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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VTA1

Summary for VTA1

Gene information	Gene symbol	VTA1
	Ensembl ID	ENSG00000009844
	Entrez ID	51534
	Gene name	vesicle trafficking 1
	Synonyms	C6orf55\|HSPC228\|My012
	Gene type	protein_coding
	UniProtAcc	Q9NP79

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Dataset with differentially expressed gene: VTA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.29482	1.43e-15
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.366442	6.26e-34
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.284807	1.08e-43

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Expression of VTA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VTA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VTA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VTA1	hsa-miR-1911-3p	96.9233	NM_016485
VTA1	hsa-miR-4673	95.2447	NM_016485
VTA1	hsa-miR-4533	95.1838	NM_016485
VTA1	hsa-miR-5688	94.0385	NM_016485
VTA1	hsa-miR-4645-5p	93.6512	NM_016485
VTA1	hsa-miR-495-3p	93.5146	NM_016485
VTA1	hsa-miR-4478	93.356	NM_016485
VTA1	hsa-miR-3929	93.356	NM_016485
VTA1	hsa-miR-6835-3p	90.4243	NM_016485
VTA1	hsa-miR-590-3p	89.9845	NM_016485
VTA1	hsa-miR-3646	89.6473	NM_016485
VTA1	hsa-miR-6749-3p	89.3502	NM_016485
VTA1	hsa-miR-576-5p	88.8357	NM_016485
VTA1	hsa-miR-8076	88.7059	NM_016485
VTA1	hsa-miR-628-3p	87.495	NM_016485
VTA1	hsa-miR-4477a	86.8768	NM_001286371
VTA1	hsa-miR-1276	85.8769	NM_016485
VTA1	hsa-miR-6832-3p	84.5841	NM_016485
VTA1	hsa-miR-3977	83.9726	NM_016485
VTA1	hsa-miR-629-3p	83.8439	NM_016485
VTA1	hsa-miR-335-3p	82.0509	NM_001286371
VTA1	hsa-miR-5584-5p	81.9723	NM_016485
VTA1	hsa-miR-498-3p	81.9044	NM_001286371
VTA1	hsa-miR-153-5p	81.8884	NM_001286371
VTA1	hsa-miR-4803	81.2503	NM_016485
VTA1	hsa-miR-183-3p	80.6732	NM_016485

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Motifs and transcription factors (TFs) regulating VTA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VTA1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
VTA1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
VTA1	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
VTA1	hdpi__FLI1	FLI1 (directAnnotation).
VTA1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
VTA1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."