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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VSTM2L

Summary for VSTM2L

Gene information	Gene symbol	VSTM2L
	Ensembl ID	ENSG00000132821
	Entrez ID	128434
	Gene name	V-set and transmembrane domain containing 2 like
	Synonyms	C20orf102\|dJ1118M15.2
	Gene type	protein_coding
	UniProtAcc	Q96N03

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Dataset with differentially expressed gene: VSTM2L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	1.46072	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	1.28924	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	1.77734	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.575975	2.04e-34
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.718922	0.00e+00

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Expression of VSTM2L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VSTM2L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VSTM2L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VSTM2L	hsa-miR-138-5p	98.3021	NM_080607
VSTM2L	hsa-miR-506-5p	96.1175	NM_080607
VSTM2L	hsa-miR-4663	88.5506	NM_080607
VSTM2L	hsa-miR-767-3p	86.6139	NM_080607
VSTM2L	hsa-miR-6798-5p	86.2465	NM_080607
VSTM2L	hsa-miR-3180	85.0264	NM_080607
VSTM2L	hsa-miR-3180-3p	85.0264	NM_080607
VSTM2L	hsa-miR-6816-5p	85.0264	NM_080607
VSTM2L	hsa-miR-3196	82.5897	NM_080607
VSTM2L	hsa-miR-328-5p	82.5783	NM_080607
VSTM2L	hsa-miR-6842-3p	81.9048	NM_080607
VSTM2L	hsa-miR-608	81.2292	NM_080607
VSTM2L	hsa-miR-4651	81.2292	NM_080607

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Motifs and transcription factors (TFs) regulating VSTM2L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VSTM2L	transfac_pro__M03813	POU3F3 (directAnnotation).
VSTM2L	tfdimers__MD00339	HMGA1; HMGA2; TFAP2C (directAnnotation).
VSTM2L	transfac_pro__M06602	ZNF669 (directAnnotation).
VSTM2L	metacluster_110.2	ZNF549 (directAnnotation).
VSTM2L	metacluster_150.9	VSX2; VSX2 (directAnnotation).
VSTM2L	metacluster_74.6	HNF1A (directAnnotation).
VSTM2L	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_CAP	HOXB13; ONECUT2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."