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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VEZT

Summary for VEZT

Gene information	Gene symbol	VEZT
	Ensembl ID	ENSG00000028203
	Entrez ID	55591
	Gene name	vezatin, adherens junctions transmembrane protein
	Synonyms	DKFZP761C241
	Gene type	protein_coding
	UniProtAcc	Q9HBM0

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Dataset with differentially expressed gene: VEZT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.632162	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.335851	0.00e+00

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Expression of VEZT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VEZT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VEZT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VEZT	hsa-miR-653-3p	97.2582	NM_017599
VEZT	hsa-miR-606	93.8744	NM_017599
VEZT	hsa-miR-548n	91.4444	NM_017599
VEZT	hsa-miR-888-5p	90.9604	NM_017599
VEZT	hsa-miR-3679-3p	90.3114	NM_017599
VEZT	hsa-miR-4799-5p	89.5232	NM_017599
VEZT	hsa-miR-548ar-3p	87.2697	NM_017599
VEZT	hsa-miR-182-5p	87.1216	NM_017599
VEZT	hsa-miR-4712-3p	87.0026	NM_017599
VEZT	hsa-miR-3671	86.2061	NM_017599
VEZT	hsa-miR-1227-3p	85.5259	NM_017599
VEZT	hsa-miR-5100	85.418	NM_017599
VEZT	hsa-miR-548a-3p	85.0052	NM_017599
VEZT	hsa-miR-4676-3p	83.0524	NM_017599
VEZT	hsa-miR-892c-3p	83.0524	NM_017599
VEZT	hsa-miR-452-5p	83.0524	NM_017599
VEZT	hsa-miR-31-5p	81.9667	NM_017599
VEZT	hsa-miR-12120	81.2094	NM_017599
VEZT	hsa-miR-4494	81.076	NM_017599
VEZT	hsa-miR-548e-3p	80.2805	NM_017599
VEZT	hsa-miR-548f-3p	80.2805	NM_017599
VEZT	hsa-miR-548az-3p	80.2805	NM_017599
VEZT	hsa-miR-548bc	80.2805	NM_017599
VEZT	hsa-miR-411-3p	80.043	NM_017599
VEZT	hsa-miR-379-3p	80.043	NM_017599

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Motifs and transcription factors (TFs) regulating VEZT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VEZT	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
VEZT	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."