	NM_001201404
WASF2	hsa-miR-4632-5p	97.313	NM_001201404
WASF2	hsa-miR-6879-5p	97.313	NM_001201404
WASF2	hsa-miR-4642	95.8449	NM_001201404
WASF2	hsa-miR-1827	95.7049	NM_001201404
WASF2	hsa-miR-9-5p	95.438	NM_001201404
WASF2	hsa-miR-4721	92.3818	NM_001201404
WASF2	hsa-miR-4692	91.9768	NM_001201404
WASF2	hsa-miR-4736	91.3972	NM_001201404
WASF2	hsa-miR-4514	91.0063	NM_001201404
WASF2	hsa-miR-4476	90.8072	NM_006990
WASF2	hsa-miR-6876-5p	90.8072	NM_006990
WASF2	hsa-miR-4695-5p	90.7541	NM_006990
WASF2	hsa-miR-133b	88.9762	NM_001201404
WASF2	hsa-miR-133a-3p	88.9762	NM_001201404
WASF2	hsa-miR-12119	88.6236	NM_001201404
WASF2	hsa-miR-647	87.8667	NM_006990
WASF2	hsa-miR-2467-3p	87.5559	NM_001201404
WASF2	hsa-miR-506-3p	87.3869	NM_001201404
WASF2	hsa-miR-124-3p	87.3869	NM_001201404
WASF2	hsa-miR-650	87.3279	NM_006990
WASF2	hsa-miR-3612	87.3279	NM_006990
WASF2	hsa-miR-655-3p	86.7253	NM_001201404
WASF2	hsa-miR-374c-5p	86.7253	NM_001201404
WASF2	hsa-miR-1910-3p	86.698	NM_001201404
WASF2	hsa-miR-10226	85.8333	NM_006990
WASF2	hsa-miR-1253	85.3308	NM_006990
WASF2	hsa-miR-3158-3p	85.2715	NM_001201404
WASF2	hsa-miR-6511a-5p	85.1188	NM_001201404
WASF2	hsa-miR-1252-5p	83.6991	NM_006990
WASF2	hsa-miR-2110	83.6258	NM_006990
WASF2	hsa-miR-486-3p	83.5609	NM_006990
WASF2	hsa-miR-6875-5p	83.2527	NM_001201404
WASF2	hsa-miR-3126-5p	83.2527	NM_001201404
WASF2	hsa-miR-887-5p	83.1834	NM_006990
WASF2	hsa-miR-6762-3p	82.9226	NM_006990
WASF2	hsa-miR-10526-3p	82.811	NM_001201404
WASF2	hsa-miR-5582-5p	81.1105	NM_001201404
WASF2	hsa-miR-2861	80.9458	NM_006990
WASF2	hsa-miR-4739	80.0975	NM_006990

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Motifs and transcription factors (TFs) regulating WASF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WASF2	metacluster_7.13	ZFX (directAnnotation).
WASF2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
WASF2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
WASF2	metacluster_151.2	ZNF23 (directAnnotation).
WASF2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
WASF2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
WASF2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
WASF2	transfac_pro__M05628	ZNF735 (directAnnotation).
WASF2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
WASF2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
WASF2	jaspar__MA0079.5	SP1 (directAnnotation).
WASF2	transfac_pro__M07397	ZNF148 (directAnnotation).
WASF2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
WASF2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
WASF2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
WASF2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
WASF2	tfdimers__MD00151	CHURC1 (directAnnotation).
WASF2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
WASF2	transfac_pro__M01303	SP1 (directAnnotation).
WASF2	transfac_pro__M01714	KLF15 (directAnnotation).
WASF2	transfac_pro__M02089	E2F3 (directAnnotation).
WASF2	metacluster_3.14	WT1; WT1 (directAnnotation).
WASF2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
WASF2	cisbp__M07938	E2F1 (directAnnotation).
WASF2	transfac_pro__M02281	SP1 (directAnnotation).
WASF2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
WASF2	transfac_pro__M02898	SMAD3 (directAnnotation).
WASF2	transfac_public__M00491	PATZ1 (directAnnotation).
WASF2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
WASF2	transfac_pro__M01783	SP2 (directAnnotation).
WASF2	transfac_pro__M04817	ZBTB33 (directAnnotation).
WASF2	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
WASF2	jaspar__MA0748.2	YY2 (directAnnotation).
WASF2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
WASF2	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
WASF2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
WASF2	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
WASF2	jaspar__MA1708.1	ETV7 (directAnnotation).
WASF2	cisbp__M00249	WT1 (directAnnotation).
WASF2	transfac_pro__M01122	ZNF219 (directAnnotation).
WASF2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
WASF2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
WASF2	metacluster_3.10	KLF2; KLF4 (directAnnotation).
WASF2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
WASF2	jaspar__MA1122.1	TFDP1 (directAnnotation).
WASF2	transfac_pro__M01199	TRIM28 (directAnnotation).
WASF2	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
WASF2	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
WASF2	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
WASF2	transfac_pro__M12697	ZNF142 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."