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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VEZF1

Summary for VEZF1

Gene information	Gene symbol	VEZF1
	Ensembl ID	ENSG00000136451
	Entrez ID	7716
	Gene name	vascular endothelial zinc finger 1
	Synonyms	DB1\|ZNF161
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: VEZF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.44469	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.307921	1.40e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.2605	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.330435	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.635518	7.21e-42

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Expression of VEZF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VEZF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VEZF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VEZF1	hsa-miR-4666a-3p	99.0362	NM_007146
VEZF1	hsa-miR-4699-3p	99.0218	NM_007146
VEZF1	hsa-miR-133a-5p	98.8891	NM_007146
VEZF1	hsa-miR-10523-5p	98.1316	NM_007146
VEZF1	hsa-miR-3129-3p	97.7379	NM_007146
VEZF1	hsa-miR-5583-5p	97.7379	NM_007146
VEZF1	hsa-miR-4666b	97.4286	NM_007146
VEZF1	hsa-miR-4775	96.2506	NM_007146
VEZF1	hsa-miR-5700	96.166	NM_007146
VEZF1	hsa-miR-3189-3p	95.5375	NM_007146
VEZF1	hsa-miR-3680-3p	95.2186	NM_007146
VEZF1	hsa-miR-5689	94.7155	NM_007146
VEZF1	hsa-miR-548x-3p	93.9059	NM_007146
VEZF1	hsa-miR-548aj-3p	93.9059	NM_007146
VEZF1	hsa-miR-548az-5p	93.1431	NM_007146
VEZF1	hsa-miR-548t-5p	93.1431	NM_007146
VEZF1	hsa-miR-17-3p	92.7146	NM_007146
VEZF1	hsa-miR-1251-3p	92.5569	NM_007146
VEZF1	hsa-let-7a-3p	92.4062	NM_007146
VEZF1	hsa-miR-98-3p	92.4062	NM_007146
VEZF1	hsa-let-7b-3p	92.4062	NM_007146
VEZF1	hsa-let-7f-1-3p	92.4062	NM_007146
VEZF1	hsa-miR-509-3p	92.1272	NM_007146
VEZF1	hsa-miR-5681b	91.965	NM_007146
VEZF1	hsa-miR-548aq-3p	91.4793	NM_007146
VEZF1	hsa-miR-548ae-3p	91.4793	NM_007146
VEZF1	hsa-miR-448	91.2042	NM_007146
VEZF1	hsa-miR-212-5p	91.1098	NM_007146
VEZF1	hsa-miR-7114-5p	90.5963	NM_007146
VEZF1	hsa-miR-4318	90.496	NM_007146
VEZF1	hsa-miR-4297	90.0556	NM_007146
VEZF1	hsa-miR-186-3p	90.0239	NM_007146
VEZF1	hsa-miR-548ah-3p	89.7653	NM_007146
VEZF1	hsa-miR-548am-3p	89.7653	NM_007146
VEZF1	hsa-miR-548j-3p	89.7653	NM_007146
VEZF1	hsa-let-7a-2-3p	89.3533	NM_007146
VEZF1	hsa-let-7g-3p	89.3533	NM_007146
VEZF1	hsa-miR-4729	89.272	NM_007146
VEZF1	hsa-miR-5688	89.2589	NM_007146
VEZF1	hsa-miR-300	88.5729	NM_007146
VEZF1	hsa-miR-381-3p	88.5729	NM_007146
VEZF1	hsa-miR-6882-3p	88.3348	NM_007146
VEZF1	hsa-miR-4684-5p	88.0284	NM_007146
VEZF1	hsa-miR-219b-5p	88.0014	NM_007146
VEZF1	hsa-miR-495-3p	87.9294	NM_007146
VEZF1	hsa-miR-8054	87.6219	NM_007146
VEZF1	hsa-miR-548k	87.6219	NM_007146
VEZF1	hsa-miR-548av-5p	87.6219	NM_007146
VEZF1	hsa-miR-5591-3p	87.6107	NM_007146
VEZF1	hsa-miR-5011-5p	87.3076	NM_007146

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Motifs and transcription factors (TFs) regulating VEZF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VEZF1	metacluster_7.13	ZFX (directAnnotation).
VEZF1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
VEZF1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
VEZF1	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
VEZF1	metacluster_151.2	ZNF23 (directAnnotation).
VEZF1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
VEZF1	transfac_pro__M05479	ZNF580 (directAnnotation).
VEZF1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
VEZF1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
VEZF1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
VEZF1	hdpi__ETV4	ETV4 (directAnnotation).
VEZF1	transfac_pro__M06071	ZNF814 (directAnnotation).
VEZF1	transfac_pro__M05628	ZNF735 (directAnnotation).
VEZF1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
VEZF1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
VEZF1	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
VEZF1	jaspar__MA0079.5	SP1 (directAnnotation).
VEZF1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
VEZF1	transfac_pro__M04826	EP300 (directAnnotation).
VEZF1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
VEZF1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
VEZF1	transfac_pro__M07397	ZNF148 (directAnnotation).
VEZF1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
VEZF1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
VEZF1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
VEZF1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
VEZF1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
VEZF1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
VEZF1	transfac_pro__M01175	ZBTB7B (directAnnotation).
VEZF1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
VEZF1	tfdimers__MD00151	CHURC1 (directAnnotation).
VEZF1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
VEZF1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
VEZF1	transfac_pro__M01303	SP1 (directAnnotation).
VEZF1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
VEZF1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
VEZF1	transfac_pro__M02090	E2F4 (directAnnotation).
VEZF1	transfac_pro__M01714	KLF15 (directAnnotation).
VEZF1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
VEZF1	jaspar__MA1122.1	TFDP1 (directAnnotation).
VEZF1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
VEZF1	transfac_pro__M02089	E2F3 (directAnnotation).
VEZF1	metacluster_3.14	WT1; WT1 (directAnnotation).
VEZF1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
VEZF1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
VEZF1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
VEZF1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
VEZF1	cisbp__M07938	E2F1 (directAnnotation).
VEZF1	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
VEZF1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."