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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VEGFC

Summary for VEGFC

Gene information	Gene symbol	VEGFC
	Ensembl ID	ENSG00000150630
	Entrez ID	7424
	Gene name	vascular endothelial growth factor C
	Synonyms	VEGF-C\|VRP
	Gene type	protein_coding
	UniProtAcc	P49767

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Dataset with differentially expressed gene: VEGFC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.608709	0.00e+00

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Expression of VEGFC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VEGFC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
VEGFC	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating VEGFC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VEGFC	hsa-miR-587	97.1463	NM_005429
VEGFC	hsa-miR-128-3p	94.5141	NM_005429
VEGFC	hsa-miR-216a-3p	94.5141	NM_005429
VEGFC	hsa-miR-655-3p	94.0416	NM_005429
VEGFC	hsa-miR-374c-5p	94.0416	NM_005429
VEGFC	hsa-miR-3163	92.8626	NM_005429
VEGFC	hsa-miR-5093	92.0565	NM_005429
VEGFC	hsa-miR-513b-5p	91.7455	NM_005429
VEGFC	hsa-miR-3681-3p	91.604	NM_005429
VEGFC	hsa-miR-3680-3p	91.2356	NM_005429
VEGFC	hsa-miR-369-3p	90.9088	NM_005429
VEGFC	hsa-miR-548c-3p	90.6653	NM_005429
VEGFC	hsa-miR-374a-5p	87.6591	NM_005429
VEGFC	hsa-miR-122b-5p	87.089	NM_005429
VEGFC	hsa-miR-374b-5p	85.1452	NM_005429
VEGFC	hsa-miR-3688-5p	83.5009	NM_005429
VEGFC	hsa-miR-5692c	82.0195	NM_005429
VEGFC	hsa-miR-5692b	82.0195	NM_005429
VEGFC	hsa-miR-455-3p	80.1067	NM_005429

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Motifs and transcription factors (TFs) regulating VEGFC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VEGFC	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
VEGFC	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
VEGFC	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
VEGFC	transfac_pro__M04826	EP300 (directAnnotation).
VEGFC	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
VEGFC	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
VEGFC	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
VEGFC	jaspar__MA1122.1	TFDP1 (directAnnotation).
VEGFC	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."