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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VHL

Summary for VHL

Gene information	Gene symbol	VHL
	Ensembl ID	ENSG00000134086
	Entrez ID	7428
	Gene name	von Hippel-Lindau tumor suppressor
	Synonyms	VHL1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: VHL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.446905	0.00e+00

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Expression of VHL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VHL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
VHL	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating VHL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VHL	hsa-miR-371b-5p	96.7515	NM_000551
VHL	hsa-miR-616-5p	96.7515	NM_000551
VHL	hsa-miR-373-5p	96.7515	NM_000551
VHL	hsa-miR-3065-3p	95.1962	NM_000551
VHL	hsa-miR-7151-3p	92.5397	NM_000551
VHL	hsa-miR-3613-3p	89.8752	NM_000551
VHL	hsa-miR-513b-5p	89.2831	NM_000551
VHL	hsa-miR-4755-3p	88.4761	NM_000551
VHL	hsa-miR-383-3p	85.2322	NM_000551
VHL	hsa-miR-504-3p	85.1026	NM_000551
VHL	hsa-miR-767-5p	85.0961	NM_000551
VHL	hsa-miR-340-5p	83.9209	NM_000551
VHL	hsa-miR-155-3p	83.0649	NM_000551
VHL	hsa-miR-4429	82.9484	NM_000551
VHL	hsa-miR-320c	82.9484	NM_000551
VHL	hsa-miR-320a-3p	82.9484	NM_000551
VHL	hsa-miR-320b	82.9484	NM_000551
VHL	hsa-miR-320d	82.9484	NM_000551
VHL	hsa-miR-548ar-3p	82.3532	NM_000551
VHL	hsa-miR-3646	82.3281	NM_000551
VHL	hsa-miR-4639-3p	81.8454	NM_000551
VHL	hsa-miR-4482-3p	81.6481	NM_000551
VHL	hsa-miR-7162-5p	80.8627	NM_000551
VHL	hsa-miR-516b-3p	80.8627	NM_000551
VHL	hsa-miR-516a-3p	80.8627	NM_000551

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Motifs and transcription factors (TFs) regulating VHL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VHL	metacluster_135.11	NR2C2 (directAnnotation).
VHL	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
VHL	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
VHL	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
VHL	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
VHL	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."