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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VPS37B

Summary for VPS37B

Gene information	Gene symbol	VPS37B
	Ensembl ID	ENSG00000139722
	Entrez ID	79720
	Gene name	VPS37B subunit of ESCRT-I
	Synonyms	FLJ12750
	Gene type	protein_coding
	UniProtAcc	Q9H9H4

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Dataset with differentially expressed gene: VPS37B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	-0.308771	2.86e-04
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.373715	3.33e-17
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.26809	8.53e-39
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.414195	6.55e-27
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.335198	1.41e-09
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.718887	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.588987	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.263831	2.61e-04
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.30404	3.23e-39
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.283813	1.63e-33
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.420227	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.296069	6.98e-03
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.349332	0.00e+00

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Expression of VPS37B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VPS37B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VPS37B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VPS37B	hsa-miR-3163	91.0685	NM_024667
VPS37B	hsa-miR-4790-3p	86.4526	NM_024667
VPS37B	hsa-miR-670-5p	85.7735	NM_024667
VPS37B	hsa-miR-345-3p	85.3675	NM_024667
VPS37B	hsa-miR-5571-5p	84.2169	NM_024667
VPS37B	hsa-miR-1275	83.9688	NM_024667
VPS37B	hsa-miR-20a-3p	83.9235	NM_024667
VPS37B	hsa-miR-4446-5p	83.917	NM_024667
VPS37B	hsa-miR-4277	83.3382	NM_024667
VPS37B	hsa-miR-4319	83.2597	NM_024667
VPS37B	hsa-miR-5006-3p	81.5361	NM_024667
VPS37B	hsa-miR-4755-5p	81.5361	NM_024667

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Motifs and transcription factors (TFs) regulating VPS37B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VPS37B	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
VPS37B	transfac_pro__M01861	ATF1 (directAnnotation).
VPS37B	metacluster_52.11	ZNF184 (directAnnotation).
VPS37B	metacluster_35.7	HINFP (inferredBy_Orthology).
VPS37B	metacluster_98.1	ZNF524 (directAnnotation).
VPS37B	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
VPS37B	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
VPS37B	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
VPS37B	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
VPS37B	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
VPS37B	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
VPS37B	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
VPS37B	transfac_public__M00039	CREB1 (directAnnotation).
VPS37B	cisbp__M04023	CREB1 (directAnnotation).
VPS37B	transfac_pro__M00691	ATF1 (directAnnotation).
VPS37B	transfac_pro__M04746	E2F1 (directAnnotation).
VPS37B	transfac_pro__M08803	CREM (directAnnotation).
VPS37B	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
VPS37B	tfdimers__MD00031	MYB; ZEB1 (directAnnotation).
VPS37B	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
VPS37B	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
VPS37B	metacluster_173.2	ATF3; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; BATF3; CREB3; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L4; XBP1; XBP1; XBP1; XBP1 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM (inferredBy_Orthology).
VPS37B	transfac_pro__M05804	ZBTB41 (inferredBy_Orthology).
VPS37B	tfdimers__MD00095	ELF1; NEUROD1 (directAnnotation).
VPS37B	jaspar__MA1125.1	ZNF384 (directAnnotation).
VPS37B	hdpi__TIMELESS	TIMELESS (directAnnotation).
VPS37B	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
VPS37B	transfac_pro__M06249	ZNF616 (directAnnotation).
VPS37B	tfdimers__MD00595	SREBF1; SREBF2; TBP (directAnnotation).
VPS37B	cisbp__M00839	FOXP1 (directAnnotation).
VPS37B	metacluster_139.9	TFE3 (inferredBy_Orthology).
VPS37B	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
VPS37B	transfac_pro__M04887	TCF12 (directAnnotation).
VPS37B	metacluster_22.32	NFE2L2 (directAnnotation).
VPS37B	metacluster_111.5	E4F1; E4F1 (directAnnotation).
VPS37B	metacluster_167.7	IRF8 (inferredBy_Orthology).
VPS37B	hdpi__CREB1	CREB1 (directAnnotation).
VPS37B	cisbp__M01816	JUN (inferredBy_Orthology).
VPS37B	taipale_cyt_meth__JUND_NRTGACGCATN_eDBD_repr	JUND (directAnnotation).
VPS37B	metacluster_70.19	POU1F1 (directAnnotation).
VPS37B	transfac_pro__M06557	ZNF418 (directAnnotation).
VPS37B	metacluster_22.28	BACH1 (directAnnotation).
VPS37B	taipale_tf_pairs__ERF_SREBF2_NNCACGTGACMGGAARNN_CAP_repr	ERF; SREBF2 (directAnnotation).
VPS37B	tfdimers__MD00217	LTF; MZF1 (directAnnotation).
VPS37B	transfac_pro__M06857	ZNF611 (directAnnotation).
VPS37B	metacluster_23.5	WT1 (directAnnotation).
VPS37B	transfac_pro__M00805	LEF1; TCF7; TCF7L1 (directAnnotation).
VPS37B	tfdimers__MD00165	CRX; FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND (directAnnotation).
VPS37B	transfac_pro__M06073	ZNF749 (directAnnotation).
VPS37B	transfac_pro__M06486	ZNF610 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."