Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VPS26A

Summary for VPS26A

Gene information	Gene symbol	VPS26A
	Ensembl ID	ENSG00000122958
	Entrez ID	9559
	Gene name	VPS26 retromer complex component A
	Synonyms	Hbeta58\|PEP8A\|VPS26
	Gene type	protein_coding
	UniProtAcc	O75436

Top

Dataset with differentially expressed gene: VPS26A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.301353	2.16e-10
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.316771	9.45e-07
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.261711	1.96e-37
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.344307	1.54e-18

Top

Expression of VPS26A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to VPS26A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating VPS26A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VPS26A	hsa-miR-607	99.1261	NM_001035260
VPS26A	hsa-miR-9983-3p	98.6421	NM_001035260
VPS26A	hsa-miR-4775	98.0164	NM_001318944
VPS26A	hsa-miR-129-5p	97.7272	NM_001035260
VPS26A	hsa-miR-122b-5p	97.6111	NM_001318944
VPS26A	hsa-miR-6832-5p	97.2604	NM_001318944
VPS26A	hsa-miR-520h	96.953	NM_001035260
VPS26A	hsa-miR-520g-3p	96.953	NM_001035260
VPS26A	hsa-miR-3973	95.4413	NM_001035260
VPS26A	hsa-miR-548p	95.0579	NM_001035260
VPS26A	hsa-miR-371b-5p	94.5522	NM_001318944
VPS26A	hsa-miR-616-5p	94.5522	NM_001318944
VPS26A	hsa-miR-373-5p	94.5522	NM_001318944
VPS26A	hsa-miR-3148	94.4947	NM_001318944
VPS26A	hsa-miR-590-3p	93.9184	NM_001318944
VPS26A	hsa-miR-199a-5p	92.0967	NM_001035260
VPS26A	hsa-miR-199b-5p	92.0967	NM_001035260
VPS26A	hsa-miR-3926	91.991	NM_001318944
VPS26A	hsa-miR-150-3p	91.5232	NM_001318944
VPS26A	hsa-miR-6893-3p	91.4605	NM_001318944
VPS26A	hsa-miR-370-3p	91.4605	NM_001318944
VPS26A	hsa-miR-1468-3p	90.5678	NM_001035260
VPS26A	hsa-miR-3688-3p	90.217	NM_001318944
VPS26A	hsa-miR-4666b	89.3987	NM_001318944
VPS26A	hsa-miR-4293	89.255	NM_001318944
VPS26A	hsa-miR-591	88.8581	NM_001318944
VPS26A	hsa-miR-7-2-3p	87.8126	NM_001318944
VPS26A	hsa-miR-7-5p	87.6545	NM_001035260
VPS26A	hsa-miR-550b-3p	87.2863	NM_001035260
VPS26A	hsa-miR-671-5p	86.3906	NM_001318944
VPS26A	hsa-miR-542-3p	86.2565	NM_001318944
VPS26A	hsa-miR-509-3p	85.993	NM_001318944
VPS26A	hsa-miR-3680-3p	85.1274	NM_001035260
VPS26A	hsa-miR-7-1-3p	84.6101	NM_001318944
VPS26A	hsa-miR-1825	84.433	NM_001035260
VPS26A	hsa-miR-5002-5p	84.0238	NM_001035260
VPS26A	hsa-miR-3123	83.309	NM_001318944
VPS26A	hsa-miR-6514-5p	82.5955	NM_001318944
VPS26A	hsa-miR-145-5p	82.3187	NM_001035260
VPS26A	hsa-miR-5195-3p	82.3187	NM_001035260
VPS26A	hsa-miR-504-3p	82.2674	NM_001318944
VPS26A	hsa-miR-138-5p	82.1309	NM_001035260
VPS26A	hsa-miR-4451	81.6356	NM_001318944
VPS26A	hsa-miR-548s	81.4768	NM_001318944
VPS26A	hsa-miR-4528	81.1059	NM_001318944

Page: 1

Top

Motifs and transcription factors (TFs) regulating VPS26A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VPS26A	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
VPS26A	swissregulon__hs__ETV6	ETV6 (directAnnotation).
VPS26A	transfac_pro__M04861	SIX5 (directAnnotation).
VPS26A	transfac_pro__M04826	EP300 (directAnnotation).
VPS26A	metacluster_135.11	NR2C2 (directAnnotation).
VPS26A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
VPS26A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
VPS26A	metacluster_7.13	ZFX (directAnnotation).
VPS26A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
VPS26A	cisbp__M00968	MTF2 (directAnnotation).
VPS26A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
VPS26A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
VPS26A	cisbp__M00341	PAX6 (directAnnotation).
VPS26A	metacluster_198.3	ZFP64 (directAnnotation).
VPS26A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
VPS26A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
VPS26A	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
VPS26A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
VPS26A	cisbp__M00788	ZFY (inferredBy_Orthology).
VPS26A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
VPS26A	metacluster_175.1	ZNF283 (directAnnotation).
VPS26A	hdpi__ZNF304	ZNF304 (directAnnotation).
VPS26A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
VPS26A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
VPS26A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
VPS26A	transfac_pro__M01199	TRIM28 (directAnnotation).
VPS26A	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
VPS26A	metacluster_151.2	ZNF23 (directAnnotation).
VPS26A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
VPS26A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
VPS26A	transfac_pro__M03806	ZBTB7C (directAnnotation).
VPS26A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
VPS26A	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
VPS26A	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
VPS26A	hdpi__ETV4	ETV4 (directAnnotation).
VPS26A	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
VPS26A	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
VPS26A	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
VPS26A	transfac_pro__M04794	TAF1 (directAnnotation).
VPS26A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
VPS26A	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
VPS26A	jaspar__MA0748.2	YY2 (directAnnotation).
VPS26A	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
VPS26A	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
VPS26A	metacluster_182.10	ZFX (directAnnotation).
VPS26A	transfac_pro__M00492	STAT1 (directAnnotation).
VPS26A	metacluster_57.3	ARNT; ATF3; ATF3; ATF3; ATF3; BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; BHLHE41; MITF; MITF; MITF; MLX; MLXIPL; SREBF1; SREBF1; SREBF1; SREBF1; SREBF2; SREBF2; SREBF2; TFE3; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; ZNF507 (directAnnotation). ARNTL; BHLHE40; BHLHE40; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL; MLX; MLX; SREBF1; SREBF2; TFE3; USF1; USF1; USF2; USF2 (inferredBy_Orthology).
VPS26A	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
VPS26A	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
VPS26A	metacluster_172.6	CHD2; E2F1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."