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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: VDAC2

Summary for VDAC2

Gene information	Gene symbol	VDAC2
	Ensembl ID	ENSG00000165637
	Entrez ID	7417
	Gene name	voltage dependent anion channel 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: VDAC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.482525	4.08e-09
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.265587	6.96e-17
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.355304	1.30e-13
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.565572	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.328418	1.35e-39
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.373569	7.85e-44
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.406182	1.42e-33
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.507175	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.313349	5.82e-21
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.409852	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.292829	1.63e-24
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.969351	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.776785	0.00e+00

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Expression of VDAC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VDAC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VDAC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VDAC2	hsa-miR-212-3p	95.8054	NM_001324090
VDAC2	hsa-miR-132-3p	95.8054	NM_001324090
VDAC2	hsa-miR-664a-3p	94.7489	NM_001184823
VDAC2	hsa-miR-6758-3p	94.6501	NM_001324090
VDAC2	hsa-miR-138-2-3p	94.0975	NM_001184823
VDAC2	hsa-miR-12123	93.6791	NM_001184823
VDAC2	hsa-miR-6891-3p	93.0616	NM_001184823
VDAC2	hsa-miR-6072	93.0616	NM_001184823
VDAC2	hsa-miR-5688	92.4334	NM_001184823
VDAC2	hsa-miR-4753-5p	91.5786	NM_001184823
VDAC2	hsa-miR-12120	91.025	NM_001324090
VDAC2	hsa-miR-495-3p	90.3343	NM_001184823
VDAC2	hsa-miR-6131	86.7806	NM_001324090
VDAC2	hsa-miR-1184	86.1619	NM_001324090
VDAC2	hsa-miR-8064	85.8231	NM_001184823
VDAC2	hsa-miR-5196-3p	85.2379	NM_001184823
VDAC2	hsa-miR-708-3p	85.1047	NM_001324090
VDAC2	hsa-miR-4799-5p	85.0793	NM_001324090
VDAC2	hsa-miR-1275	83.1431	NM_001324090
VDAC2	hsa-miR-596	82.688	NM_001184823
VDAC2	hsa-miR-5093	81.9734	NM_001324090
VDAC2	hsa-miR-6893-3p	81.466	NM_001184823
VDAC2	hsa-miR-3688-3p	80.2683	NM_001324090

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Motifs and transcription factors (TFs) regulating VDAC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VDAC2	metacluster_151.2	ZNF23 (directAnnotation).
VDAC2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
VDAC2	jaspar__MA0079.5	SP1 (directAnnotation).
VDAC2	transfac_pro__M06213	ZNF267 (directAnnotation).
VDAC2	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
VDAC2	transfac_pro__M01199	TRIM28 (directAnnotation).
VDAC2	hdpi__TIMELESS	TIMELESS (directAnnotation).
VDAC2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
VDAC2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
VDAC2	transfac_pro__M04826	EP300 (directAnnotation).
VDAC2	transfac_pro__M05544	BCL11A (directAnnotation).
VDAC2	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
VDAC2	"Aluminium monostearate"	DB01375	small molecule
VDAC2	"PRLX 93936"	DB06098	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."