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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VSIG4

Summary for VSIG4

Gene information	Gene symbol	VSIG4
	Ensembl ID	ENSG00000155659
	Entrez ID	11326
	Gene name	V-set and immunoglobulin domain containing 4
	Synonyms	CRIg\|Z39IG
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: VSIG4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.428107	6.37e-17
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.54138	1.48e-38
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.48517	6.35e-35
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.480112	4.07e-03

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Expression of VSIG4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VSIG4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VSIG4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VSIG4	hsa-miR-589-3p	86.4374	NM_001257403
VSIG4	hsa-miR-6510-5p	85.2346	NM_001184831
VSIG4	hsa-miR-1291	83.2754	NM_001257403
VSIG4	hsa-miR-4456	81.6125	NM_001257403
VSIG4	hsa-miR-6775-3p	80.722	NM_001257403

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Motifs and transcription factors (TFs) regulating VSIG4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VSIG4	metacluster_168.13	ZNF287; ZNF324; ZNF324B (directAnnotation). ZNF287 (inferredBy_Orthology).
VSIG4	cisbp__M00262	ARX (directAnnotation).
VSIG4	homer__TWGTCTGV_Smad3	SMAD3 (inferredBy_Orthology).
VSIG4	transfac_pro__M06795	ZNF780B (directAnnotation).
VSIG4	transfac_pro__M06131	ZNF10 (directAnnotation).
VSIG4	jaspar__MA0035.4	GATA1 (directAnnotation).
VSIG4	transfac_pro__M05842	ZBTB41 (inferredBy_Orthology).
VSIG4	tfdimers__MD00186	NFATC3; SPI1 (directAnnotation).
VSIG4	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
VSIG4	metacluster_147.3	MGA; MGA; TBX1; TBX15; TBX15; TBX18; TBX19; TBX20; TBX20; TBX20; TBX21; TBX22; ZNF18; ZNF18; ZNF18; ZNF18 (directAnnotation). MGA; TBX21 (inferredBy_Orthology).
VSIG4	homer__ATTAACACCT_Eomes	EOMES (directAnnotation).
VSIG4	taipale_tf_pairs__ALX4_TBX21_RGGTGYTAATWR_CAP	ALX4; TBX21 (directAnnotation).
VSIG4	kznf__ZNF675_Najafabadi2015_ChIP-seq	ZNF675 (directAnnotation).
VSIG4	transfac_pro__M06007	ZNF69 (directAnnotation).
VSIG4	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
VSIG4	swissregulon__hs__ZNF784	ZNF784 (directAnnotation).
VSIG4	tfdimers__MD00433	NKX3-2; ZNF217 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."