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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VPS4B

Summary for VPS4B

Gene information	Gene symbol	VPS4B
	Ensembl ID	ENSG00000119541
	Entrez ID	9525
	Gene name	vacuolar protein sorting 4 homolog B
	Synonyms	SKD1\|SKD1B\|VPS4-2
	Gene type	protein_coding
	UniProtAcc	O75351

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Dataset with differentially expressed gene: VPS4B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.340719	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.282589	1.95e-31
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.351232	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.251019	4.61e-28
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.576403	0.00e+00

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Expression of VPS4B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VPS4B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VPS4B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VPS4B	hsa-miR-590-3p	96.6059	NM_004869
VPS4B	hsa-miR-186-5p	96.5545	NM_004869
VPS4B	hsa-miR-4319	96.5285	NM_004869
VPS4B	hsa-miR-125b-5p	94.6916	NM_004869
VPS4B	hsa-miR-125a-5p	94.6916	NM_004869
VPS4B	hsa-miR-4795-3p	94.3544	NM_004869
VPS4B	hsa-miR-147b-5p	94.3379	NM_004869
VPS4B	hsa-miR-4775	94.0562	NM_004869
VPS4B	hsa-miR-4261	93.9184	NM_004869
VPS4B	hsa-miR-345-3p	93.6139	NM_004869
VPS4B	hsa-miR-19b-3p	91.3343	NM_004869
VPS4B	hsa-miR-19a-3p	91.3343	NM_004869
VPS4B	hsa-miR-4672	91.3243	NM_004869
VPS4B	hsa-miR-154-5p	90.8108	NM_004869
VPS4B	hsa-miR-3681-3p	90.6557	NM_004869
VPS4B	hsa-miR-128-3p	90.6557	NM_004869
VPS4B	hsa-miR-216a-3p	90.6557	NM_004869
VPS4B	hsa-miR-4659b-3p	90.5424	NM_004869
VPS4B	hsa-miR-4659a-3p	90.5424	NM_004869
VPS4B	hsa-miR-670-5p	90.3984	NM_004869
VPS4B	hsa-miR-4666b	90.2378	NM_004869
VPS4B	hsa-miR-875-3p	87.9829	NM_004869
VPS4B	hsa-miR-6730-5p	87.3264	NM_004869
VPS4B	hsa-miR-548k	87.0769	NM_004869
VPS4B	hsa-miR-548av-5p	87.0769	NM_004869
VPS4B	hsa-miR-8054	87.0769	NM_004869
VPS4B	hsa-miR-3163	85.687	NM_004869
VPS4B	hsa-miR-548x-3p	85.018	NM_004869
VPS4B	hsa-miR-548aj-3p	85.018	NM_004869
VPS4B	hsa-miR-367-3p	84.7698	NM_004869
VPS4B	hsa-miR-92b-3p	84.7698	NM_004869
VPS4B	hsa-miR-363-3p	84.7698	NM_004869
VPS4B	hsa-miR-32-5p	84.7698	NM_004869
VPS4B	hsa-miR-25-3p	84.7698	NM_004869
VPS4B	hsa-miR-92a-3p	84.7698	NM_004869
VPS4B	hsa-miR-548aq-3p	84.5522	NM_004869
VPS4B	hsa-miR-548ae-3p	84.5522	NM_004869
VPS4B	hsa-miR-548j-3p	84.5522	NM_004869
VPS4B	hsa-miR-548ah-3p	84.5522	NM_004869
VPS4B	hsa-miR-548am-3p	84.5522	NM_004869
VPS4B	hsa-miR-6826-5p	84.431	NM_004869
VPS4B	hsa-miR-4539	84.2702	NM_004869
VPS4B	hsa-miR-12113	84.2702	NM_004869
VPS4B	hsa-miR-4760-3p	83.897	NM_004869
VPS4B	hsa-miR-186-3p	83.4242	NM_004869
VPS4B	hsa-miR-7151-3p	82.3975	NM_004869
VPS4B	hsa-miR-6507-5p	81.8841	NM_004869
VPS4B	hsa-miR-3161	81.5354	NM_004869
VPS4B	hsa-miR-5582-5p	80.2574	NM_004869

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Motifs and transcription factors (TFs) regulating VPS4B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VPS4B	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
VPS4B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
VPS4B	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
VPS4B	hdpi__ETV4	ETV4 (directAnnotation).
VPS4B	transfac_pro__M06071	ZNF814 (directAnnotation).
VPS4B	transfac_pro__M04826	EP300 (directAnnotation).
VPS4B	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
VPS4B	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
VPS4B	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
VPS4B	transfac_pro__M02089	E2F3 (directAnnotation).
VPS4B	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
VPS4B	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
VPS4B	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
VPS4B	cisbp__M00788	ZFY (inferredBy_Orthology).
VPS4B	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
VPS4B	hdpi__ZNF304	ZNF304 (directAnnotation).
VPS4B	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
VPS4B	hdpi__HIP2	UBE2K (directAnnotation).
VPS4B	transfac_pro__M02898	SMAD3 (directAnnotation).
VPS4B	metacluster_191.5	SPDEF (inferredBy_Orthology).
VPS4B	hdpi__TIMELESS	TIMELESS (directAnnotation).
VPS4B	transfac_pro__M04893	TAF1 (directAnnotation).
VPS4B	transfac_pro__M00430	E2F1 (directAnnotation).
VPS4B	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
VPS4B	hdpi__TP73	TP73 (directAnnotation).
VPS4B	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
VPS4B	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
VPS4B	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
VPS4B	hdpi__ELF2	ELF2 (directAnnotation).
VPS4B	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."